DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32533 and DHX36

DIOPT Version :9

Sequence 1:NP_001285437.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster
Sequence 2:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens


Alignment Length:1051 Identity:282/1051 - (26%)
Similarity:446/1051 - (42%) Gaps:246/1051 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKKADEHASSRRRTQINLIEFSFLDHKAELVGLLQAKSRQVGRSLVENEADFWKFVGK---YEAM 66
            :::|..|...||..||           .:|:..:|||:.:      |:||....|..:   |...
Human    80 QERAVVHMDERREEQI-----------VQLLNSVQAKNDK------ESEAQISWFAPEDHGYGTE 127

  Fly    67 MRSTGQP-------VLPPRLAEAELSSMQPYHRSKHLALRLDADELLQEARDQMQSQFRHILLVY 124
            :.:...|       :...:|...|....:..:||   .:..|::.||||  ::........||. 
Human   128 VSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRS---YIDRDSEYLLQE--NEPDGTLDQKLLE- 186

  Fly   125 LDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYD---- 185
             |.::.:...|..:::..:..||....:|:|...:|..:|.:::|:|||||:|||.|::.|    
Human   187 -DLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIE 250

  Fly   186 FGYRS---IACTQPRRLACVSLCKRVAHELLDDYGS--RVAFQIRFE-RSRTKLTNILFITEGLL 244
            .|..|   |.||||||::.:|:.:|||.|..:..||  ...:|||.: |...|..:||:.|.|::
Human   251 RGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGII 315

  Fly   245 LRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGE 309
            |:.|.....|.....::|||||||||..|.|:.|.|.||..|..||:||||||:|.|.|..||| 
Human   316 LQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFG- 379

  Fly   310 EGARLVQVPGRLFPI----------KLRYLPPPALELKAGQATSKRS------------------ 346
             ...::.:||..||:          |:||:|    |.|..::..||.                  
Human   380 -NCPMIHIPGFTFPVVEYLLEDVIEKIRYVP----EQKEHRSQFKRGFMQGHVNRQEKEEKEAIY 439

  Fly   347 ---------QRNRIDPAPFVQVLSLIDQ------------QYPT--SERGDVLIFVSGVNEIESV 388
                     :..|...|..|.|:.:::.            :|..  .|.|.:|:|:.|.:.|.: 
Human   440 KERWPDYVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNIST- 503

  Fly   389 VEAVHEYATEQT-----HWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRF 448
               :|:....|.     .:|::||||.....:|::||...|.|:||.:::|||||||:|:|.|.:
Human   504 ---LHDLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVY 565

  Fly   449 VVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPE 513
            |:|.||:||.:||.......:...||||::|.||||||||..||.|:.||...:.:..:.|..||
Human   566 VIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPE 630

  Fly   514 IYRVPLDTMLLQMVSMGLPDVRAF--PFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLAN 576
            |.|.||:.:.||:..:.|..:..|  ..::.|..|.:..:|..|.:..||..:|::||||..||.
Human   631 ILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLAR 695

  Fly   577 LPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESLESD-HGDLFTLV 640
            ||||..||||:|.|::|..::.:||:||.||.::|.......::.....|:.|..| ..|..|:|
Human   696 LPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVV 760

  Fly   641 RLYNVWVQLKMRRDGTR---QWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVA---SDSDSQL 699
            ..:..|.:  .||.|.|   .:|....:.......:..::.||...|...|.|.:   .|.:|.:
Human   761 NAFEGWEE--ARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNI 823

  Fly   700 TSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQGDDMRDVDFRLRFD 764
            .|                                        |.|:                   
Human   824 NS----------------------------------------DNEK------------------- 829

  Fly   765 PRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPNS 829
                                ::|.::.:|.||::| ....|..|.......:|:....|..||.|
Human   830 --------------------IIKAVICAGLYPKVA-KIRLNLGKKRKMVKVYTKTDGLVAVHPKS 873

  Fly   830 QFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQTLLLF- 893
                    :.:.::|.               .:..|.|...:.|:..||.:|..: :...||.| 
Human   874 --------VNVEQTDF---------------HYNWLIYHLKMRTSSIYLYDCTEV-SPYCLLFFG 914

  Fly   894 -SFAIDTNAGITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQESPSHS 957
             ..:|..:.....||.|.|:....|     ..:.....|||:....||.:|:       ||| |.
Human   915 GDISIQKDNDQETIAVDEWIVFQSP-----ARIAHLVKELRKELDILLQEKI-------ESP-HP 966

  Fly   958 SDDRSSALWQD 968
            .|      |.|
Human   967 VD------WND 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32533NP_001285437.1 DEXDc 155..327 CDD:214692 77/191 (40%)
DEXDc 163..298 CDD:238005 63/144 (44%)
Helicase_C 358..490 CDD:278689 53/150 (35%)
HA2 560..640 CDD:214852 32/80 (40%)
OB_NTP_bind <792..897 CDD:285018 21/106 (20%)
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 29/143 (20%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 8/35 (23%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 94/294 (32%)
DEXDc 210..392 CDD:214692 75/183 (41%)
DEXDc 224..369 CDD:238005 63/144 (44%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 18/51 (35%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 74/248 (30%)
Helicase_C 476..606 CDD:278689 51/133 (38%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 20/62 (32%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 5/10 (50%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 24/68 (35%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 17/58 (29%)
HA2 676..760 CDD:214852 32/83 (39%)
OB_NTP_bind 800..917 CDD:285018 32/220 (15%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 16/87 (18%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 8/52 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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