DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek5 and slit3

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001072738.1 Gene:slit3 / 780195 XenbaseID:XB-GENE-991050 Length:1519 Species:Xenopus tropicalis


Alignment Length:678 Identity:150/678 - (22%)
Similarity:249/678 - (36%) Gaps:187/678 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 PPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFL 94
            ||:....  ..|| ..|.|..|    ..||:.|.||:||.::.          ..|.|:|.|:..
 Frog   266 PPSCNAN--AVSCPSACTCSNN----VVDCRGKGLTEIPANLP----------EGIIEIRLEQNS 314

  Fly    95 LAGLP--------NVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRN 151
            :..:|        .:.:|.:....|.|:..:||.||..|..|.|.||:|.|:..|.|.||..|:.
 Frog   315 IKAIPAGVFTPYKKLKRIDISKNQISEIAADAFSGLKSLTSLVLYGNKITEIPKGLFDGLVSLQL 379

  Fly   152 VIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFK 216
            :::|.|:|..|                        :::.|.....|:.:||..|:|..:.|..|.
 Frog   380 LLLNANKINCL------------------------RVNTFQDLQNLNLLSLYDNKLQTISKGLFA 420

  Fly   217 DLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFAC---- 277
            .||.:..|.|..|.:.|.|.|:...|:.....:.|....|..|.:|..|..|::.|:.|.|    
 Frog   421 PLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCTSPRRLANKRISQIKSKKFRCTGSE 485

  Fly   278 --RPRILGSV-------------RSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVR 327
              |.:..|..             .:.::.::..||.    :.|..|..|     ..|:..|..:.
 Frog   486 DYRSKFSGDCFMDLVCPEKCRCEGTIVDCSNQKISR----IPSYLPEYT-----SDLRLNDNEIT 541

  Fly   328 VLTSVEQMPEQPS--QVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSAS 390
            ||.:.....:.|:  ::..|..:|..:|   :||:    |...|..|    |:::|:...:|...
 Frog   542 VLEATGIFKKLPNLRKINLSNNKIKDIR---EGAF----DGAAGVQE----LMLTGNQLESVHGR 595

  Fly   391 DGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSG--DGL 453
              |..|.:|..|:..::|  |:.|:...|...|..|.:|:|  |..||      ||:..|  :.|
 Frog   596 --MFRGLVGLKTLMLRSN--LMSCINNDTFTGLSSVRLLSL--YDNRI------TTITPGAFNTL 648

  Fly   454 IS-SKMDKTHN-----------GSMLEGSVIMEMQKSLLNEVNP-VEKP--PRRTDIESV----- 498
            :| |.::...|           |..|        :|..:...|| .:||  .:...|:.|     
 Frog   649 VSLSTINLLSNPFNCNCHLAWLGKWL--------RKKRVVSGNPRCQKPYFLKEIPIQDVAIQDF 705

  Fly   499 --DGGDDVLEIKKTLLDDTVYVANHSRD-----EEAVSVAMSDTTTTPRS-----RHTYVDDAYA 551
              ||.:          :.:...|:|..:     |..|........|.|::     ...|::..:.
 Frog   706 TCDGNE----------ESSCLPASHCPEQCTCVESVVRCGNQGLRTLPKNIPKDVTELYLEGNHL 760

  Fly   552 NSLPPDLLAFP----ARVPPTSPSMQSSQ--SN----------------IPDQVIYGIRSPPSLT 594
            .|:|.::.:|.    ..:...|.|:.|:.  ||                ||.....|::|...||
 Frog   761 TSVPKEISSFKHLTLIDLSNNSISVLSNYTFSNVTQLSTLILSYNRLRCIPVHAFNGLKSLRVLT 825

