DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRRC4B

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001073926.1	Gene:	LRRC4B / 94030	HGNCID:	25042	Length:	713	Species:	Homo sapiens

Alignment Length:	869	Identity:	174/869 - (20%)
Similarity:	263/869 - (30%)	Gaps:	330/869 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GVLVVLMALPPP-------------TAGTTDWMQSCG-TCHCQWNSGKKSADCKNKALTKIPQDM 71
            |.|:.|....||             ..|.:....||. .|.|...:.:  ..|..:.|.::|..:
Human    22 GALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR--VICTRRDLAEVPASI 84

  Fly    72 SNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIR 136
            ....:.|:...|.|..:|.:.|  ..|.::..:.|....::::...||.||..|..|:|..||:.
Human    85 PVNTRYLNLQENGIQVIRTDTF--KHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLT 147

  Fly   137 ELHPGTFAGLEKLRNVIINNNEIEVLPNHLF----------------------------VNLSFL 173
            .:....|..|.|||.:.:.||.||.:|::.|                            |||.:|
Human   148 TVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYL 212

  Fly   174 S-------------------RIEFRNNRLRQVQLHVFAGTMALSAI------------------- 200
            :                   .:|...|||..::...|.|..:|..:
Human   213 NLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLK 277

  Fly   201 SLEQNRLSH-----LHKETFKDLQKLMHLSLQGNAWNCSCE-------LQDFRDFAISKRLYTPP 253
            |||:..|||     |..:.|..|.:|..:.|..|.|:|:|:       |::           |.|
Human   278 SLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKE-----------TVP 331

  Fly   254 TD------CQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHD-NIS------LPCRIVGS 305
            ::      |..|..|:|:...|:...:|.|...::      :|...| |::      |.|| .|:
Human   332 SNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVI------VEPPTDLNVTEGMAAELKCR-TGT 389

  Fly   306 PRPNVTWVYNKRPLQQYDP-RVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGG 369
            ...:|.|:.....|..:.. |||:           |.:....|....|...|.|.|||:..|..|
Human   390 SMTSVNWLTPNGTLMTHGSYRVRI-----------SVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443

  Fly   370 RAEAEFQLLVS----------GDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLL 424
            ...|...|.||          |...|....|.|:|.|:.|              ....||
Human   444 NTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGG--------------YTYFTT----- 489

  Fly   425 LVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEK- 488
             |.|.||                                                  |..|.|:
Human   490 -VTVETL--------------------------------------------------ETQPGEEA 503

  Fly   489 -PPRRTDIE----SVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTT-TPRSRHTYVD 547
             .||.|:.|    :.||                 |....|..:|...|.|.||. .|||..
Human   504 LQPRGTEKEPPGPTTDG-----------------VWGGGRPGDAAGPASSSTTAPAPRSSR---- 547

  Fly   548 DAYANSLPPDLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTM 612
                    |...||      |.|....:::.:.|           |...:.|.....|.:...|.
Human   548 --------PTEKAF------TVPITDVTENALKD-----------LDDVMKTTKIIIGCFVAITF 587

  Fly   613 TAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSP 677
            .|.              :.|:|          .::|::|.|.|.||...:..:      :.....
Human   588 MAA--------------VMLVA----------FYKLRKQHQLHKHHGPTRTVE------IINVED 622

  Fly   678 FLPAPVVYSPATGVVMKQG-------YMTIPRKPRAP---------------SWAPSTSGAAGHG 720
            .|||....|.|....:..|       ::.:|...|..               |..||..|..|.|
Human   623 ELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKG 687

  Fly   721 SIQLSE------FQSPTSPNPSET 738
            ...|:.      |:|.:..|..||
Human   688 PPGLNSIHEPLLFKSGSKENVQET 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/83 (28%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	17/59 (29%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	23/124 (19%)
		leucine-rich repeat	149..172	CDD:275380	11/50 (22%)
		leucine-rich repeat	173..196	CDD:275380	7/41 (17%)
		LRR_8	197..>229	CDD:290566	12/55 (22%)
		leucine-rich repeat	197..220	CDD:275380	10/46 (22%)
		LRRCT	229..277	CDD:214507	13/60 (22%)
		Ig	296..376	CDD:143165	21/86 (24%)
LRRC4B	NP_001073926.1	LRRNT	57..90	CDD:214470	6/34 (18%)
		LRR	<76..297	CDD:227223	47/222 (21%)
		LRR 1	87..108		5/22 (23%)
		leucine-rich repeat	88..111	CDD:275380	6/24 (25%)
		LRR 2	111..132		3/20 (15%)
		leucine-rich repeat	112..135	CDD:275380	5/22 (23%)
		LRR 3	135..156		6/20 (30%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		LRR 4	159..180		9/20 (45%)
		leucine-rich repeat	160..183	CDD:275380	8/22 (36%)
		LRR 5	183..205		0/21 (0%)
		leucine-rich repeat	184..208	CDD:275380	0/23 (0%)
		LRR 6	208..229		3/20 (15%)
		leucine-rich repeat	209..230	CDD:275380	2/20 (10%)
		LRR 7	230..251		5/20 (25%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR 8	254..275		1/20 (5%)
		leucine-rich repeat	255..278	CDD:275380	1/22 (5%)
		LRR 9	278..299		8/20 (40%)
		leucine-rich repeat	279..300	CDD:275380	7/20 (35%)
		LRRCT	311..361	CDD:214507	13/60 (22%)
		I-set	364..453	CDD:254352	25/106 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..551		19/82 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..713		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910