DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and LGR5

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_003658.1	Gene:	LGR5 / 8549	HGNCID:	4504	Length:	907	Species:	Homo sapiens

Alignment Length:	387	Identity:	98/387 - (25%)
Similarity:	154/387 - (39%)	Gaps:	79/387 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RLGMILLLLGVLVVLMALPPPTAGTTDWMQSCGT-CHCQWNSGKK--SADCKNKALTKIPQDMSN 73
            |||::|.|..:|.:......|.:|..  ::.|.| |||: ..|:.  ..||.:..|:::|.::|.
Human     5 RLGVLLSLPVLLQLATGGSSPRSGVL--LRGCPTHCHCE-PDGRMLLRVDCSDLGLSELPSNLSV 66

  Fly    74 EMQVLDFAHNQI--------PELR-REEFLLA-------------GLPNVHKIFLRNCTIQEVHR 116
            ....||.:.|.|        |.|| .||..||             ||.::..:.|:|..::.|..
Human    67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPT 131

  Fly   117 EAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNN 181
            ||.:.|..|..|.|..|.|..:.|..|:||..||::.:::|.:..:|...|.:||.|..:....|
Human   132 EALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN 196

  Fly   182 RLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAIS 246
            ::..:..:.|....:|..:.|..||:..|.|:.|..|..|..|.|..|      .|.:|
Human   197 KIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYN------NLDEF------ 249

  Fly   247 KRLYTPPTDCQEPPQLR-----GKLWSEVPSENFACRPRILGSVRSFIEAN-HDNISLPCRIVGS 305
                  ||..:....|:     ......:|.:.|...|       |.|..: :||   |.:.||
Human   250 ------PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNP-------SLITIHFYDN---PIQFVG- 297

  Fly   306 PRPNVTWVYNKRPLQQYDPRVRVLT--SVEQMPEQPSQVLTSELR---IVGVRASDKGAYTC 362
                       |...|:.|.:|.||  ...|:.|.|....|:.|.   :.|.:.|......|
Human   298 -----------RSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVC 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	31/105 (30%)
		leucine-rich repeat	76..100	CDD:275380	13/45 (29%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	8/52 (15%)
		Ig	296..376	CDD:143165	17/72 (24%)
LGR5	NP_003658.1	LRRNT	33..70	CDD:214470	11/37 (30%)
		leucine-rich repeat	68..91	CDD:275380	6/22 (27%)
		PLN00113	71..>426	CDD:215061	79/318 (25%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		leucine-rich repeat	116..139	CDD:275380	6/22 (27%)
		leucine-rich repeat	140..163	CDD:275380	9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	8/39 (21%)
		leucine-rich repeat	259..282	CDD:275380	4/29 (14%)
		leucine-rich repeat	283..304	CDD:275380	8/35 (23%)
		leucine-rich repeat	307..353	CDD:275378	11/42 (26%)
		leucine-rich repeat	354..375	CDD:275378
		leucine-rich repeat	376..389	CDD:275378
		leucine-rich repeat	400..423	CDD:275378
		leucine-rich repeat	445..459	CDD:275378
		7tmA_LGR5	558..831	CDD:320485
		TM helix 1	559..585	CDD:320485
		TM helix 2	592..617	CDD:320485
		TM helix 3	637..667	CDD:320485
		TM helix 4	679..701	CDD:320485
		TM helix 5	721..750	CDD:320485
		TM helix 6	759..789	CDD:320485
		TM helix 7	799..824	CDD:320485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910