DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrrc4

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	137/679 - (20%)
Similarity:	229/679 - (33%)	Gaps:	216/679 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGMILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQ 76
            |.::.|...|.::..|:   .|..:...|:| ..|.|. |...|.. |..:.|:::||.:.:..:
  Rat    18 LPVVYLTAQVWILCAAI---AAAASAGPQNCPSVCSCS-NQFSKVV-CTRRGLSEVPQGIPSNTR 77

  Fly    77 VLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPG 141
            .|:...|.|..::.:.|  ..|.::..:.|....|:::...||.||..|..|:|..|.:..:..|
  Rat    78 YLNLMENNIQMIQADTF--RHLHHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSG 140

  Fly   142 TFAGLEKLRNVIINNNEIEVLP------------------------------------------- 163
            .|..|.|||.:.:.||.||.:|
  Rat   141 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMC 205

  Fly   164 ---------------------NHL-------FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAI 200
                                 ||.       |..||.|.::...|:::..::.:.|.|..:|..:
  Rat   206 NIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVEL 270

  Fly   201 SLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD-----CQEPP 260
            :|..|.||.|..:.|..|:.|:.|.|..|.|||.|   |....|...|.|.|...     |..|.
  Rat   271 NLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDC---DILWLAWWLREYIPTNSTCCGRCHAPM 332

  Fly   261 QLRGKLWSEVPSENFAC-RPRILGSVRSFIEANHDNIS-LPCRIVGSPRPNVTWVYNKRPLQQYD 323
            .:||:...||...:|.| .|.|:.:.|. :..:.|.:: |.||.  .|..:|.|:.
  Rat   333 HMRGRYLVEVDQASFQCSAPFIMDAPRD-LNISEDRMAELKCRT--PPMSSVKWLL--------- 385

  Fly   324 PRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSG------- 381
            |...||:...:.| :.|.:....|....|...|.|.|||:..|..|.:.|...|.||.
  Rat   386 PNGTVLSHASRHP-RISVLNDGTLNFSRVLLIDTGVYTCMVTNVAGNSNASAYLNVSSAELNTPN 449

  Fly   382 ---------------------DYAGAVSASDGMGMG----------------AIGAPTIDP---- 405
                                 .|....:.|.|....                .:..|:.|.
  Rat   450 FSFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPSTDTTDKM 514

  Fly   406 --------QTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDK-- 460
                    :|...:|.|.:..|   ||..|:|.:|:..|  |.:|:.:|:.:...:...::|:
  Rat   515 QTSLDEVMKTTKIIIGCFVAVT---LLAAAMLIVFYKLR--KRHQQRSTVTAARTVEIIQVDEDI 574

  Fly   461 ----------THNGSMLEGSVIME-------------------MQKSLLNEVNPVEKPPRRTDIE 496
                      ..:|...||:|::.                   .:.||.|.::|.
  Rat   575 PAAASAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPT---------- 629

  Fly   497 SVDGGDDVLEIKKTLLDDTVYVANHSRDE 525
                        .|.:.:...:..|::|:
  Rat   630 ------------VTTISEPYIIQTHTKDK 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/83 (28%)
		leucine-rich repeat	76..100	CDD:275380	5/23 (22%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	20/129 (16%)
		leucine-rich repeat	149..172	CDD:275380	11/93 (12%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	17/52 (33%)
		Ig	296..376	CDD:143165	21/80 (26%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	9/34 (26%)
		LRR_8	74..132	CDD:404697	14/59 (24%)
		LRR 1	75..96		4/22 (18%)
		leucine-rich repeat	76..99	CDD:275380	5/24 (21%)
		PPP1R42	96..300	CDD:411060	42/203 (21%)
		LRR 2	99..120		4/20 (20%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR 3	123..144		6/20 (30%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR 4	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR 5	171..193		0/21 (0%)
		leucine-rich repeat	172..196	CDD:275380	0/23 (0%)
		LRR 6	196..217		0/20 (0%)
		leucine-rich repeat	197..218	CDD:275380	0/20 (0%)
		LRR 7	218..239		3/20 (15%)
		leucine-rich repeat	219..242	CDD:275380	4/22 (18%)
		LRR 8	242..263		3/20 (15%)
		leucine-rich repeat	243..266	CDD:275380	4/22 (18%)
		LRR 9	266..287		7/20 (35%)
		leucine-rich repeat	267..288	CDD:275380	7/20 (35%)
		LRRCT	299..350	CDD:214507	17/53 (32%)
		IG_like	358..440	CDD:214653	24/94 (26%)
		Ig strand B	369..373	CDD:409353	1/3 (33%)
		Ig strand C	380..384	CDD:409353	1/3 (33%)
		Ig strand E	406..410	CDD:409353	1/3 (33%)
		Ig strand F	420..425	CDD:409353	3/4 (75%)
		Ig strand G	433..436	CDD:409353	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910