Protein Alignment CG32533 and spn-E

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: XP_312084.5
• Gene: spn-E / 1273132
• VectorBaseID: AGAMI1_012317
• Length: 1463
• Species: Anopheles gambiae
• Alignment Length: 1196
• Identity: 275/1196 - (22%)
• Similarity: 477/1196 - (39%)
• Gaps: 302/1196 - (25%)

  Fly    51 ENEADFWKFVGKYEAMMRSTG------QP------VLPPRLAEAELSSMQPYHRSKHLALRLD-A 102
            ::.|||:.|...::..:.|.|      :|      .||.| |.......:.:.|.:...|... .
Mosquito     4 DDVADFFDFSKPFKRTVVSGGYINGAVKPQKLNIQTLPER-AHQGTEYAEKFCREEEARLMEGWV 67

  Fly   103 DELLQ-------EARDQMQSQFRHILLVYLDFRQTEKFQRIR------------KLRQTQRNLPI 148
            ||.|.       |..|.|.|...         ..|:..||:|            ....|...|.|
Mosquito    68 DETLNKSTASRLEQVDDMSSVME---------EDTQHLQRVRAKELMEPLFSRYNFTVTPNRLTI 123

  Fly   149 ARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYR-----SIACTQPRRLACVSLCKRV 208
            .:.::|:.:|:..:.||::.|.|||||:|||||||.:..|.     :|..||||::|..|:.:||
Mosquito   124 HQSKQDILKAIRENPVVVLQGMTGCGKTTQVPQYLLEDAYNRKEWCNIVVTQPRKIAASSIARRV 188

  Fly   209 AHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGD 273
            |.|.....||.|.|::..:...::.|.:.::|.|:||.:|..:.::..|..:||||:|||.:..|
Mosquito   189 AEERNCALGSLVGFKVGLKEMVSEDTRLTYVTTGVLLNKLITSKSISSYTHIILDEVHEREVDMD 253

  Fly   274 FLLGVTKCLLRARPQLKLILMSATINVELFHGYFGEEGARLVQVPGRLF------------PIKL 326
            |||.:.:.||......|:|||||||....|..||...|      |..||            .:.:
Mosquito   254 FLLIIVRRLLATMRNTKIILMSATIESSEFAQYFKIPG------PNSLFAPQLAVSNVTQHDVSV 312

  Fly   327 RYLPPPALELKAGQATSKRSQRNRIDPAPFV--QVLSLIDQ---QYPTSERGD----VLIFVSGV 382
            .||..  ||......|.|..|.:..:...|:  :|..:.|:   ::.::...|    :::|:.|:
Mosquito   313 YYLED--LEKLRVDFTIKYEQPDVHEKMYFLAAKVAVVCDRFIDEFESASTIDYKPSIIMFLPGI 375

  Fly   383 NEIESVVEAVHEY-------ATEQTHWLVLPLHSGQAIADQSKVFDYAPEGMRKCIVSTNIAETS 440
            ||||.:.|.:..:       :.|||.:.:|.|||.....:|:.||.....|.||.|:||||||:|
Mosquito   376 NEIERMAEVLRNFLGDSNVNSQEQTKFTILKLHSMLPSEEQALVFTKPSPGYRKVILSTNIAESS 440

  Fly   441 LTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVCFRLYTAEQYNA 505
            :|:..|:||:|....:.:..|.......|:..|.|:::..||.||.||...|..:||.....:..
Mosquito   441 ITIPDVKFVIDFCLHRVLVADTLNNFTTLRTQWASRNNCIQRAGRCGRVMNGRVYRLVNKHFFEH 505

  Fly   506 FEAYP-TPEIYRVPLDTMLL--QMVSMGLPDVRAFPFIEAPETERIEQTILALKQHCALSVEEK- 566
            ..|.. .||:.|.||..::|  :::.||.|.......:..|....:..|:|.||:..||....|
Mosquito   506 GMAQSIEPEMVRCPLSNVVLKTKLLDMGPPHTILALAMSPPNLSDVSNTVLQLKELGALLRTAKG 570

