DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and SLITRK6

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_115605.2	Gene:	SLITRK6 / 84189	HGNCID:	23503	Length:	841	Species:	Homo sapiens

Alignment Length:	890	Identity:	171/890 - (19%)
Similarity:	303/890 - (34%)	Gaps:	258/890 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SCGT-CHCQWNSGKKSADCKNKALTKIPQDMSNEMQV-------LDFAHNQIPELRREEFLLAGL 98
            ||.: |:|:...|....:|:.|.:     .|.:|:.|       |...:|.:..|...:|  :||
Human    30 SCDSLCNCEEKDGTMLINCEAKGI-----KMVSEISVPPSRPFQLSLLNNGLTMLHTNDF--SGL 87

  Fly    99 PNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLP 163
            .|...|.|....|.::...||.||.:|.:|.::.|.:..|...||.|||.|..:..:||.|.|:.
Human    88 TNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIE 152

  Fly   164 NHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETF-KDLQKLMHLSLQ 227
            ...|..|:.|..:...:|.:..:..::|. .:.|:.:.|..|:|..|....| :.:.:::.|.|:
Human   153 PSAFSKLNRLKVLILNDNAIESLPPNIFR-FVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLE 216

  Fly   228 GNAWNCSCELQDFRDFAISKRLYTPPTD------CQEPPQLRGKLWSEVPSENFACRPRI----- 281
            .|.|.|:|:|...:.:..:    .||..      |..||..:|.:.|.:..|:....|.:
Human   217 DNKWACNCDLLQLKTWLEN----MPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHE 277

  Fly   282 -------LGSVRSFIEANHDN-----ISLPCRIVG------SPRPNVTWVYNKRP---------- 318
                   |.:..|..::....     :.||.:..|      .|...:...|...|
Human   278 DPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSG 342

  Fly   319 --LQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTC-----VADNR-GGRAEAEF 375
              :...:..:..|:.:...|:.|.:::.:...|..:..||...|..     :.:|| ....|..|
Human   343 LLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSF 407

  Fly   376 -------QLLVSGDYAGAVSASDGMGMG---------------AIGAPTIDPQTNMFLIICLIIT 418
                   :|.::|::  ....|.||.:|               .|...|.:|...:.:   |.:.
Human   408 MNLTRLQKLYLNGNH--LTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKV---LYLN 467

  Fly   419 TLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEV 483
            ..||.:|                  ...:.||..|....: ||:..:.|..|.|:: ...||.::
Human   468 NNLLQVL------------------PPHIFSGVPLTKVNL-KTNQFTHLPVSNILD-DLDLLTQI 512

  Fly   484 NPVEKPPRRTDIESVDGGDDVLEI--------KKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPR 540
            :..:.|        .|...|::.:        |.|:.||.:                   .|:|
Human   513 DLEDNP--------WDCSCDLVGLQQWIQKLSKNTVTDDIL-------------------CTSP- 549

  Fly   541 SRHTYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHG 605
               .::|.....:|..::|. |..|  .:|||       |.|..|.:     :|:|..|..|...
Human   550 ---GHLDKKELKALNSEILC-PGLV--NNPSM-------PTQTSYLM-----VTTPATTTNTADT 596

  Fly   606 IYGTKTMTAPHN------------------GFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQ 652
            |..:.|...|.:                  |.:.|...:.|...........|.:...| ||...
Human   597 ILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVH-LQYSM 660

  Fly   653 QHH---HHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRAPSWAPSTS 714
            ..|   ||..::......:||.::      |...||                   |:||:.|.
Human   661 YGHKTTHHTTERPSASLYEQHMVS------PMVHVY-------------------RSPSFGPK-- 698

  Fly   715 GAAGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQGGA 779
                    .|.|.:.......|:......:.|:.|             .:|.|.         |:
Human   699 --------HLEEEEERNEKEGSDAKHLQRSLLEQE-------------NHSPLT---------GS 733

  Fly   780 GQQYSMRDRPLPATPSLTSVSSATNASKIYEPIHELIQQQQQLQQ 824
            ..:|.       .|...|...|..:||.:|   ..:::::::|||
Human   734 NMKYK-------TTNQSTEFLSFQDASSLY---RNILEKERELQQ 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	27/90 (30%)
		leucine-rich repeat	76..100	CDD:275380	7/30 (23%)
		LRR_8	99..159	CDD:290566	20/59 (34%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	8/32 (25%)
		leucine-rich repeat	197..220	CDD:275380	6/23 (26%)
		LRRCT	229..277	CDD:214507	13/53 (25%)
		Ig	296..376	CDD:143165	17/110 (15%)
SLITRK6	NP_115605.2	PLN00113	69..>494	CDD:331614	92/455 (20%)
		leucine-rich repeat	69..89	CDD:275380	6/21 (29%)
		LRR 1	89..110		6/20 (30%)
		LRR_8	92..146	CDD:316378	17/53 (32%)
		leucine-rich repeat	94..113	CDD:275380	6/18 (33%)
		LRR 2	113..134		6/20 (30%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR_8	137..195	CDD:316378	13/58 (22%)
		LRR 3	137..158		6/20 (30%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		LRR 4	161..182		3/21 (14%)
		leucine-rich repeat	162..177	CDD:275380	2/14 (14%)
		LRR 5	184..205		6/20 (30%)
		leucine-rich repeat	185..260	CDD:275380	19/78 (24%)
		leucine-rich repeat	261..412	CDD:275380	21/150 (14%)
		LRR 6	364..385		4/20 (20%)
		leucine-rich repeat	366..388	CDD:275380	4/21 (19%)
		LRR 7	388..409		4/20 (20%)
		LRR_8	411..471	CDD:316378	10/64 (16%)
		LRR 8	412..433		5/22 (23%)
		leucine-rich repeat	413..436	CDD:275380	6/24 (25%)
		LRR 9	436..457		2/20 (10%)
		leucine-rich repeat	437..460	CDD:275380	3/22 (14%)
		LRR_8	459..518	CDD:316378	14/81 (17%)
		LRR 10	460..481		4/41 (10%)
		leucine-rich repeat	461..482	CDD:275380	5/41 (12%)
		LRR 11	483..504		6/21 (29%)
		LRRCT	517..567	CDD:214507	12/81 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4831
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960