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Protein Alignment kek5 and LRIG2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_055628.1	Gene:	LRIG2 / 9860	HGNCID:	20889	Length:	1065	Species:	Homo sapiens

Alignment Length:	848	Identity:	160/848 - (18%)
Similarity:	285/848 - (33%)	Gaps:	267/848 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 NEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRE 137
            |.|:.|:..||.:..:.:.  .|.||..:.::::....|:.:..:|::....|.|||||.|::..
Human   263 NNMEELELEHNNLTRVNKG--WLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTR 325

  Fly   138 LHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLR---QVQLHVFAGTMALSA 199
            |....|.||..|..:.:.:|.:..:.:.:|..||.|..::.|||.:.   :.....|||..:|:.
Human   326 LDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTK 390

  Fly   200 ISLEQNRLSHLHKETFKDLQKLMHL--------SLQGNAWN---------------CSCELQDFR 241
            :.|:.|::..:.|:.|..|:.|.||        |:|.||::               |.|.|:...
Human   391 LILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLL 455

  Fly   242 DFAISKRL-YTPPTDCQEPPQLRGKLWSEVPSENFAC----RPRILGSVRSFIEANHDNISLPCR 301
            .:.:.... ::....|..|..|.|:....|..::|.|    :|:|.....:.|.....|::|.|.
Human   456 QWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCT 520

  Fly   302 IVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVL--TSELRIVGVRASDKGAYTCVA 364
            .|.|....::.|:.|.....||..........|   |..:.|  ||.|.:..|..:|:|.|.|:.
Human   521 AVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQ---QAGEALEYTSILHLFNVNFTDEGKYQCIV 582

  Fly   365 DNR-GGRAEAEFQLLV----------------SGDYAGAVSASDGMGMGAIGAPTID-------- 404
            .|. |.....:.:|.|                :|..|....|::|.     .||.|.
Human   583 TNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGH-----PAPQISWQKDGGTD 642

  Fly   405 ------------PQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSK 457
                        |:.::|.|..:.|..:                               |:.|..
Human   643 FPAARERRMHVMPEDDVFFIANVKIEDM-------------------------------GIYSCM 676

  Fly   458 MDKTHNGSMLEGSVIMEMQKSLLNEVNPVE-KPPRRTD---IESVDGGDDVLEIKKTLLDDTVYV 518
            ...|..|.....|:.:....|.   :.|:| |...|.:   ::.:.||.....:..|..|..:.|
Human   677 AQNTAGGLSANASLTVLETPSF---IRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLV 738

  Fly   519 ANHS----------------RDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPARVPP 567
            ....                .|....:..||:|..|.|. |.|::..
Human   739 TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERG-HIYLNVI------------------ 784

  Fly   568 TSPSMQSSQSNIPDQ---------------------------VIYGIR-----------SPPSLT 594
            :||:..||||:|..:                           |||.:|           ...:|.
Human   785 SSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLP 849

  Fly   595 SPVYTHMTPHGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHH-- 657
            :.:.::::..|     |::.|..|:                  |:.:...|.||......:.|
Human   850 ADIPSYLSSQG-----TLSEPQEGY------------------SNSEAGSHQQLMPPANGYIHKG 891

  Fly   658 --------------------HQQQQQ--------QQQQQQHPLATTSPFLPAP--VVYSPATGVV 692
                                :.:.::        ::......|::....:|..  :|:.|.....
Human   892 TDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTA 956

  Fly   693 MKQGYMTIPRKPRAPSWAPSTSGAAGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYD---N 754
            ::.   .||...|.||..|:...       ::||.:.|::....||       || .||::   .
Human   957 LES---LIPSANREPSAFPTNHE-------RISEKKLPSTQMSGET-------LQ-RPVWNINRE 1003

  Fly   755 LGL 757
            |||
Human  1004 LGL 1006

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.