  Fly   567 --------ITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQNPLTNRAHTDQRCV 623
                    ||.||..::.||:::.:.|::::|.||..:|:.:.:||.::|:| :..:..|.:...
Mosquito   571 VYDLQDGDITYLGNIMSTLPLDIHLAKLVVLGYVFSVLEEAIVIAAGMNVKN-IFCQLRTIEALR 634

  Fly   624 RERESLESDHGDLFTLVRLYNVWVQLKMRRDG--TRQWCRRLGIEEQRFYEVTKLRQQFQRILES 686
            .:|........|...::..||.|..::.:..|  |..||.|..::.:...|:.:|.|:....|::
Mosquito   635 VKRHFANGSASDGIAILNAYNWWRSIREQGTGGDTTDWCNRYMLDRKSLIEMAELVQEITMRLKT 699

  Fly   687 CGM-VVASDSDSQLTSAERATRHGELRQLKAMKRRQRFEQPRQRKLLKQSAGRVAEDEEEQEEAQ 750
            ..: ||:..::::.|..||
Mosquito   700 ANIRVVSGANNARWTDRER---------------------------------------------- 718

  Fly   751 GDDMRDVDFRLRFDPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAI---------SDEFNY 806
                                            .|:||:::...|||...|         ||:..|
Mosquito   719 --------------------------------TVVLKVVMAGAFYPNYFIPTCVTDRELSDKMVY 751

  Fly   807 CKGGGQQFFHTRLKPFVLQHPNSQFAKHFELLKLTESDLLPKPDFYTPKLPLSKRHQL------- 864
            .:.||:..|.|   .|.....:|.:     :..|..:::..   ..|.:.|.|::||:
Mosquito   752 TEIGGRDPFST---VFFCGFDHSNY-----IGPLYRNEIRA---LLTERKPTSEKHQVKVEFERS 805

  Fly   865 -----LCYQ---------SLLE------TAKPYLINCIRLPAA---QTLLLFSFAIDTNAGITQI 906
                 :.:|         ||.|      ...|.:...|:|...   |:.||.....|..|..|:.
Mosquito   806 TNKIFVQFQYPPDQQSGKSLYEERNSADRVHPGVYEAIKLRQLRHNQSELLVMHHNDAVAYATEH 870

  Fly   907 ACDGWLGLD-----LPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQESPS----HSSDDRS 962
            ....|...:     :.:|.:.:     ::|....|:|     :....:..|.|:    ...|:::
Mosquito   871 RLGVWRNHEWHPRSVEIPNAHL-----SVEPPIHWNR-----VTATVTHVEHPNKFYLRPHDEKN 925

  Fly   963 SALWQDLVDYM--------ALDVAYAI--RRLLPADIKRLYTHQAPSARLAELKE---------N 1008
            ..::.|:::.:        |....||.  |.::.|.:..:.|.:...|:|  |::         .
Mosquito   926 DNIYHDIMEKLNGCDAVLRAFPEGYAFKQRDIVAAPLPNMVTGKMARAKL--LQQCLVRGVEHWT 988

  Fly  1009 PFAVDFPMTPNEEKGGLNVS-----------------EHVVYSCLAEQQ----------WTTAMD 1046
            .|.:||.:|     .|::|.                 :.|..:.|||.|          |   |:
Mosquito   989 VFFMDFGLT-----AGVSVKSFRQLRGTPLDMFTKFPDRVFLASLAEVQPSAVRSPKDVW---ME 1045

  Fly  1047 ATLRAEPWQCTRCDFELEEFDVLEQL 1072
            .|::..........|::|.:.|:.::
Mosquito  1046 ETIKHFRQLVHGQQFDVEVYSVVNRV 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	160/518 (31%)
		OB_NTP_bind	792..897	CDD:400182	29/143 (20%)
spn-E	XP_312084.5	HrpA	118..>663	CDD:441249	166/553 (30%)
		TUDOR	905..1029	CDD:425754	20/130 (15%)
		C2H2 Zn finger	1430..1452	CDD:275371