DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and DQX1

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_598376.2	Gene:	DQX1 / 165545	HGNCID:	20410	Length:	717	Species:	Homo sapiens

Alignment Length:	783	Identity:	195/783 - (24%)
Similarity:	310/783 - (39%)	Gaps:	173/783 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 TEKFQRIRKLRQTQRNLPIARFRKDLREALDT--SRVVIVAGDTGCGKSTQVPQYLYDF----GY 188
            :.::..:.|.||.   |||...|....|.|::  :.||:|:|:.|.|||||:||:..:|    |:
Human    32 SSRYYELLKQRQA---LPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGF 93

  Fly   189 R--SIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVA 251
            :  .:..|||..||..||..|||.|:....|..|.:.|..|......|.:.|..:.|||:::|..
Human    94 QKGQVTVTQPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDRLLLQEVAST 158

  Fly   252 ANLDQYDALILDEIHERNLFGDFLLGVTK-CLLRARP-QLKLILMSATINVELFHGYFGEEGARL 314
            .....:..|:|||..||::..|.|.|:.: ..|...| .|::::::..........::|  ...:
Human   159 RGTGAWGVLVLDEAQERSVASDSLQGLLQDARLEKLPGDLRVVVVTDPALEPKLRAFWG--NPPI 221

  Fly   315 VQVP----GRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDV 375
            |.:|    .|..||....:||..:| .|.||                 ||.|..::.|    |||
Human   222 VHIPREPGERPSPIYWDTIPPDRVE-AACQA-----------------VLELCRKELP----GDV 264

  Fly   376 LIFVSGVNEI----ESVVEAVHEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNI 436
            |:|:....||    ||:...|.....:.....|||||.....|.|:.   |.....||.:|:..:
Human   265 LVFLPSEEEISLCCESLSREVESLLLQGLPPRVLPLHPDCGRAVQAV---YEDMDARKVVVTHWL 326

  Fly   437 AETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWV----SKSSADQRKGRAGRTGPGVCFRL 497
            |:.|.::..::.|:|||......::...:.    ||.|    ||..|:.|:.||....||.|..|
Human   327 ADFSFSLPSIQHVIDSGLELRSVYNPRIRA----EFQVLRPISKCQAEARRLRARGFPPGSCLCL 387

  Fly   498 YTAEQYNAFEA--YPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCA 560
            | .:.:...||  .|.|.:....|.:::|.:....:.:.....|::.|..|.:.|.:..|....|
Human   388 Y-PKSFLELEAPPLPQPRVCEENLSSLVLLLKRRQIAEPGECHFLDQPAPEALMQALEDLDYLAA 451

  Fly   561 LSVEEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRE 625
            |..:..::.||..|:..|:...:.|.||....|..|:::|||||||:.....|....:.:....
Human   452 LDDDGDLSDLGVILSEFPLAPELAKALLASCEFDCVDEMLTLAAMLTAAPGFTRPPLSAEEAAL- 515

  Fly   626 RESLESDHGDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMV 690
            |.:||...||..:|:::|..::|    ......||:..|:......:..|||
Human   516 RRALEHTDGDHSSLIQVYEAFIQ----SGADEAWCQARGLNWAALCQAHKLR------------- 563

  Fly   691 VASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQP----------RQRKLLKQSAG----RVAE 741
                              |||.:|     .||.|.|          .:|.|.|....    :||
Human   564 ------------------GELLEL-----MQRIELPLSLPAFGSEQNRRDLQKALVSGYFLKVA- 604

  Fly   742 DEEEQEEAQGDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLA---ISDE 803
                         ||.|                                |:|.|..|.   ::..
Human   605 -------------RDTD--------------------------------GTGNYLLLTHKHVAQL 624

  Fly   804 FNYCKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPK------PDFYTPKLPLSKRH 862
            .:||....:: ...|..|:||.| |...:|. ..|.:. |::.|:      |.::...||.|:..
Human   625 SSYCCYRSRR-APARPPPWVLYH-NFTISKD-NCLSIV-SEIQPQMLVELAPPYFLSNLPPSESR 685

  Fly   863 QLL 865
            .||
Human   686 DLL 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	55/185 (30%)
		DEXDc	163..298	CDD:238005	47/142 (33%)
		Helicase_C	358..490	CDD:278689	40/139 (29%)
		HA2	560..640	CDD:214852	24/79 (30%)
		OB_NTP_bind	<792..897	CDD:285018	21/83 (25%)
DQX1	NP_598376.2	Motor_domain	8..>89	CDD:277568	22/59 (37%)
		DEXDc	41..231	CDD:214692	58/194 (30%)
		DEXDc	65..204	CDD:238005	47/138 (34%)
		DEAQ box	170..173		2/2 (100%)
		HA2	<465..530	CDD:214852	20/65 (31%)
		OB_NTP_bind	565..674	CDD:285018	32/163 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810