DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and SLITRK2

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001137475.1 Gene:SLITRK2 / 84631 HGNCID:13449 Length:845 Species:Homo sapiens


Alignment Length:854 Identity:158/854 - (18%)
Similarity:285/854 - (33%) Gaps:288/854 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 CHCQWNSGKKSADCKNKALTKI-----PQ----------------------DMSNEMQVLDFAHN 83
            |.|:......:.:|:||..|.:     ||                      :.||.: .|...:|
Human    33 CLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAV-TLHLGNN 96

  Fly    84 QIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEK 148
            .:.|:|...|  :||..:.::.|.|..::.:..:.|.||..|..|....|.|..:..|.|:.|.|
Human    97 GLQEIRTGAF--SGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNK 159

  Fly   149 LRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKE 213
            |:.:|:|:|.:..||:::| ....|:.::.|.|||:.:.   |||.            |.|    
Human   160 LKVLILNDNLLLSLPSNVF-RFVLLTHLDLRGNRLKVMP---FAGV------------LEH---- 204

  Fly   214 TFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACR 278
                :..:|.:.|:.|.|||:|:|...:.:..:..::.....|:.|.:|.||..:::..::..  
Human   205 ----IGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLC-- 263

  Fly   279 PRILGSVRSFIEANHD--------------------NISLPCRIVGSPRPNVT-----------W 312
            ||...|..|...::.|                    ..|.|.::...|.|.||           .
Human   264 PRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIM 328

  Fly   313 VY-NKRPLQQYDP------------------RVRVLTSVEQMPEQPSQVLTSELRIVG------- 351
            || .|.|:....|                  :.|..|::..:  ||......:|.:.|       
Human   329 VYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL--QPKPTSPKKLYLTGNYLQTVY 391

  Fly   352 -------------------VRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAV--SASDGMGM 395
                               :....:||:|.:...|        :|.::|:|...:  |..||:  
Human   392 KNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLR--------RLYLNGNYLEVLYPSMFDGL-- 446

  Fly   396 GAIGAPTIDPQTNMFLI----ICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISS 456
                      |:..:|.    :...|..|....|:.:..||.....:::...:  :..|..|...
Human   447 ----------QSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDN--IFGGTALTRL 499

  Fly   457 KMDKTHNGSM--------LEGSVIMEMQKS----------------------LLNEVNPVEKPPR 491
            .:...|...:        |...:.:::|::                      ::|||. .|.|.:
Human   500 NLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVT-CESPAK 563

  Fly   492 RT-DIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLP 555
            .. :|....|.:.:......|.|.||...||:.|             ||||              
Human   564 HAGEILKFLGREAICPDSPNLSDGTVLSMNHNTD-------------TPRS-------------- 601

  Fly   556 PDLLAFPARVPPTSPSMQSSQSNIPDQVIY-------------------GIRSPPSLTS--PVYT 599
              |...|:..|.....:..|...:...|::                   |:.|.|..|:  .|.:
Human   602 --LSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNNLDVSS 664

  Fly   600 HMTPHGIYGTKT----------MTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQH 654
            ....:|.|.|:|          ...|..|.| .|:|       |..........::..||:    
Human   665 FQLQYGSYNTETHDKTDGHVYNYIPPPVGQM-CQNP-------IYMQKEGDPVAYYRNLQE---- 717

  Fly   655 HHHHQQQQQQQQQQQHPLATTS----------PFLPAPVVYS---------PATGVVMKQGYMTI 700
             ..:...::::::...|..|.|          |..| .::|.         |:.|:| ...:.|:
Human   718 -FSYSNLEEKKEEPATPAYTISATELLEKQATPREP-ELLYQNIAERVKELPSAGLV-HYNFCTL 779

  Fly   701 PRKPRAPSW 709
            |::..|||:
Human   780 PKRQFAPSY 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 24/83 (29%)
leucine-rich repeat 76..100 CDD:275380 7/23 (30%)
LRR_8 99..159 CDD:290566 17/59 (29%)
leucine-rich repeat 101..124 CDD:275380 5/22 (23%)
LRR 122..145 CDD:197688 7/22 (32%)
leucine-rich repeat 125..148 CDD:275380 7/22 (32%)
LRR_8 148..207 CDD:290566 16/58 (28%)
leucine-rich repeat 149..172 CDD:275380 7/22 (32%)
leucine-rich repeat 173..196 CDD:275380 8/22 (36%)
LRR_8 197..>229 CDD:290566 4/31 (13%)
leucine-rich repeat 197..220 CDD:275380 2/22 (9%)
LRRCT 229..277 CDD:214507 11/47 (23%)
Ig 296..376 CDD:143165 21/135 (16%)
SLITRK2NP_001137475.1 LRR 1 63..84 0/20 (0%)
leucine-rich repeat 67..87 CDD:275380 0/19 (0%)
LRR_RI <82..>217 CDD:238064 41/161 (25%)
LRR_8 86..146 CDD:290566 17/62 (27%)
LRR 2 87..108 6/23 (26%)
leucine-rich repeat 88..111 CDD:275380 7/25 (28%)
LRR 3 111..132 3/20 (15%)
leucine-rich repeat 112..135 CDD:275380 5/22 (23%)
LRR_8 135..193 CDD:290566 18/58 (31%)
LRR 4 135..156 6/20 (30%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
LRR 5 159..180 8/21 (38%)
leucine-rich repeat 160..181 CDD:275380 7/21 (33%)
Required for interaction with PTPRD. /evidence=ECO:0000250|UniProtKB:Q810C0 167..215 16/71 (23%)
leucine-rich repeat 208..369 CDD:275380 31/162 (19%)
TPKR_C2 216..>252 CDD:301599 9/35 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..321 11/59 (19%)
leucine-rich repeat 370..400 CDD:275380 4/31 (13%)
LRR 7 376..397 2/20 (10%)
LRR_8 399..459 CDD:290566 12/79 (15%)
LRR 8 400..421 2/20 (10%)
leucine-rich repeat 401..424 CDD:275380 3/22 (14%)
LRR_4 423..466 CDD:289563 10/62 (16%)
LRR 9 424..445 5/28 (18%)
leucine-rich repeat 425..448 CDD:275380 7/42 (17%)
LRR 10 448..469 3/20 (15%)
leucine-rich repeat 449..468 CDD:275380 3/18 (17%)
LRR 11 472..493 2/22 (9%)
leucine-rich repeat 473..491 CDD:275380 2/19 (11%)
LRR 12 495..516 2/20 (10%)
leucine-rich repeat 496..509 CDD:275378 2/12 (17%)
leucine-rich repeat 521..533 CDD:275378 1/11 (9%)
LRRCT 529..579 CDD:214507 7/50 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 115 1.000 Inparanoid score I4831
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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