  Fly   595 SPVYTHMTPHGIYGTKTMTAPHNGFMTL 622
                       ::|....|.|...|..|
 Frog   826 -----------LHGNDISTVPDGSFSDL 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 26/91 (29%)
leucine-rich repeat 76..100 CDD:275380 5/31 (16%)
LRR_8 99..159 CDD:290566 22/67 (33%)
leucine-rich repeat 101..124 CDD:275380 7/22 (32%)
LRR 122..145 CDD:197688 10/22 (45%)
leucine-rich repeat 125..148 CDD:275380 11/22 (50%)
LRR_8 148..207 CDD:290566 10/58 (17%)
leucine-rich repeat 149..172 CDD:275380 5/22 (23%)
leucine-rich repeat 173..196 CDD:275380 1/22 (5%)
LRR_8 197..>229 CDD:290566 11/31 (35%)
leucine-rich repeat 197..220 CDD:275380 8/22 (36%)
LRRCT 229..277 CDD:214507 13/47 (28%)
Ig 296..376 CDD:143165 18/81 (22%)
slit3NP_001072738.1 LRRNT 29..60 CDD:214470
LRR_8 57..117 CDD:290566
LRR_4 60..97 CDD:289563
leucine-rich repeat 60..82 CDD:275380
LRR_RI <83..216 CDD:238064
leucine-rich repeat 83..106 CDD:275380
LRR_8 105..165 CDD:290566
leucine-rich repeat 107..130 CDD:275380
leucine-rich repeat 131..154 CDD:275380
LRR_8 155..213 CDD:290566
leucine-rich repeat 155..178 CDD:275380
leucine-rich repeat 179..202 CDD:275380
leucine-rich repeat 203..305 CDD:275380 14/54 (26%)
TPKR_C2 211..260 CDD:301599
LRRNT 276..307 CDD:214470 12/44 (27%)
LRR_8 307..363 CDD:290566 16/55 (29%)
leucine-rich repeat 307..328 CDD:275380 4/20 (20%)
LRR_4 327..367 CDD:289563 14/39 (36%)
leucine-rich repeat 329..352 CDD:275380 7/22 (32%)
LRR_8 351..435 CDD:290566 29/107 (27%)
leucine-rich repeat 353..373 CDD:275380 9/19 (47%)
leucine-rich repeat 377..400 CDD:275380 6/46 (13%)
leucine-rich repeat 401..422 CDD:275380 7/20 (35%)
leucine-rich repeat 425..516 CDD:275380 18/90 (20%)
TPKR_C2 433..>463 CDD:301599 7/29 (24%)
LRRNT 501..531 CDD:214470 5/38 (13%)
LRR_4 533..570 CDD:289563 8/39 (21%)
leucine-rich repeat 533..554 CDD:275380 4/20 (20%)
LRR_8 553..613 CDD:290566 17/74 (23%)
leucine-rich repeat 555..578 CDD:275380 6/29 (21%)
leucine-rich repeat 579..602 CDD:275380 6/28 (21%)
LRR_8 602..661 CDD:290566 20/68 (29%)
leucine-rich repeat 603..626 CDD:275380 6/24 (25%)
leucine-rich repeat 627..650 CDD:275380 10/30 (33%)
leucine-rich repeat 651..741 CDD:275380 17/107 (16%)
LRRCT 659..708 CDD:214507 10/56 (18%)
LRRNT 720..752 CDD:214470 5/31 (16%)
leucine-rich repeat 742..772 CDD:275380 5/29 (17%)
LRR_8 771..831 CDD:290566 12/70 (17%)
leucine-rich repeat 773..796 CDD:275380 5/22 (23%)
LRR_4 795..836 CDD:289563 8/51 (16%)
leucine-rich repeat 797..820 CDD:275380 3/22 (14%)
leucine-rich repeat 821..842 CDD:275380 6/31 (19%)
LRRCT 853..902 CDD:214507
EGF 916..947 CDD:278437
EGF_CA 952..989 CDD:238011
EGF_CA 994..1027 CDD:238011
EGF_CA 1031..1068 CDD:238011
EGF_CA 1070..1106 CDD:238011
LamG 1155..1308 CDD:238058
GHB_like 1454..1517 CDD:304424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.