DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LINGO1

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	596	Identity:	121/596 - (20%)
Similarity:	193/596 - (32%)	Gaps:	216/596 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMA--LPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQV 77
            ::||:||.::...|  .||               .|:.::..::..|..|....:|:.:..|.::
Human    26 ILLLVLGSVLSGSATGCPP---------------RCECSAQDRAVLCHRKRFVAVPEGIPTETRL 75

  Fly    78 LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGT 142
            ||...|:|..|.::||  |..|::.::.|....:..|...||..|..|..|.|..||::.:..|.
Human    76 LDLGKNRIKTLNQDEF--ASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGV 138

  Fly   143 FAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQ--- 204
            |.||..|..:.|:.|:|.:|.:::|.:|..|..:|..:|.|..:....|:|..:|..::||:
Human   139 FTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNL 203

  Fly   205 -----NRLSHLH----------------KETFKDLQKL--------------------------- 221
                 ..|||||                ..:||.|.:|
Human   204 TSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSL 268

  Fly   222 --------------------------------------MH------------------------- 223
                                                  :|
Human   269 SITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRG 333

  Fly   224 ------------------------------LSLQGNAWNCSCELQDFRDFAISKRLY------TP 252
                                          |.|..|...|.|.|     ..:.:|.:      ..
Human   334 LNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRL-----LWVFRRRWRLNFNRQQ 393

  Fly   253 PTDCQEPPQLRGKLWSEVPS----ENFACRP---RILGSVRSFIEANHDNISLPCRIVGSPRPNV 310
            || |..|..::||.:.:.|.    ..|.||.   |...:.:.|::..| .:...||..|.|.|.:
Human   394 PT-CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGH-TVQFVCRADGDPPPAI 456

  Fly   311 TWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEF 375
            .|:..::.|.......|:..    .|:.     |.|:|...|:  |.|.|.|:|.|.||......
Human   457 LWLSPRKHLVSAKSNGRLTV----FPDG-----TLEVRYAQVQ--DNGTYLCIAANAGGNDSMPA 510

  Fly   376 QLLV---SGDYA-------GAVSASDGMGMGAIGAPTID-PQTNMFLIICLIITTLL-------L 422
            .|.|   |.|:.       ..:|...|.|.......|:. |    |.|..|||.|.:       :
Human   511 HLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFP----FDIKTLIIATTMGFISFLGV 571

  Fly   423 LLLVAVLTLFW 433
            :|...||...|
Human   572 VLFCLVLLFLW 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	26/83 (31%)
		leucine-rich repeat	76..100	CDD:275380	8/23 (35%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	16/66 (24%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	15/175 (9%)
		leucine-rich repeat	197..220	CDD:275380	11/46 (24%)
		LRRCT	229..277	CDD:214507	13/57 (23%)
		Ig	296..376	CDD:143165	21/79 (27%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	7/48 (15%)
		LRR	<66..371	CDD:227223	54/306 (18%)
		LRR 1	72..93		8/22 (36%)
		leucine-rich repeat	73..96	CDD:275380	8/24 (33%)
		LRR 2	96..117		4/20 (20%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		LRR_8	120..179	CDD:338972	19/58 (33%)
		LRR 3	120..141		7/20 (35%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		LRR 4	144..165		6/20 (30%)
		leucine-rich repeat	145..192	CDD:275380	13/46 (28%)
		LRR 5	168..189		5/20 (25%)
		LRR 6	192..213		4/20 (20%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		LRR 7	216..237		1/20 (5%)
		leucine-rich repeat	217..264	CDD:275380	4/46 (9%)
		LRR 8	264..285		0/20 (0%)
		leucine-rich repeat	265..288	CDD:275380	0/22 (0%)
		LRR 9	288..309		0/20 (0%)
		leucine-rich repeat	289..312	CDD:275380	1/22 (5%)
		LRR 10	312..333		0/20 (0%)
		leucine-rich repeat	313..336	CDD:275380	0/22 (0%)
		LRR 11	336..357		0/20 (0%)
		leucine-rich repeat	337..357	CDD:275380	0/19 (0%)
		PCC	341..>421	CDD:188093	15/85 (18%)
		Ig	439..514	CDD:386229	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910