Protein Alignment CG32533 and DHX8

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: NP_004932.1
• Gene: DHX8 / 1659
• HGNCID: 2749
• Length: 1220
• Species: Homo sapiens
• Alignment Length: 871
• Identity: 258/871 - (29%)
• Similarity: 408/871 - (46%)
• Gaps: 155/871 - (17%)

  Fly     9 DEHASSRRRTQI--------------NLI---EFSFLDHKAELVGLL----QAKSRQVGRSLVEN 52
            |:....:|.|:|              |::   ||...|   |..|:|    ..:...:...|||.
Human   383 DDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD---EETGILPKVDDEEDEDLEIELVEE 444

  Fly    53 EADFWKFVGKYE-------------------AMMRST---GQPVLPPRLAEAELSSMQPYHRSKH 95
            |..|.:...|..                   |||:|.   .:..|.....|||:.|: |...:||
Human   445 EPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSI-PMGLNKH 508

  Fly    96 LALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKF-----------QRIRKLRQTQRNLPIA 149
            .     .|.|......|:.:..|.|.::..|..:.:|.           :....:.:.:.:|||.
Human   509 W-----VDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIY 568

  Fly   150 RFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHE 211
            :.::.|.:|:..::::||.|:||.||:||:.|||.:.||.|   |.||||||:|.:|:.|||:.|
Human   569 KLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEE 633

  Fly   212 LLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLL 276
            .....|..|.:.||||...:..|.|.::|:|:|||:..:..:|.||..::|||.|||.:..|.|.
Human   634 FGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLF 698

  Fly   277 GVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQA 341
            |:.|..::.|..:|||:.|||::...|..||.|  |.:..:|||.:|:::.|
Human   699 GLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYE--APIFTIPGRTYPVEILY------------- 748

  Fly   342 TSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE----YATEQTHW 402
             :|..:.:.:| |..:.|:    |.:.|...||:|:|::|..||::..|.::|    ...:....
Human   749 -TKEPETDYLD-ASLITVM----QIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPEL 807

  Fly   403 LVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQ 467
            ::||::|......|:::||.||.|.||.:::|||||||||:||:.:|||.|.||:..:::.....
Human   808 IILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGID 872

  Fly   468 RLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPT--PEIYRVPLDTMLLQMVSMG 530
            :|....:|::.|.||.|||||||||.|:||||...|.. |...|  |||.|..|.:.:|.:.:||
Human   873 QLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRD-EMLTTNVPEIQRTNLASTVLSLKAMG 936

  Fly   531 LPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPE 595
            :.|:.:|.|::||..|.:...:..|....||..|..:|.|||.:|..|:|..:.|||:|......
Human   937 INDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGC 1001

  Fly   596 VEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGT 656
            .|::||:.:||||||    |...:|..||:    :.......||..||:.:||.|...|.    :
Human  1002 SEEMLTIVSMLSVQNVFYRPKDKQALADQK----KAKFHQTEGDHLTLLAVYNSWKNNKF----S 1058

  Fly   657 RQWCRRLGIEEQRFYEVTKLRQQFQRILE-------SCGMVVASDSDSQLTSAERATRHGELRQL 714
            ..||....|:.:.......:|:|...|::       |||        ......::|...|..|
Human  1059 NPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCG--------KSTVRVQKAICSGFFR-- 1113

  Fly   715 KAMKRRQRFEQPRQ--RKLLKQSA--------------------GRVAEDEEEQEEAQGDDMR-D 756
            .|.|:     .|::  |.|:.|..                    ..|...:|...|....|.| .
Human  1114 NAAKK-----DPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWL 1173

  Fly   757 VDFRLRF----DPRQLALLERSSRLD 778
            |:|...|    ||.:|:..::..||:
Human  1174 VEFAPAFFKVSDPTKLSKQKKQQRLE 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	181/486 (37%)
		OB_NTP_bind	792..897	CDD:400182
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..266
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..372
		HrpA	556..>1187	CDD:441249	218/675 (32%)
		DEAH box	685..688		2/2 (100%)