DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and let-355

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_491604.3	Gene:	let-355 / 172199	WormBaseID:	WBGene00020263	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	769	Identity:	228/769 - (29%)
Similarity:	346/769 - (44%)	Gaps:	146/769 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRIKKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEA---------DF 56
            :|:|.:....:.:| |:|.....:|..|:...:...||:.|.:|:.....|.|.         ..
Worm    34 ISKILQNGKVNGNS-RQTGGQEQKFQNLEALKKKTMLLKKKKKQMNNFQKEEELLSSTFRITNGI 97

  Fly    57 WKFVGKYEAMMRSTGQPVLPPRLAEAELSSMQ---PYHRSKHLALRLDADELLQEARDQMQSQFR 118
            .|...|.|....||..|...|:...:..|:.:   |....||.:        .|::....::.:
Worm    98 LKKEKKIEVTTISTQTPKKLPKTPISTPSNSKNATPMSTRKHSS--------SQQSPPHFEANY- 153

  Fly   119 HILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYL 183
                        |||.|        ..|||....:.|...|.:...:||.|:||.||||||||..
Worm   154 ------------EKFSR--------PQLPIDAVEQQLMYELASQETLIVIGETGSGKSTQVPQLC 198

  Fly   184 YDFGYR---SIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLL 245
            ...|..   |||.|||||:|.:||..|||.|:..:.|..|.:.:|||.:....|.|.::|:|::|
Worm   199 VRAGIANSGSIAVTQPRRVAAISLASRVATEMGTNIGGIVGYHVRFENATCHKTKIEYMTDGIVL 263

  Fly   246 RQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLR--------ARPQLKLILMSATINVEL 302
            |:..|:..||:|..:|:||.|||:|..|.|:    |:||        ....|:||:||||:..|.
Worm   264 RKALVSPLLDKYSCVIIDEAHERSLHSDVLM----CILRQCQDQRRETNNPLRLIIMSATLQAEK 324

  Fly   303 FHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQ-RNRIDPAPFVQVLSLIDQQ 366
            |..||  ..|::|.|.||.|||::.::.|     |..::.|.... .|.:....:|.:
Worm   325 FQSYF--NNAKVVLVAGRTFPIEVFHVNP-----KINKSFSSTDYVYNAVICVKYVHL------- 375

  Fly   367 YPTSERG-DVLIFVSGVNEIESVVEAVHE----YATEQTHWLVLPLHSGQAIADQSKVFDYAPEG 426
              |..:| |:|:|::|..|||:|...:.|    ........:.:||::......|.:.|...|:|
Worm   376 --TEPKGRDILVFLTGSEEIEAVASQLAELNGSLPASADVLMPVPLYAALRPEKQKEAFRKTPQG 438

  Fly   427 MRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGP 491
            .||.|:||||||||:|:.|:|.|:||||||...|:|..:...||...|||:.|.||.|||||..|
Worm   439 ARKVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNVSKAQAKQRAGRAGRDAP 503

  Fly   492 GVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALK 556
            |.|:|||:.|.::.|||...|||.|..|....|:::.:|:.:......|:.|||:.|...:|
Worm   504 GKCYRLYSREDFHKFEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPETDNINAALL--- 565

  Fly   557 QHCALSVEEKITPLGRSLANLPVELSIGKMLL--MGSVF------PE--------------VEQL 599
                     ::|.||   |..||.....|..|  ||..|      |:              :|.:
Worm   566 ---------ELTSLG---AIRPVNSDRSKFALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAI 618

  Fly   600 LTLAAMLS---VQNPLTNRAHTDQRCVRER-ESLESDHGDLFTLVRLYNVWV-QLKMRRDG---- 655
            ..:|||.:   ......:::..|...:|.| |:.|.||..|..||.:.|.:. ||..:.:.
Worm   619 KIVAAMQTDALFSGAGDSKSDADVDRIRRRFETREGDHITLLKLVLVTNQFFDQLNKKTESDARY 683

  Fly   656 --------------TRQWCRRLGIEEQRFYEVTKLRQQFQRI-------LESCG 688
                          .|::|....|.||.....:.:.:|.::|       ..:||
Worm   684 GKANKSLEREYNQTIRKFCNDNMINEQHLKTASMIEEQLKQIAIEQKVTFSTCG 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	77/182 (42%)
		DEXDc	163..298	CDD:238005	62/145 (43%)
		Helicase_C	358..490	CDD:278689	53/136 (39%)
		HA2	560..640	CDD:214852	24/105 (23%)
		OB_NTP_bind	<792..897	CDD:285018
let-355	NP_491604.3	HrpA	149..>800	CDD:224557	203/645 (31%)
		DEXDc	180..320	CDD:238005	62/143 (43%)
		Helicase_C	383..500	CDD:278689	48/116 (41%)
		HA2	569..660	CDD:214852	22/93 (24%)
		OB_NTP_bind	712..822	CDD:285018	4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820