Protein Alignment CG32533 and mle

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: XP_316626.5
• Gene: mle / 1277182
• VectorBaseID: AGAMI1_002111
• Length: 1320
• Species: Anopheles gambiae
• Alignment Length: 746
• Identity: 206/746 - (27%)
• Similarity: 349/746 - (46%)
• Gaps: 170/746 - (22%)

  Fly    79 LAEAELSSMQPYHRSKHLALRLDADELLQEARDQMQSQFRHILLVYLDFRQTEKFQRIRKLRQTQ 143
            ||.|.|..:              :::||.|:..:::...                 .::|..:|:
Mosquito   349 LATASLDQL--------------SEDLLNESSSRLKDDL-----------------ELQKSMRTR 382

  Fly   144 RNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQY-LYDF------GYRSIACTQPRRLAC 201
            ..|||:..||.:.||::...||::.|:|||||:||:.|: |.|:      .|.::..|||||::.
Mosquito   383 EKLPISAMRKPIMEAINEHPVVLIRGNTGCGKTTQIAQFILEDYINSGQGAYCNVCVTQPRRISA 447

  Fly   202 VSLCKRVAHELLDDYGSRVAFQIRFERSRTK-LTNILFITEGLLLRQLAVAANLDQYDALILDEI 265
            :|:.:|:|:|..::.|..|.:.:||:....: ..:|||.|.|:|||:|  ...|.....:|:|||
Mosquito   448 ISVSERIANERCENLGVTVGYSVRFDSVLPRPYGSILFCTIGVLLRKL--EGGLRGVSHVIVDEI 510

  Fly   266 HERNLFGDFLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLFPIK----- 325
            |||::..||:|.|.:.::...|.|::|||||||:..||..|||:  ..:::||||.||::
Mosquito   511 HERDVNSDFILVVLRDMVHTYPDLRVILMSATIDTSLFSRYFGD--CPVLEVPGRAFPVEQLFLE 573

  Fly   326 -----LRYLPPPALELKAGQATSKRSQRNRID--------------------------------- 352
                 |::.|.|.   :.|....||.:....|
Mosquito   574 DCIELLKFRPSPP---EGGAGRRKRGKDGEDDGGDGGGECDADMPECGNLNEVIDESKYSPQTKQ 635

  Fly   353 --------PAPFVQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHEYATEQTHWLVLPLHS 409
                    ..||..:.:|:|........|.||:|::|.|.|.:::..:.    .:.:.:||||||
Mosquito   636 AMAMMIEADTPFELITALVDYVDQQGRPGAVLVFLAGWNMIFALMRQLQ----PRQNLVVLPLHS 696

  Fly   410 GQAIADQSKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEF-- 472
            .....||.|||::..: .||.|::|||||||:|:|.|.:|:|           |||. |:|.|
Mosquito   697 QLPREDQRKVFNHYGQ-RRKVILATNIAETSITIDDVVYVID-----------TCKA-RMKLFTS 748

  Fly   473 ----------WVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMV 527
                      |.::::.:||||||||..||:||.|.:..::...|...|||::|.||..:.|.:.
Mosquito   749 HNNMTNYATVWAARTNLEQRKGRAGRVSPGMCFTLCSRARFAKLEENLTPEMFRTPLHELALSIK 813

  Fly   528 SMGLPDVRAF--PFIEAPETERIEQTILALKQHCALSVEEKITPLGRSLANLPVELSIGKMLLMG 590
            .:.|..:..|  ..||.|..:.:.:..:.||:...|..||::||.||.||.||:|..:|||:::.
Mosquito   814 LLRLGAIGKFLSKAIEPPPLDAVIEAEVLLKEMRCLDEEEQLTPFGRILARLPIEPRLGKMMVLS 878

  Fly   591 SVFPEVEQLLTLAA---------MLSV-QNPLTN--RAHTDQRCVRERESLESDHGDLFTLVRLY 643
            ::|...:.|.|:||         :|.: |..|.|  :|.:.|.|           .|...::..:
Mosquito   879 TLFGLCDTLTTMAAYSGTFSEVFLLELGQRRLMNHQKALSGQTC-----------SDYVAMLTAF 932

  Fly   644 NVWVQLK-MRRDGTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCG------MVVASDSDSQLTS 701
            .:|.:.: :..:...::|...|::......:.:.::|....|...|      |.:..||::..:.
Mosquito   933 EMWSKKRAIGEEAEMRFCDWKGLQMPTLRSIAEAKKQLIENLCLAGFPQDTMMPLRFDSENPDSD 997

  Fly   702 AERATR------------HGELRQLKAMKRR 720
            .|.|..            |.|.|::...:.|
Mosquito   998 LEMAMALLCIGLYPNVCYHKEKRRVLTTESR 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	179/558 (32%)
		OB_NTP_bind	792..897	CDD:400182
mle	XP_316626.5	None