DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and DHX8

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens

Alignment Length:	871	Identity:	258/871 - (29%)
Similarity:	408/871 - (46%)	Gaps:	155/871 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DEHASSRRRTQI--------------NLI---EFSFLDHKAELVGLL----QAKSRQVGRSLVEN 52
            |:....:|.|:|              |::   ||...|   |..|:|    ..:...:...|||.
Human   383 DDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD---EETGILPKVDDEEDEDLEIELVEE 444

  Fly    53 EADFWKFVGKYE-------------------AMMRST---GQPVLPPRLAEAELSSMQPYHRSKH 95
            |..|.:...|..                   |||:|.   .:..|.....|||:.|: |...:||
Human   445 EPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSI-PMGLNKH 508

  Fly    96 LALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKF-----------QRIRKLRQTQRNLPIA 149
            .     .|.|......|:.:..|.|.::..|..:.:|.           :....:.:.:.:|||.
Human   509 W-----VDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIY 568

  Fly   150 RFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS---IACTQPRRLACVSLCKRVAHE 211
            :.::.|.:|:..::::||.|:||.||:||:.|||.:.||.|   |.||||||:|.:|:.|||:.|
Human   569 KLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEE 633

  Fly   212 LLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLL 276
            .....|..|.:.||||...:..|.|.::|:|:|||:..:..:|.||..::|||.|||.:..|.|.
Human   634 FGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLF 698

  Fly   277 GVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQA 341
            |:.|..::.|..:|||:.|||::...|..||.|  |.:..:|||.:|:::.|
Human   699 GLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYE--APIFTIPGRTYPVEILY------------- 748

  Fly   342 TSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE----YATEQTHW 402
             :|..:.:.:| |..:.|:    |.:.|...||:|:|::|..||::..|.::|    ...:....
Human   749 -TKEPETDYLD-ASLITVM----QIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPEL 807

  Fly   403 LVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQ 467
            ::||::|......|:::||.||.|.||.:::|||||||||:||:.:|||.|.||:..:::.....
Human   808 IILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGID 872

  Fly   468 RLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPT--PEIYRVPLDTMLLQMVSMG 530
            :|....:|::.|.||.|||||||||.|:||||...|.. |...|  |||.|..|.:.:|.:.:||
Human   873 QLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRD-EMLTTNVPEIQRTNLASTVLSLKAMG 936

  Fly   531 LPDVRAFPFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPE 595
            :.|:.:|.|::||..|.:...:..|....||..|..:|.|||.:|..|:|..:.|||:|......
Human   937 INDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGC 1001

  Fly   596 VEQLLTLAAMLSVQN----PLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGT 656
            .|::||:.:||||||    |...:|..||:    :.......||..||:.:||.|...|.    :
Human  1002 SEEMLTIVSMLSVQNVFYRPKDKQALADQK----KAKFHQTEGDHLTLLAVYNSWKNNKF----S 1058

  Fly   657 RQWCRRLGIEEQRFYEVTKLRQQFQRILE-------SCGMVVASDSDSQLTSAERATRHGELRQL 714
            ..||....|:.:.......:|:|...|::       |||        ......::|...|..|
Human  1059 NPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCG--------KSTVRVQKAICSGFFR-- 1113

  Fly   715 KAMKRRQRFEQPRQ--RKLLKQSA--------------------GRVAEDEEEQEEAQGDDMR-D 756
            .|.|:     .|::  |.|:.|..                    ..|...:|...|....|.| .
Human  1114 NAAKK-----DPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWL 1173

  Fly   757 VDFRLRF----DPRQLALLERSSRLD 778
            |:|...|    ||.:|:..::..||:
Human  1174 VEFAPAFFKVSDPTKLSKQKKQQRLE 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	72/174 (41%)
		DEXDc	163..298	CDD:238005	60/137 (44%)
		Helicase_C	358..490	CDD:278689	50/135 (37%)
		HA2	560..640	CDD:214852	30/83 (36%)
		OB_NTP_bind	<792..897	CDD:285018
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266
		RpsA	<263..422	CDD:223613	8/41 (20%)
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372
		HrpA	557..1219	CDD:224557	222/688 (32%)
		DEAH box	685..688		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810