DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and PXDN

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens

Alignment Length:	1063	Identity:	213/1063 - (20%)
Similarity:	354/1063 - (33%)	Gaps:	310/1063 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MGNRTERSGRRLGMILLLL---GVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNK 62
            |..|:...|||..:.|:|.   |.|.|:  ...|.||       | ..|.|    .:.:..|.:.
Human     1 MAKRSRGPGRRCLLALVLFCAWGTLAVV--AQKPGAG-------CPSRCLC----FRTTVRCMHL 52

  Fly    63 ALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIE 127
            .|..:|. ::.:..:||...|:                          |:|:...||:.|..|..
Human    53 LLEAVPA-VAPQTSILDLRFNR--------------------------IREIQPGAFRRLRNLNT 90

  Fly   128 LDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFA 192
            |.|:.|:|:.:..|.|..||.|:.:.:..|||:.:....|..|:.|.::....|::..:....|.
Human    91 LLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQ 155

  Fly   193 GTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD-- 255
            ....|..:.|..||::||...||..|:.:..|.|..|..:|.||:....|..   :.|....:
Human   156 HLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLL---KTYAESGNAQ 217

  Fly   256 ----CQEPPQLRGKLWSEVPSENFAC-RPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYN 315
                |:.|.:::|:..:.:..|...| ||||....:.....:.:.:...||..|:|:|.:.|:.|
Human   218 AAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRN 282

  Fly   316 KRPL-QQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLV 379
            ...| .:.|.|:.:|..             ..|.|...:.:|:|.|.|:|.|..|..:.:...|
Human   283 NNELSMKTDSRLNLLDD-------------GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTL- 333

  Fly   380 SGDYAGAVSASDGMGMGAIGAPT--IDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCR------ 436
                         ...|:...||  |.||...             :|:...:||  .|.
Human   334 -------------RYFGSPARPTFVIQPQNTE-------------VLVGESVTL--ECSATGHPP 370

  Fly   437 -RIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIM----EMQKSLLNEVNPVE--------- 487
             ||...:.|.|.:.    :..:::.|.:|.:...:|:.    |...|..|.::.|.
Human   371 PRISWTRGDRTPLP----VDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQA 431

  Fly   488 ------KPPRRTDIE--SVD-----------------GGDDVLEIKKTLL--DDTVY---VANHS 522
                  .|..|..||  :||                 ||..:...::.|:  ..|:.   ||.|.
Human   432 LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHD 496

  Fly   523 RDE---EAVSV-----AMSDTTTTPRSRHTYVDDAYANSLPPD-LLAFPARVPPTSPSMQSSQSN 578
            :.:   :||::     .::..|..||     |...:| |:|.| .:...|.|     .:..|...
Human   497 QGQYECQAVNIIGSQKVVAHLTVQPR-----VTPVFA-SIPSDTTVEVGANV-----QLPCSSQG 550

  Fly   579 IPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTM-----------------TAPHNGFMTLQHPK 626
            .|:..|...:....:|.....|::|.|......:                 :|..:..:::..|.
Human   551 EPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPD 615

  Fly   627 -SRN---------LALIATT----NSSRQH-------------------QHHHQLQQQQQHHHHH 658
             |||         :..|||.    ||:|.|                   :..:.::|.:......
Human   616 VSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFE 680

  Fly   659 QQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRAPSWAPSTSGAAGHGSI- 722
            :..|..|:..||.|..            ...|.......:.   .|:..:...:.||...|..:
Human   681 RTLQLIQEHVQHGLMV------------DLNGTSYHYNDLV---SPQYLNLIANLSGCTAHRRVN 730

  Fly   723 --------QLSEFQSPTSPN---PSETGTATTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQ 776
                    |.......|..|   |....:.|..|...:.||:| |..|..|.|
Human   731 NCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYEN-GFNTPRGIN------------ 782

  Fly   777 GGAGQQYSMRDRPLPATPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQQQQQQRLGSMDTEPL 841
              ..:.|:....|:|...|.|.:.:.| .:...:..|.|:|..|.|..          .:|:
Human   783 --PHRLYNGHALPMPRLVSTTLIGTET-VTPDEQFTHMLMQWGQFLDH----------DLDS--- 831

  Fly   842 YGVRQQGITILPGSSISGAGLGHAAYLSPGSGAAVSPSHASS--SGDSP-KAAKIPPRPPPKPKK 903
                    |::..|.         |..|.|       .|.|:  |.|.| .:..|||........
Human   832 --------TVVALSQ---------ARFSDG-------QHCSNVCSNDPPCFSVMIPPNDSRARSG 872

  Fly   904 KMSVTTTRS----GQGSTSQLFD 922
            ...:...||    |.|.||.|.:
Human   873 ARCMFFVRSSPVCGSGMTSLLMN 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	20/83 (24%)
		leucine-rich repeat	76..100	CDD:275380	3/23 (13%)
		LRR_8	99..159	CDD:290566	16/59 (27%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		LRRCT	229..277	CDD:214507	10/53 (19%)
		Ig	296..376	CDD:143165	20/80 (25%)
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380	3/18 (17%)
		leucine-rich repeat	66..87	CDD:275380	8/46 (17%)
		LRR 1	87..108		7/20 (35%)
		LRR_4	110..151	CDD:289563	9/40 (23%)
		LRR_8	111..170	CDD:290566	12/58 (21%)
		LRR 2	111..132		5/20 (25%)
		leucine-rich repeat	112..135	CDD:275378	6/22 (27%)
		LRR_4	135..175	CDD:289563	9/39 (23%)
		LRR 3	135..156		3/20 (15%)
		leucine-rich repeat	136..159	CDD:275378	3/22 (14%)
		LRR_8	158..>195	CDD:290566	12/36 (33%)
		LRR 4	159..180		8/20 (40%)
		leucine-rich repeat	160..183	CDD:275378	9/22 (41%)
		leucine-rich repeat	184..196	CDD:275378	3/11 (27%)
		TPKR_C2	192..243	CDD:301599	10/53 (19%)
		Ig	246..333	CDD:299845	23/99 (23%)
		I-set	246..333	CDD:254352	23/99 (23%)
		I-set	342..429	CDD:254352	20/105 (19%)
		Ig	346..429	CDD:299845	18/101 (18%)
		I-set	433..519	CDD:254352	15/85 (18%)
		Ig3_Peroxidasin	446..519	CDD:143222	12/72 (17%)
		I-set	525..611	CDD:254352	14/91 (15%)
		Ig4_Peroxidasin	542..610	CDD:143223	9/72 (13%)
		An_peroxidase	741..1282	CDD:281139	44/208 (21%)
		peroxidasin_like	864..1303	CDD:188658	8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380
		VWC	1415..1470	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910