DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek5 and Lingo3

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001103079.1 Gene:Lingo3 / 690755 RGDID:1592209 Length:589 Species:Rattus norvegicus


Alignment Length:576 Identity:122/576 - (21%)
Similarity:193/576 - (33%) Gaps:185/576 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFA 81
            |.:||:.::|:...|...|       | ...|:.::..::..|..:.||.:|:.:..|.::|:.:
  Rat     5 LHMLGLHLLLLPTAPLATG-------C-PARCECSASTRTVACGRRRLTAVPEGIPAETRMLELS 61

  Fly    82 HNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGL 146
            .|:|..|...:  ||.||.:.::.|.:..|..|...||..|..|..|.|.||:::.:.||.|..|
  Rat    62 RNRIRCLNPGD--LASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHL 124

  Fly   147 EKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQ------- 204
            :.|..:.::.|::.:|.:..|.:|..|.|:|..:|.|..:....|||.:.|:.::||:       
  Rat   125 DSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLS 189

  Fly   205 ----------------------------------------------------------------- 204
                                                                             
  Rat   190 PESLGHLRGLGALRLRHLAIAALEDQNFQKLPGLLHLEIDNWPLLEEVAPGSLRGLNLTSLSITH 254

  Fly   205 ----------------------------------------------------------------- 204
                                                                             
  Rat   255 TNITAVPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQI 319

  Fly   205 -------NRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD-----CQ 257
                   |.||.|.:.||..:..|..|.:.||...|.|.|     ..|.:|..|...|     |.
  Rat   320 RLLNLSDNLLSTLEENTFHSVNTLETLRVDGNPLACDCRL-----LWIVQRRKTLNFDGRLPACA 379

  Fly   258 EPPQLRGKLWSEVPS----ENFACR-PRILGSVRSFIEANH-DNISLPCRIVGSPRPNVTWVYNK 316
            .|.::||.....:|.    |.|.|| |:|.......:.|.. |::...||..|.|.|.|.||   
  Rat   380 TPAEVRGDALHNLPDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWV--- 441

  Fly   317 RPLQQYDPRVRVLTSVEQMPEQPSQVLT-SELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVS 380
                  .|:...:|:..:   ..::||. ..|.|...|..|.|.|||||.|.||. :..|..|..
  Rat   442 ------TPQHHSVTAASR---GRARVLPGGTLAITDTRPQDSGTYTCVASNAGGN-DTYFATLTI 496

  Fly   381 GDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCR 436
            ...|.. :.|||.....:|.......|.:.:...:...|.|.::|...|.||.:.|
  Rat   497 HPAANR-TQSDGHNETQVGVRFPLDLTTILVSTAMGCITFLGVVLFCFLLLFVWSR 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 25/83 (30%)
leucine-rich repeat 76..100 CDD:275380 7/23 (30%)
LRR_8 99..159 CDD:290566 18/59 (31%)
leucine-rich repeat 101..124 CDD:275380 6/22 (27%)
LRR 122..145 CDD:197688 9/22 (41%)
leucine-rich repeat 125..148 CDD:275380 9/22 (41%)
LRR_8 148..207 CDD:290566 17/202 (8%)
leucine-rich repeat 149..172 CDD:275380 5/22 (23%)
leucine-rich repeat 173..196 CDD:275380 8/22 (36%)
LRR_8 197..>229 CDD:290566 11/175 (6%)
leucine-rich repeat 197..220 CDD:275380 9/166 (5%)
LRRCT 229..277 CDD:214507 15/56 (27%)
Ig 296..376 CDD:143165 25/80 (31%)
Lingo3NP_001103079.1 LRRNT 23..55 CDD:214470 7/39 (18%)
leucine-rich repeat 34..53 CDD:275380 4/18 (22%)
LRR <55..353 CDD:227223 49/299 (16%)
leucine-rich repeat 55..78 CDD:275380 7/24 (29%)
leucine-rich repeat 79..102 CDD:275380 6/22 (27%)
leucine-rich repeat 103..150 CDD:275380 14/46 (30%)
leucine-rich repeat 151..174 CDD:275380 8/22 (36%)
leucine-rich repeat 175..198 CDD:275380 3/22 (14%)
leucine-rich repeat 199..222 CDD:275380 0/22 (0%)
leucine-rich repeat 223..246 CDD:275380 0/22 (0%)
LRR_8 246..302 CDD:404697 0/55 (0%)
leucine-rich repeat 247..270 CDD:275380 0/22 (0%)
leucine-rich repeat 271..292 CDD:275380 0/20 (0%)
leucine-rich repeat 295..316 CDD:275380 0/20 (0%)
leucine-rich repeat 319..342 CDD:275380 6/22 (27%)
PCC 331..>405 CDD:188093 22/78 (28%)
Ig 407..489 CDD:416386 28/94 (30%)
Ig strand A' 413..417 CDD:409353 0/3 (0%)
Ig strand B 423..432 CDD:409353 2/8 (25%)
Ig strand C 437..442 CDD:409353 3/13 (23%)
Ig strand C' 445..447 CDD:409353 0/1 (0%)
Ig strand D 456..459 CDD:409353 0/2 (0%)
Ig strand E 462..469 CDD:409353 2/6 (33%)
Ig strand F 475..483 CDD:409353 6/7 (86%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46071
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.