DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and mog-5

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_495019.1	Gene:	mog-5 / 173920	WormBaseID:	WBGene00003393	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	229/754 - (30%)
Similarity:	369/754 - (48%)	Gaps:	101/754 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SRIKKKADEHASSRRRTQINLIEFSFLDHKAELVGLL-----QAKSRQVGRSLVENEADFWKFVG 61
            :|::....|....|:.....::..:.:....|.:|:|     ::....:...|||:|.||.:..|
Worm   361 ARVRISTPERWELRQMQGAGVLTATDMPDFDEEMGVLRNYDDESDGEDIEIELVEDEPDFLRGYG 425

  Fly    62 KYEAMMRSTGQPVLPPR-----LAEAELSS--------------------------------MQP 89
            |..|.:    :||...:     ||:|.|..                                :.|
Worm   426 KGGAEI----EPVKVVKNPDGSLAQAALMQGALSKERKETKIQAQRERDMDTQKGFSSNARILDP 486

  Fly    90 YHRSKHLALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKD 154
            ...::..|...|..:.......:|....:|   |....:.|...:....:.:.:.:|||...:|:
Worm   487 MSGNQSTAWSADESKDRNNKMKEMPEWLKH---VTAGGKATYGRRTNLSMVEQRESLPIFALKKN 548

  Fly   155 LREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGY---RSIACTQPRRLACVSLCKRVAHELLDDY 216
            |.||:..:::::|.|:||.||:||:.||..:.|.   ..|.||||||:|.:|:.||||.|.....
Worm   549 LMEAMIDNQILVVVGETGSGKTTQMTQYAIEAGLGRRGKIGCTQPRRVAAMSVAKRVAEEYGCKL 613

  Fly   217 GSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKC 281
            |:.|.:.||||...::.|.|.::|:|:|||:..:..:|..|..::|||.|||.:..|.|.|:.|.
Worm   614 GTDVGYTIRFEDCTSQDTIIKYMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHTDVLFGLLKA 678

  Fly   282 LLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALE-LKAGQATSKR 345
            ..|.||:||||:.|||::...|..||.|  |.:..:|||.||:::.|...|..: |:|...|
Worm   679 AARKRPELKLIITSATLDSVKFSEYFLE--APIFTIPGRTFPVEILYTREPESDYLEAAHIT--- 738

  Fly   346 SQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE----YATEQTHWLVLP 406
                             :.|.:.|...||||:|::|..||::..|.::|    ...:....::||
Worm   739 -----------------VMQIHLTEPPGDVLVFLTGQEEIDTSCEVLYERMKSMGPDVPELIILP 786

  Fly   407 LHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKE 471
            ::.......|:::||.||.|.||.:::|||||||||:||:.:|||.|.||:..::.......|..
Worm   787 VYGALPSEMQTRIFDPAPAGKRKVVIATNIAETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVV 851

  Fly   472 FWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPT--PEIYRVPLDTMLLQMVSMGLPDV 534
            ..:|:::|.||.|||||||||.|:||||...:.. |..||  |||.|..|.:.|||:.:||:.::
Worm   852 TPISQAAAKQRSGRAGRTGPGKCYRLYTERAFRD-EMLPTPVPEIQRTNLASTLLQLKAMGINNL 915

  Fly   535 RAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQL 599
            ..|.|::||..:.:...:..|....||..:..:|.|||.:|..|:|.|:.|:|:|.......|::
Worm   916 IDFDFMDAPPLDSMITALNTLHTLSALDGDGLLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEV 980

  Fly   600 LTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGTRQWC 660
            ||:.|||:|||    |...:.|.||:    :.......||..||:.:||.|    .....::.||
Worm   981 LTIVAMLNVQNIFYRPKEKQDHADQK----KAKFHQPEGDHLTLLAVYNSW----KNHHFSQPWC 1037

  Fly   661 RRLGIEEQRFYEVTKLRQQFQRILE-------SCGMVVA 692
            ....|:.:.......:|:|...|::       |||..|:
Worm  1038 FENFIQVRSMKRAQDIRKQLLGIMDRHKLLMVSCGRDVS 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	73/174 (42%)
		DEXDc	163..298	CDD:238005	59/137 (43%)
		Helicase_C	358..490	CDD:278689	49/135 (36%)
		HA2	560..640	CDD:214852	29/83 (35%)
		OB_NTP_bind	<792..897	CDD:285018
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189
		DEXDc	534..721	CDD:214692	77/188 (41%)
		DEXDc	557..695	CDD:238005	59/137 (43%)
		HELICc	766..870	CDD:197757	39/103 (38%)
		HA2	939..1021	CDD:214852	29/85 (34%)
		OB_NTP_bind	1055..1154	CDD:285018	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810