DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Rtn4r

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_075358.1	Gene:	Rtn4r / 65079	MGIID:	2136886	Length:	473	Species:	Mus musculus

Alignment Length:	495	Identity:	112/495 - (22%)
Similarity:	173/495 - (34%)	Gaps:	145/495 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WMQS------C-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLA 96
            |:|:      | |.|.| :|..|.:..|..:.|..:|..:....|.:....|:|..:....|  .
Mouse    17 WLQAWRVATPCPGACVC-YNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISHVPAASF--Q 78

  Fly    97 GLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNR-------------------------IR 136
            ...|:..::|.:..:..:...||.||.:|.:||||.|.                         :|
Mouse    79 SCRNLTILWLHSNALARIDAAAFTGLTLLEQLDLSDNAQLHVVDPTTFHGLGHLHTLHLDRCGLR 143

  Fly   137 ELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAIS 201
            ||.||.|.||..|:.:.:.:|.::.||::.|.:|..|:.:....||:..|..|.|.|..:|..:.
Mouse   144 ELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLL 208

  Fly   202 LEQNRLSHLHKETFKDLQKLM------------------------HLSLQGNAWNCSCE------ 236
            |.||.::.:|...|:||.:||                        :|.|..|.|.|.|.
Mouse   209 LHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLMPLRSLQYLRLNDNPWVCDCRARPLWA 273

  Fly   237 -LQDFRDFAISKRLYTPPTDCQEPPQLRGK-LWSEVPSENFAC-------RPRILGSVRSFIEAN 292
             ||.||.       .:....|..|.:|..: |.....|:...|       ||     :::....:
Mouse   274 WLQKFRG-------SSSEVPCNLPQRLADRDLKRLAASDLEGCAVASGPFRP-----IQTSQLTD 326

  Fly   293 HDNISLP--CR---------------------IVGSPRPNVTWVYN-KRPLQQYDPRVRVLTSVE 333
            .:.:|||  |:                     :.|...|..|...| ..|....|.....|.|..
Mouse   327 EELLSLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPSSA 391

  Fly   334 QMP---------EQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSA 389
            :.|         |.|....|...|..|          |   :|..|..:..:|..:|  :||...
Mouse   392 EPPLTALRPGGSEPPGLPTTGPRRRPG----------C---SRKNRTRSHCRLGQAG--SGASGT 441

  Fly   390 SDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVL 429
            .|..|.||:.|           :.|.:....|.|:|..||
Mouse   442 GDAEGSGALPA-----------LACSLAPLGLALVLWTVL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	26/108 (24%)
		leucine-rich repeat	76..100	CDD:275380	4/23 (17%)
		LRR_8	99..159	CDD:290566	22/84 (26%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	13/47 (28%)
		leucine-rich repeat	125..148	CDD:275380	14/47 (30%)
		LRR_8	148..207	CDD:290566	17/58 (29%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	197..>229	CDD:290566	12/55 (22%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	13/55 (24%)
		Ig	296..376	CDD:143165	21/112 (19%)
Rtn4r	NP_075358.1	LRR 1	58..79		4/22 (18%)
		LRR_8	60..115	CDD:290566	15/56 (27%)
		leucine-rich repeat	60..82	CDD:275380	4/23 (17%)
		LRR 2	82..103		4/20 (20%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		LRR_RI	<90..>166	CDD:238064	20/75 (27%)
		LRR 3	106..128		6/21 (29%)
		leucine-rich repeat	107..131	CDD:275380	6/23 (26%)
		LRR_8	131..190	CDD:290566	16/58 (28%)
		LRR 4	131..152		6/20 (30%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR 5	155..176		5/20 (25%)
		LRR_4	156..195	CDD:289563	10/38 (26%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		LRR_8	179..238	CDD:290566	17/58 (29%)
		LRR 6	179..200		6/20 (30%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		LRR 7	203..224		6/20 (30%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR 8	227..248		2/20 (10%)
		leucine-rich repeat	228..251	CDD:275380	2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..446		22/114 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910