DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Slit3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_112611.1	Gene:	Slit3 / 83467	RGDID:	69311	Length:	1523	Species:	Rattus norvegicus

Alignment Length:	657	Identity:	150/657 - (22%)
Similarity:	251/657 - (38%)	Gaps:	165/657 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIF 105
            || ..|.|..|    ..||:.|.||:||.:              :||            .:.:|.
  Rat   279 SCPSACSCSNN----IVDCRGKGLTEIPAN--------------LPE------------GIVEIR 313

  Fly   106 LRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNL 170
            |...:|:.:...||.....|..:|:|.|:|.::.|..|.||:.|.::::..|:|..:|..||..|
  Rat   314 LEQNSIKSIPAGAFIQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGL 378

  Fly   171 SFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSC 235
            ..|..:....|::..::::.|.....|:.:||..|:|..:.|..|..||.:..|.|..|.:.|.|
  Rat   379 VSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDC 443

  Fly   236 ELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFAC------RPRILGSVRSFIEANHD 294
            .|:...|:.....:.|....|..|.:|..|..|::.|:.|.|      |.|.  |...|::
  Rat   444 HLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRF--SSECFMD---- 502

  Fly   295 NISLP--CR----IVGSPRPNVTWVYNKRP-----LQQYDPRVRVLTSVEQMPEQPS--QVLTSE 346
             :..|  ||    ||......::.:.:..|     |:..|..:.||.:.....:.|:  ::..|.
  Rat   503 -LVCPEKCRCEGTIVDCSNQKLSRIPSHLPEYTTDLRLNDNDIAVLEATGIFKKLPNLRKINLSN 566

  Fly   347 LRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFL 411
            .||..||   :||:    |...|..|    |:::|:....:...  |..|..|..|:..::|  |
  Rat   567 NRIKEVR---EGAF----DGAAGVQE----LMLTGNQLETMHGR--MFRGLSGLKTLMLRSN--L 616

  Fly   412 IICLIITTLLLLLLVAVLTLFWYCRRIKTYQKD--TTM--MSGDGLISSKMD-KTHN---GSMLE 468
            |.|:...|...|..|.:|:|  |..||.|....  ||:  :|...|:|:..: ..|.   |..|.
  Rat   617 ISCVNNDTFAGLSSVRLLSL--YDNRITTISPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLR 679

  Fly   469 GSVIM----EMQKSLL------------------NEVNPVEKPPR----RTDIESV----DGG-- 501
            ...|:    ..||...                  ||.|..:..||    .|.:|:|    :.|
  Rat   680 KRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCEGNEENSCQLSPRCPEQCTCVETVVRCSNRGLH 744

  Fly   502 -------DDVLEIKKTLLDDTVYV-ANH--------SRDEEAVSVAMSDTTTTPRSRHTYVDDAY 550
                   .||.|:         |: .||        |...:...:.:|:.:.:..:.||:.:.::
  Rat   745 TLPKGMPKDVTEL---------YLEGNHLTAVPKELSTFRQLTLIDLSNNSISMLTNHTFSNMSH 800

  Fly   551 ANSLPPDLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAP 615
            .::|   :|::            :....||.....|:||...||           ::|....:.|
  Rat   801 LSTL---ILSY------------NRLRCIPVHAFNGLRSLRVLT-----------LHGNDISSVP 839

