DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32533 and dhx37

DIOPT Version :9

Sequence 1:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	739	Identity:	200/739 - (27%)
Similarity:	341/739 - (46%)	Gaps:	169/739 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 QRIRKLRQTQRNLPIARFRKDLREALDTSRVVIVAGDTGCGKSTQVPQYLYDFGYRS----IACT 194
            :|:.::::.:..||:....:.:.||:.....|::.|:||.||:|||||:||:.|:.|    |..|
Zfish   241 ERLPEIQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGIIGVT 305

  Fly   195 QPRRLACVSLCKRVAHELLDDYGSRVAFQIRFERSRTKLTNILFITEGLLLRQLAVAANLDQYDA 259
            :|||:|.:|:..|||.|:....|. |::|||:|.:.|:.|.|..:|:|:||:::.....|.:|..
Zfish   306 EPRRVAAISMSHRVATEMNLSSGV-VSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSV 369

  Fly   260 LILDEIHERNLFGDFLLGVTKCLLRARPQ----LKLILMSATINVELFHGYFGEEGARLVQVPGR 320
            :|:||.|||:::.|.|:|:...::..|.:    :|||:||||:.||.|     .|..||..
Zfish   370 IIIDEAHERSVYTDILIGLLSRIVPLRNKKGLPMKLIIMSATLRVEDF-----TENKRLFS---- 425

  Fly   321 LFPIKLRYLPPPALELKAGQAT-----SKRSQRNRIDPAPFVQVLSLIDQQYPTSERGDVLIFVS 380
                    .|||.::::|.|..     :||:..:......|.::.. |.:..|.   |.:|:|::
Zfish   426 --------SPPPVIKVEARQFAVTVHFNKRTPMDDYTGETFRKICK-IHRMLPP---GGILVFLT 478

  Fly   381 GVNEIESVVEAVHE---YATEQTH----------------------------------------- 401
            |..|:.||...:.:   |...:.|
Zfish   479 GQAEVHSVCRRLRKAFPYKPNREHTDMMETEEDLKKSKRAKKKNVSLPRINLDNYSALPVDEGDE 543

  Fly   402 -------------------------------------WLVLPLHSGQAIADQSKVFDYAPEGMRK 429
                                                 ..||||:|..|...|:|||...|.|.|.
Zfish   544 DRQAGIDEDDGEGSDLELELGDHPDTDHEEKADPSIPLYVLPLYSLLAPEQQAKVFRPPPAGSRL 608

  Fly   430 CIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQRKGRAGRTGPGVC 494
            |:|:||:||||||:.|:::|||.|:||:..:|........|..|:|::||:||.||||||.||.|
Zfish   609 CVVATNVAETSLTIPGIKYVVDCGRVKKRFYDRVTGVSSFKVTWISQASANQRAGRAGRTEPGHC 673

  Fly   495 FRLYTAEQYNAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETERI---EQTILAL- 555
            :|||::..:..|..:...||.|.|::.::|||..:.:..|..|||...|.:|.:   |:.:::|
Zfish   674 YRLYSSAVFGDFSLFSEAEITRRPVEDLVLQMKDLNIEKVVNFPFPTPPSSEALIAAEELLISLG 738

  Fly   556 -----KQHCALSVEEK------ITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSVQ 609
                 .:|..||..||      |:||||::|..||.....|||.:|.....::.::|:.:.::|:
Zfish   739 ALEKPARHGRLSEMEKARLSCPISPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVR 803

  Fly   610 NPLTNRAHTDQRCVRERESLESDHGDLFTLVRLYNVW-----------VQLKMRRDG-------T 656
            ....:   .|:....|.|:::.. |.....|::..:|           :.:.:...|       |
Zfish   804 EIFED---YDRPAGSEEENVKMS-GKKARSVQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLT 864

  Fly   657 RQWCRRLGIEEQRFYEVTKLRQQFQRILESCGMVVASDSDSQLTSAERATRHGE---LRQL---- 714
            .|:|...|:..:...|:.:||.|....:.:    |.:|:|..:.:........:   |||:
Zfish   865 PQFCEENGLRFKAMLEIRRLRGQLTNAVNA----VCADADVYVDNKMAPPTEAQVLCLRQIVLAG 925

  Fly   715 --KAMKRRQRFEQ---PRQRKLLK 733
              ..:.||.:.|:   |:.|...|
Zfish   926 LGDHIARRVQAEELLDPKWRNAYK 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	66/179 (37%)
		DEXDc	163..298	CDD:238005	57/142 (40%)
		Helicase_C	358..490	CDD:278689	54/212 (25%)
		HA2	560..640	CDD:214852	22/85 (26%)
		OB_NTP_bind	<792..897	CDD:285018
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	200/739 (27%)
		DEXDc	272..412	CDD:238005	57/140 (41%)
		HELICc	583..667	CDD:197757	41/83 (49%)
		HA2	730..781	CDD:282288	16/50 (32%)
		HA2	761..>813	CDD:214852	15/54 (28%)
		OB_NTP_bind	<918..1004	CDD:285018	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900