Protein Alignment CG32533 and TDRD9

DIOPT Version :10

• Sequence 1: NP_728244.1
• Gene: CG32533 / 32933
• FlyBaseID: FBgn0052533
• Length: 1139
• Species: Drosophila melanogaster
• Sequence 2: NP_694591.2
• Gene: TDRD9 / 122402
• HGNCID: 20122
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 1213
• Identity: 302/1213 - (24%)
• Similarity: 494/1213 - (40%)
• Gaps: 328/1213 - (27%)

  Fly    47 RSLVENEADFWKFVGKYEAMMRSTGQP----------------VLP--------PRLAEAELSSM 87
            |.|...:.:.|..:||....:...|.|                |.|        |.||:|.....
Human     3 RKLTIEQINDWFTIGKTVTNVELLGAPPAFPAGAAREEVQRQDVAPGAGPAAQAPALAQAPARPA 67

  Fly    88 QPYHRSKHLALRLDADELLQEARDQMQSQFRHILLVYLDFRQT-------------EKFQRIRKL 139
            ..:.||  |:.|....|.:.:.| |:::|       .||..::             .|...:..:
Human    68 AAFERS--LSQRSSEVEYINKYR-QLEAQ-------ELDVCRSVQPTSGPGPRPSLAKLSSVTCI 122

  Fly   140 RQT---QRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDF-----GYRSIACTQP 196
            ..|   ..:|||:|:::::...::::.|||:.|.||.|||||:|||:.|.     .|.||..|||
Human   123 PGTTYKYPDLPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILDHYVQRSAYCSIVVTQP 187

  Fly   197 RRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDALI 261
            |::...|:.:.::.|.....|..|.:|:..|:..|:.|.::::|.|:||:::..|.:|.::..:|
Human   188 RKIGASSIARWISKERAWTLGGVVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHII 252

  Fly   262 LDEIHERNLFGDFLLGVTKCLLRARPQ-LKLILMSATINVELFHGYFG------EEGARLVQVPG 319
            :||:|||....||||.|.:.|||...: :|::||||||:.:.|..||.      ...|.:.:|.|
Human   253 IDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAVPVQNKMNPAYIFEVEG 317

  Fly   320 RLFPIKLRY-----------LPPPALELKAGQATSKRSQRNRIDP----------APFVQVLSLI 363
            :...::..|           |.|..||                :|          ...:|:...:
Human   318 KPHSVEEYYLNDLEHIHHSKLSPHLLE----------------EPVITKDIYEVAVSLIQMFDDL 366

  Fly   364 DQQYPTS----------ERGDVLIFVSGVNEIESVVEAVHEYATEQTH--WLVLPLHSGQAIADQ 416
            |.:...:          ||..||:|:.|:.||    ..:||..|...|  ..|.||||..|:.:|
Human   367 DMKESGNKAWSGAQFVLERSSVLVFLPGLGEI----NYMHELLTSLVHKRLQVYPLHSSVALEEQ 427

  Fly   417 SKVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQ 481
            :.||.....|.||.|:||||||:|:||..|::|:|....:.:..|.....|.|:..|.||:|.:|
Human   428 NNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQ 492

  Fly   482 RKGRAGRTGPGVCFRLYTAEQY-NAFEAYPTPEIYRVPLDTMLL--QMVSMGLPDVRAFPFIEAP 543
            |||||||...|.|:||...:.: |:...:..||:.|.||.:.:|  :::.||.|.......:..|
Human   493 RKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPP 557

  Fly   544 ETERIEQTILALKQHCALSV----------EEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQ 598
            ....||:|||.||:..||:|          :.::|.|||.||.|||...:||::::|.||..:::
Human   558 GLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLGHVFGCLDE 622

  Fly   599 LLTLAAMLSVQN--PLTNRAHTDQRCVRERESLE-SDHGDLFTLVRLYNVWV------QLKMRRD 654
            .|.:||.||::|  .:..|.|.|.  .|.:.:.. |...|...||..:..|.      :|:..:|
Human   623 CLIIAAALSLKNFFAMPFRQHLDG--YRNKVNFSGSSKSDCIALVEAFKTWKACRQTGELRYPKD 685

  Fly   655 GTRQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVAS-------------------------- 693
             ...|.|...|:.:|..||.:|.::.:..:....|.|.|
Human   686 -ELNWGRLNYIQIKRIREVAELYEELKTRISQFNMHVDSRRPVMDQEYIYKQRFILQVVLAGAFY 749

  Fly   694 -------DSDSQLTSAERATR-------------HGEL--RQLKAMKRR---------------- 720
                   ..|.::...|.|.:             :|.|  :||:::.|:
Human   750 PNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIPPYGFLYYKQLQSLFRQCGQVKSIVFDGAKAFV 814

  Fly   721 -------QRFEQ-PRQRKLLKQSAGRVAED------EEEQEEAQGDDMR-------DVDFRLR-F 763
                   :||:. |.....:|.|..:|:.:      ||.:.:.||.::.       :|||:.: .
Human   815 EFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEGKVQGMNVSKLRNTRVNVDFQKQTV 879

  Fly   764 DPRQLALLERSSRLDRHSVVVLLKLLLGSGFYPQLAISDEFNYCKGGGQQFFHTRLKPFVLQHPN 828
            ||.|::.    :..||...|..|.|.:           |.....:.|  .|:..|     :...|
Human   880 DPMQVSF----NTSDRSQTVTDLLLTI-----------DVTEVVEVG--HFWGYR-----IDENN 922

  Fly   829 SQFAKHF--ELLKLTESDLLPKPDFYTPKLPLSKRHQLLCYQSLLETAKPYLINCIRLPAAQTLL 891
            |:..|..  |:.:||   |:|        ||......|:|.....:..|.      |...||.|.
Human   923 SEILKKLTAEINQLT---LVP--------LPTHPHPDLVCLAPFADFDKQ------RYFRAQVLY 970

  Fly   892 LFS-----FAIDTNAGITQIACDGWLGLDLPMPGSGMELLRRAIELRRRWSRLLYDKLDDLKSKQ 951
            :..     |.:|..   .:...|  |.|.:.:|...:||..:|:|.          |:..::...
Human   971 VSGNSAEVFFVDYG---NKSHVD--LHLLMEIPCQFLELPFQALEF----------KICKMRPSA 1020

  Fly   952 ES---PSHSSDDRS---------------------SALWQDLVDYMALDVAYAIRRLLPADIKRL 992
            :|   ..|.||..|                     |.|..|:..|..:..|..||.:|   |::.
Human  1021 KSLVCGKHWSDGASQWFASLVSGCTLLVKVFSVVHSVLHVDVYQYSGVQDAINIRDVL---IQQG 1082

  Fly   993 Y------------THQAPSARLAELKEN--PFAVDFPMTPNEE 1021
            |            :|:......::..||  ..:|.|||..:|:
Human  1083 YAELTEESYESKQSHEVLKGLFSKSVENMTDGSVPFPMKDDEK 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_728244.1	HrpA	145..>619	CDD:441249	174/533 (33%)
		OB_NTP_bind	792..897	CDD:400182	22/111 (20%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..62		5/25 (20%)
		HrpA	130..>716	CDD:441249	190/608 (31%)
		DEXHc_TDRD9	132..315	CDD:350746	65/182 (36%)
		DEAH box. /evidence=ECO:0000250|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Tudor_TDRD9	905..1005	CDD:410502	27/128 (21%)