DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32533 and Dhx15

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	NP_031865.2	Gene:	Dhx15 / 13204	MGIID:	1099786	Length:	795	Species:	Mus musculus

Alignment Length:	708	Identity:	210/708 - (29%)
Similarity:	346/708 - (48%)	Gaps:	69/708 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AMMRSTGQPVLPPRLAEAELSSMQPYH--RSKHLALRLDADELLQEARDQMQSQFRHILLVYLDF 127
            ||:.|.|   |||..|.....|....|  .|.|.|...........:..|..:.|.::
Mouse    67 AMLISAG---LPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHTGHTSLPQCINPFTNL------- 121

  Fly   128 RQTEKFQRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDF------ 186
            ..|.::..|.|.|   ..||:..::....:.|...:..::.|:||.||:||:||:..::
Mouse   122 PHTPRYYDILKKR---LQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPG 183

  Fly   187 GYRSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVA 251
            ..|.:|||||||:|.:|:.:|||.|:....|..|.:.||||...:..|.:.::|:|:|||:....
Mouse   184 PKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMND 248

  Fly   252 ANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQ 316
            ..|::|..:||||.|||.|..|.|:||.|.::|.|..||:|:||||::...|..||  :...|:.
Mouse   249 PLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYF--DNCPLLT 311

  Fly   317 VPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVSG 381
            :|||..|:::.|.|.|              :|:.::.|    :.::|.......|.||:|:|::|
Mouse   312 IPGRTHPVEIFYTPEP--------------ERDYLEAA----IRTVIQIHMCEEEEGDLLLFLTG 358

  Fly   382 VNEIES----VVEAVHEYATEQTHWLVLPLHSGQAIADQSKVFDYAPEGM------RKCIVSTNI 436
            ..||:.    :...|.:...|.....::||:|......|.::|:..|...      ||.:|||||
Mouse   359 QEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNI 423

  Fly   437 AETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAE 501
            ||||||:|||.||:|.|..|:..::...:.:.|....:||:||.||.||||||.||.||||||.:
Mouse   424 AETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEK 488

  Fly   502 QYNA-FEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEE 565
            .|.. .:....|||.|..|.:::||:..:|:.|:..|.|::.|..|.:.:.:..|....||:.:.
Mouse   489 AYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDG 553

  Fly   566 KITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCVRERESLE 630
            .:|.||..:|..|::..:.||::....:....::|::.|||||  |......|:.:...:...:.
Mouse   554 DLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSV--PQCFVRPTEAKKAADEAKMR 616

  Fly   631 SDH--GDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVAS 693
            ..|  ||..||:.:|:.:.|    ...:.|||....|..:.......:|||..||::...:...|
Mouse   617 FAHIDGDHLTLLNVYHAFKQ----NHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRS 677

  Fly   694 DSDSQLTSAE------RATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEE 745
               :..||.:      :|...|...|:..::|...:...:..::::.....|.:.:.|
Mouse   678 ---TDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPE 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	68/177 (38%)
		DEXDc	163..298	CDD:238005	58/140 (41%)
		Helicase_C	358..490	CDD:278689	50/141 (35%)
		HA2	560..640	CDD:214852	21/81 (26%)
		OB_NTP_bind	<792..897	CDD:285018
Dhx15	NP_031865.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		13/46 (28%)
		HrpA	124..763	CDD:224557	195/641 (30%)
		DEAH box	260..263		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810