DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and slit2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_021331524.1	Gene:	slit2 / 80353	ZFINID:	ZDB-GENE-010306-3	Length:	1551	Species:	Danio rerio

Alignment Length:	481	Identity:	108/481 - (22%)
Similarity:	171/481 - (35%)	Gaps:	131/481 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVL 78
            |.:|...||..|:.    .||.    ||| ..|.|   || .:.||..::|..:|:::...::.|
Zfish     1 MFVLKSVVLCALLC----GAGA----QSCPSQCSC---SG-TAVDCHGQSLRSVPRNIPRNVERL 53

  Fly    79 DFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTF 143
            |...|.:.::.:.:|  |||.|:..:.|....|..:.|.||:.|..|..|.|:.|.::.|....|
Zfish    54 DLNANNLTKITKADF--AGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQVLPELLF 116

  Fly   144 AGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLS 208
            .|..||..:.::.|:|:.:|...|...:.:..::...|::..::...|.....|..::|..|.:|
Zfish   117 LGTTKLFRLDLSENQIQGIPRKAFRGSTEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIS 181

  Fly   209 HLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKR----LYTPPTDCQEPPQLRGKLWSE 269
            .|...:|..:.||....|..|...|.|.:....|: :.:|    ||   |.|..||.|||...:|
Zfish   182 RLSVASFNHMPKLRTFRLHSNNLLCDCNVAWLSDW-LRQRPRLGLY---TQCMAPPSLRGHNIAE 242

  Fly   270 VPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQ 334
            |..:.|.|        ..|.|.                                |:.....||.|
Zfish   243 VQKKEFMC--------TDFSEG--------------------------------PQSHSSCSVLQ 267

  Fly   335 MPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIG 399
            .||                       .|...|                     :..|..|.|...
Zfish   268 CPE-----------------------LCTCSN---------------------NVVDCRGKGLTE 288

  Fly   400 APTIDPQTNMFLIICLIITTLLL------LLLVAVLTLFWYCRRIKTYQKDTTMMSGD---GLIS 455
            .||..|:|         ||.:.|      ::.......:...|||.......|.::.|   ||
Zfish   289 IPTNLPET---------ITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGL-- 342

  Fly   456 SKMDKTHNGSMLEGSVIMEMQKSLLN 481
                ::.|..:|.|:.|.|:.|.|.:
Zfish   343 ----RSLNSLVLYGNKITELPKGLFD 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	24/83 (29%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		LRR_8	99..159	CDD:290566	17/59 (29%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	11/58 (19%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..196	CDD:275380	2/22 (9%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	17/51 (33%)
		Ig	296..376	CDD:143165	8/79 (10%)
slit2	XP_021331524.1	LRRNT	21..51	CDD:214470	9/33 (27%)
		leucine-rich repeat	32..49	CDD:275380	4/16 (25%)
		LRR_8	48..108	CDD:316378	18/61 (30%)
		leucine-rich repeat	50..73	CDD:275380	7/24 (29%)
		leucine-rich repeat	74..97	CDD:275380	6/22 (27%)
		LRR_8	97..156	CDD:316378	14/58 (24%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		leucine-rich repeat	122..145	CDD:275380	5/22 (23%)
		LRR_8	144..204	CDD:316378	12/59 (20%)
		leucine-rich repeat	146..169	CDD:275380	2/22 (9%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		PCC	175..>237	CDD:188093	20/65 (31%)
		leucine-rich repeat	194..320	CDD:275380	40/222 (18%)
		LRRNT	267..299	CDD:214470	13/84 (15%)
		LRR_8	298..355	CDD:316378	12/62 (19%)
		leucine-rich repeat	321..344	CDD:275380	7/28 (25%)
		leucine-rich repeat	345..365	CDD:275380	7/20 (35%)
		LRR_8	375..427	CDD:316378
		leucine-rich repeat	393..416	CDD:275380
		PCC	398..>461	CDD:188093
		LRRNT	507..537	CDD:214470
		leucine-rich repeat	517..535	CDD:275380
		leucine-rich repeat	539..561	CDD:275380
		LRR_8	560..620	CDD:316378
		leucine-rich repeat	562..585	CDD:275380
		leucine-rich repeat	586..609	CDD:275380
		LRR_8	609..668	CDD:316378
		leucine-rich repeat	610..633	CDD:275380
		leucine-rich repeat	634..657	CDD:275380
		PCC	639..>716	CDD:188093
		leucine-rich repeat	658..780	CDD:275380
		leucine-rich repeat	677..728	CDD:275380
		NEL	<698..>863	CDD:330839
		leucine-rich repeat	736..757	CDD:275380
		LRR_8	780..839	CDD:316378
		leucine-rich repeat	781..804	CDD:275380
		leucine-rich repeat	805..828	CDD:275380
		leucine-rich repeat	829..850	CDD:275380
		PCC	834..>1026	CDD:188093
		EGF	1015..1042	CDD:306513
		EGF_CA	1060..1096	CDD:238011
		EGF_CA	1098..1134	CDD:238011
		Laminin_G_2	1210..1338	CDD:308045
		GHB_like	1489..1550	CDD:328788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910