DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and TLR1

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens


Alignment Length:253 Identity:55/253 - (21%)
Similarity:102/253 - (40%) Gaps:42/253 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 CKNKALTKIPQDMSN---------------EMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRN 108
            |.:|....:..|.||               |::.|....||:.||.:...:...:.::.::   :
Human   343 CPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQL---D 404

  Fly   109 CTIQEVHREAFKG----LHILIELDLSGNRI-----RELHPGTFAGLEKLRNVIINNNEIEVLPN 164
            .:...|..:..||    ...|:.|::|.|.:     |.|.|       :::.:.:::|:|:.:|.
Human   405 ISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPP-------RIKVLDLHSNKIKSIPK 462

  Fly   165 HLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGN 229
            .: |.|..|..:....|.|  ..|.......:||.:.::.|.:||...:.|:..||:..:....|
Human   463 QV-VKLEALQELNVAFNSL--TDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDN 524

  Fly   230 AWNCSCELQDF---RDFAISKRLYTPPTD--CQEPPQLRGKLWSEVPSENFACRPRIL 282
            .:.|:|||.:|   .|...|:.|...|..  |..|...||.|..:......:|...:|
Human   525 PFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLL 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 16/92 (17%)
leucine-rich repeat 76..100 CDD:275380 5/23 (22%)
LRR_8 99..159 CDD:290566 11/68 (16%)
leucine-rich repeat 101..124 CDD:275380 3/26 (12%)
LRR 122..145 CDD:197688 7/27 (26%)
leucine-rich repeat 125..148 CDD:275380 7/27 (26%)
LRR_8 148..207 CDD:290566 12/58 (21%)
leucine-rich repeat 149..172 CDD:275380 5/22 (23%)
leucine-rich repeat 173..196 CDD:275380 4/22 (18%)
LRR_8 197..>229 CDD:290566 8/31 (26%)
leucine-rich repeat 197..220 CDD:275380 6/22 (27%)
LRRCT 229..277 CDD:214507 15/52 (29%)
Ig 296..376 CDD:143165
TLR1NP_003254.2 leucine-rich repeat 47..70 CDD:275378
LRR 1 54..77
LRR_8 69..124 CDD:316378
leucine-rich repeat 71..94 CDD:275378
LRR 2 78..101
leucine-rich repeat 95..115 CDD:275378
LRR 3 102..125
leucine-rich repeat 116..140 CDD:275378
LRR 4 126..150
leucine-rich repeat 141..152 CDD:275378
LRR 5 151..175
LRR 6 176..199
LRR 7 200..223
LRR 8 224..250
LRR 9 251..278
LRR 10 279..308
LRR 11 309..337
Interaction with bacterial lipopeptide 313..316
LRR 12 338..361 5/17 (29%)
PLN00113 <352..>560 CDD:331614 47/220 (21%)
leucine-rich repeat 352..373 CDD:275380 3/20 (15%)
LRR 13 362..388 5/25 (20%)
leucine-rich repeat 374..399 CDD:275380 5/24 (21%)
LRR 14 389..414 1/27 (4%)
leucine-rich repeat 400..424 CDD:275380 3/26 (12%)
LRR 15 415..437 6/21 (29%)
leucine-rich repeat 425..446 CDD:275380 7/27 (26%)
LRR 16 438..457 4/25 (16%)
leucine-rich repeat 447..469 CDD:275380 5/22 (23%)
LRR 17 458..478 4/20 (20%)
leucine-rich repeat 470..492 CDD:275380 4/23 (17%)
LRR 18 479..500 4/22 (18%)
leucine-rich repeat 494..515 CDD:275380 4/20 (20%)
LRR 19 501..524 5/22 (23%)
LRRCT 553..577 CDD:279765 5/23 (22%)
TIR 636..779 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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