DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and LINGO3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001094861.1	Gene:	LINGO3 / 645191	HGNCID:	21206	Length:	592	Species:	Homo sapiens

Alignment Length:	571	Identity:	127/571 - (22%)
Similarity:	186/571 - (32%)	Gaps:	190/571 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIP 86
            |::|.|.|||..|       | ..|.|...:  ::..|..:.||.:|..:..|.::|:.:.|:|.
Human    12 LLLLPAAPPPAGG-------CPARCECTVQT--RAVACTRRRLTAVPDGIPAETRLLELSRNRIR 67

  Fly    87 ELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRN 151
            .|...:  ||.||.:.::.|....|..|...||..|..|..|.|.||:::.:.||.|..|:.|..
Human    68 CLNPGD--LAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTL 130

  Fly   152 VIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQ------------ 204
            :.::.|::.:|.::.|.:|..|.|:|..:|.|..|....|||.:||..::||:
Human   131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLG 195

  Fly   205 ----------------------------------------------------------------- 204

Human   196 HLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITA 260

  Fly   205 ----------------------------------------------------------------- 204

Human   261 VPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNL 325

  Fly   205 --NRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD-----CQEPPQL 262
              |.||.|.:.||..:..|..|.:.||...|.|.|     ..|.:|..|...|     |..|.::
Human   326 SNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL-----LWIVQRRKTLNFDGRLPACATPAEV 385

  Fly   263 RGKLWSEVPS----ENFACR-PRILGSVRSFIEAN-HDNISLPCRIVGSPRPNVTWVY-NKRPLQ 320
            ||.....:|.    |.|.|| |:|.......:.|. .:::...||..|.|.|.|.||. ..||:.
Human   386 RGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVT 450

  Fly   321 QYDP-RVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYA 384
            .... |.|||..             ..|.|...|..|.|.|||||.|.||.......|.|..:.|
Human   451 ATSAGRARVLPG-------------GTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPA 502

  Fly   385 GAVSASDGMG--MGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFW 433
            ...:..:...  :.|:.|| :|..|.:.......||.|.::|...||...|
Human   503 ANRTPGEAHNETLAALRAP-LDLTTILVSTAMGCITFLGVVLFCFVLLFVW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	19/202 (9%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..196	CDD:275380	9/22 (41%)
		LRR_8	197..>229	CDD:290566	11/175 (6%)
		leucine-rich repeat	197..220	CDD:275380	9/166 (5%)
		LRRCT	229..277	CDD:214507	15/56 (27%)
		Ig	296..376	CDD:143165	27/81 (33%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	9/42 (21%)
		LRR 1	55..76		6/22 (27%)
		LRR_8	57..138	CDD:290566	25/82 (30%)
		LRR_4	59..95	CDD:289563	11/37 (30%)
		leucine-rich repeat	59..79	CDD:275380	7/21 (33%)
		LRR 2	79..100		5/20 (25%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		LRR 3	103..124		8/20 (40%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_RI	111..>286	CDD:238064	24/174 (14%)
		LRR_8	127..>172	CDD:290566	12/44 (27%)
		LRR 4	127..148		4/20 (20%)
		leucine-rich repeat	128..151	CDD:275380	5/22 (23%)
		LRR 5	151..172		7/20 (35%)
		leucine-rich repeat	152..199	CDD:275380	13/46 (28%)
		LRR 6	175..196		4/20 (20%)
		LRR_8	198..258	CDD:290566	0/59 (0%)
		leucine-rich repeat	200..223	CDD:275380	0/22 (0%)
		LRR 7	207..228		0/20 (0%)
		leucine-rich repeat	224..247	CDD:275380	0/22 (0%)
		LRR_8	247..303	CDD:290566	0/55 (0%)
		LRR 8	247..268		0/20 (0%)
		leucine-rich repeat	248..271	CDD:275380	0/22 (0%)
		LRR 9	271..292		0/20 (0%)
		leucine-rich repeat	272..293	CDD:275380	0/20 (0%)
		LRR 10	295..316		0/20 (0%)
		leucine-rich repeat	296..319	CDD:275380	0/22 (0%)
		LRR 11	319..340		6/20 (30%)
		leucine-rich repeat	322..343	CDD:275380	6/20 (30%)
		I-set	407..497	CDD:254352	31/102 (30%)
		Ig	422..490	CDD:299845	27/80 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910