  Fly   616 HNGFMTL 622
            ...|..|
  Rat   840 EGSFNDL 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	18/83 (22%)
		leucine-rich repeat	76..100	CDD:275380	2/23 (9%)
		LRR_8	99..159	CDD:290566	16/59 (27%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	14/58 (24%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	13/47 (28%)
		Ig	296..376	CDD:143165	21/92 (23%)
Slit3	NP_112611.1	leucine-rich repeat	311..332	CDD:275380	5/20 (25%)
		LRR_4	331..371	CDD:289563	12/39 (31%)
		LRR 8	332..353		7/20 (35%)
		leucine-rich repeat	333..356	CDD:275380	9/22 (41%)
		LRR_8	355..439	CDD:290566	22/83 (27%)
		LRR 9	356..377		6/20 (30%)
		leucine-rich repeat	357..377	CDD:275380	6/19 (32%)
		LRR 10	380..401		3/20 (15%)
		leucine-rich repeat	381..404	CDD:275380	3/22 (14%)
		LRR 11	404..425		7/20 (35%)
		leucine-rich repeat	405..426	CDD:275380	7/20 (35%)
		TPKR_C2	437..>467	CDD:301599	7/29 (24%)
		LRRNT	505..535	CDD:214470	6/29 (21%)
		LRR 12	533..554		4/20 (20%)
		leucine-rich repeat	534..558	CDD:275380	4/23 (17%)
		LRR_4	535..574	CDD:289563	10/41 (24%)
		LRR_8	557..617	CDD:290566	18/74 (24%)
		LRR 13	558..579		7/27 (26%)
		leucine-rich repeat	559..582	CDD:275380	8/29 (28%)
		LRR 14	582..603		5/26 (19%)
		leucine-rich repeat	583..606	CDD:275380	5/28 (18%)
		LRR_8	605..665	CDD:290566	20/63 (32%)
		LRR 15	606..627		7/22 (32%)
		leucine-rich repeat	607..630	CDD:275380	7/24 (29%)
		LRR 16	630..651		7/22 (32%)
		leucine-rich repeat	631..654	CDD:275380	9/24 (38%)
		leucine-rich repeat	655..745	CDD:275380	18/89 (20%)
		LRRCT	663..711	CDD:214507	6/47 (13%)
		LRRNT	725..756	CDD:214470	6/30 (20%)
		LRR_RI	<741..869	CDD:238064	24/141 (17%)
		leucine-rich repeat	746..776	CDD:275380	7/38 (18%)
		LRR 17	753..774		7/29 (24%)
		LRR_8	775..835	CDD:290566	13/85 (15%)
		LRR 18	776..797		3/20 (15%)
		leucine-rich repeat	777..800	CDD:275380	3/22 (14%)
		LRR 19	800..821		4/35 (11%)
		leucine-rich repeat	801..824	CDD:275380	5/37 (14%)
		LRR 20	824..845		6/31 (19%)
		leucine-rich repeat	825..846	CDD:275380	5/31 (16%)
		LRRCT	857..906	CDD:214507
		EGF_CA	956..994	CDD:238011
		EGF_CA	998..1031	CDD:238011
		EGF_CA	1035..1072	CDD:238011
		EGF_CA	1074..1110	CDD:238011
		EGF	1123..1153	CDD:278437
		Laminin_G_2	1188..1314	CDD:280389
		EGF_CA	1370..1402	CDD:238011
		GHB_like	1463..1519	CDD:304424
		LRRNT	33..60	CDD:279764
		LRR_RI	<49..220	CDD:238064
		LRR_8	61..121	CDD:290566
		LRR 1	62..83
		leucine-rich repeat	64..86	CDD:275380
		LRR 2	86..107
		leucine-rich repeat	87..110	CDD:275380
		LRR_8	109..169	CDD:290566
		LRR 3	110..131
		leucine-rich repeat	111..134	CDD:275380
		LRR 4	134..155
		leucine-rich repeat	135..158	CDD:275380
		LRR_8	157..217	CDD:290566
		LRR 5	158..179
		leucine-rich repeat	159..182	CDD:275380
		LRR 6	182..203
leucine-rich repeat	183..206	CDD:275380
leucine-rich repeat	207..309	CDD:275380	14/59 (24%)
LRRNT	280..311	CDD:214470	13/60 (22%)
LRR_RI	<295..457	CDD:238064	47/187 (25%)
LRR 7	308..329		5/20 (25%)
LRR_8	311..367	CDD:290566	16/55 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910