DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32533 and DHX9

DIOPT Version :10

Sequence 1:NP_728244.1 Gene:CG32533 / 32933 FlyBaseID:FBgn0052533 Length:1139 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:776 Identity:221/776 - (28%)
Similarity:361/776 - (46%) Gaps:130/776 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ADEHASS-------------RRRTQINLIE-FSFLDHKAE-------LVGLLQAKSRQVGRSLVE 51
            |.||.|:             |:...:.::| :|.|..|.|       .|.|.|....|:...:.|
Human   228 AREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQE 292

  Fly    52 NEADFWKFVGKYEAMMRSTGQPVLPPRLAEAELSSMQPYHRSKHLAL----------------RL 100
            ...:          ::.....|.:|..|...:|:..:|..|...:.:                .:
Human   293 LNLE----------ILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNI 347

  Fly   101 DADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVV 165
            |...|.....:|:....::.|:.     |.|:...::.:.|.:..||:.:|..::.||:..:.||
Human   348 DEGPLAFATPEQISMDLKNELMY-----QLEQDHDLQAILQERELLPVKKFESEILEAISQNSVV 407

  Fly   166 IVAGDTGCGKSTQVPQYLYDFGYR-------SIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQ 223
            |:.|.|||||:|||||::.|...:       :|..|||||::.||:.:|||.|..::.|....:.
Human   408 IIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYS 472

  Fly   224 IRFERSRTK-LTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARP 287
            :|||....: ..:|:|.|.|:|||:|  .|.:.....:|:||||||::..||||.|.:.:::|.|
Human   473 VRFESILPRPHASIMFCTVGVLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYP 535

  Fly   288 QLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIK----------LRYLPPPALELKA---- 338
            :::::||||||:..:|..||  ....:::|.||.:|::          ..::|||..:.|.    
Human   536 EVRIVLMSATIDTSMFCEYF--FNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDD 598

  Fly   339 ------------------GQATS-KRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNE 384
                              |..|. ..||.|..: .||..:.:|:......:..|.||:|:.|.|.
Human   599 DGGEDDDANCNLICGDEYGPETRLSMSQLNEKE-TPFELIEALLKYIETLNVPGAVLVFLPGWNL 662

  Fly   385 IESVVEAV--------HEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSL 441
            |.::.:.:        |.|.       :|||||.....:|.||||..|.|:.|.|:||||||||:
Human   663 IYTMQKHLEMNPHFGSHRYQ-------ILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSI 720

  Fly   442 TVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAF 506
            |::.|.:|:||.|.|...|.|..........|.||::.:||||||||..||.||.|.:..::...
Human   721 TINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERL 785

  Fly   507 EAYPTPEIYRVPLDTMLLQMVSMGLPDVRAF--PFIEAPETERIEQTILALKQHCALSVEEKITP 569
            |.:.|||::|.||..:.|.:..:.|..:..|  ..||.|..:.:.:....|::..||...:::||
Human   786 ETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTP 850

  Fly   570 LGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNR----AHTDQRCVRERESLE 630
            |||.||.||:|...|||::||.:|...:.:.|:||......|..|.    .:..:.....|   .
Human   851 LGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNR---F 912

  Fly   631 SDHGDLFTLVRLYNVWVQLKM-RRDGTRQWC--RRLGIEEQRFYEVTKLRQQFQRILESCG 688
            |||   ..|:.::..|...:| ..:...::|  :||.:...|.....|:  |.:.||.:.|
Human   913 SDH---VALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKV--QLKEILINSG 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32533NP_728244.1 HrpA 145..>619 CDD:441249 177/528 (34%)
OB_NTP_bind 792..897 CDD:400182
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250 5/21 (24%)
DSRM_DHX9_rpt1 3..71 CDD:380683
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118
DSRM_DHX9_rpt2 178..252 CDD:380684 5/23 (22%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325 20/104 (19%)
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236 0/1 (0%)
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 113/428 (26%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 197/661 (30%)
DEXHc_DHX9 330..563 CDD:350730 75/241 (31%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 6/53 (11%)
HrpA 388..>886 CDD:441249 174/509 (34%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 145/422 (34%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 4/8 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 2/19 (11%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 28/93 (30%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 4/13 (31%)
OB_NTP_bind 994..1073 CDD:400182
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248
Blue background indicates that the domain is not in the aligned region.

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