DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and LRFN3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_078785.1	Gene:	LRFN3 / 79414	HGNCID:	28370	Length:	628	Species:	Homo sapiens

Alignment Length:	407	Identity:	111/407 - (27%)
Similarity:	164/407 - (40%)	Gaps:	64/407 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGMILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQ 76
            :.::.|||.:|.:..|..||.:.|.   ..| ..|.||..|...|..|....|..:|..:.....
Human     1 MAILPLLLCLLPLAPASSPPQSATP---SPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAA 62

  Fly    77 VLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPG 141
            .|..|.|.|..:||.:  ||.:..:..:.|...||:.|...||..|..|..|.|.|||:..|..|
Human    63 ELRLADNFIASVRRRD--LANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEG 125

  Fly   142 TFAGLEKLRNVIINNNE-------------------------IEVLPNHLFVNLSFLSRIEFRNN 181
            ...||..||::|::||:                         :|.||......|..::.:...:|
Human   126 QLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHN 190

  Fly   182 RLRQVQLHVFAGTMALSAISLEQNRLSHLHKE-TFKDLQKL----------MHLSLQGNAWNCSC 235
            .|..|....|:....|:.:.:..|||:.:..: .|..|..|          :.|:..||..:|:|
Human   191 LLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNC 255

  Fly   236 ELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRS---FIEANHDNIS 297
            ||...|..|....|..    |..||.|.|:.:..|..|.|.|.|.:: :.||   .:.|... .:
Human   256 ELVWLRRLAREDDLEA----CASPPALGGRYFWAVGEEEFVCEPPVV-THRSPPLAVPAGRP-AA 314

  Fly   298 LPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTC 362
            |.||.||.|.|.|.||         .|:.|:|.:..:....|:    ..|.::.....|.|.:||
Human   315 LRCRAVGDPEPRVRWV---------SPQGRLLGNSSRARAFPN----GTLELLVTEPGDGGIFTC 366

  Fly   363 VADNRGGRAEAEFQLLV 379
            :|.|..|.|.|..:|.|
Human   367 IAANAAGEATAAVELTV 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/108 (28%)
		leucine-rich repeat	76..100	CDD:275380	8/23 (35%)
		LRR_8	99..159	CDD:290566	22/84 (26%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	15/83 (18%)
		leucine-rich repeat	149..172	CDD:275380	9/47 (19%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	8/42 (19%)
		leucine-rich repeat	197..220	CDD:275380	6/23 (26%)
		LRRCT	229..277	CDD:214507	16/47 (34%)
		Ig	296..376	CDD:143165	24/79 (30%)
LRFN3	NP_078785.1	LRR_8	59..119	CDD:290566	20/61 (33%)
		LRR 1	60..83		8/24 (33%)
		LRR_RI	<63..168	CDD:238064	30/106 (28%)
		leucine-rich repeat	63..84	CDD:275380	8/22 (36%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		8/20 (40%)
		leucine-rich repeat	109..132	CDD:275380	10/22 (45%)
		LRR 4	132..153		5/20 (25%)
		leucine-rich repeat	133..157	CDD:275380	5/23 (22%)
		LRR_8	157..216	CDD:290566	10/58 (17%)
		LRR 5	157..178		3/20 (15%)
		leucine-rich repeat	158..181	CDD:275380	4/22 (18%)
		LRR 6	181..202		4/20 (20%)
		leucine-rich repeat	182..205	CDD:275380	4/22 (18%)
		LRR 7	205..226		4/20 (20%)
		leucine-rich repeat	206..230	CDD:275380	6/23 (26%)
		leucine-rich repeat	242..253	CDD:275378	3/10 (30%)
		TPKR_C2	249..>281	CDD:301599	12/35 (34%)
		IG_like	302..383	CDD:214653	27/94 (29%)
		Ig	310..383	CDD:299845	25/86 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..430		1/2 (50%)
		fn3	424..502	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910