DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRRC4

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	684	Identity:	140/684 - (20%)
Similarity:	227/684 - (33%)	Gaps:	226/684 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGMILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQ 76
            |..:.|...|.::..|:   .|..:...|:| ..|.|. |...|.. |..:.|:::||.:.:..:
Human    19 LPFVYLTAQVWILCAAI---AAAASAGPQNCPSVCSCS-NQFSKVV-CTRRGLSEVPQGIPSNTR 78

  Fly    77 VLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPG 141
            .|:...|.|..::.:.|  ..|.::..:.|...:|:::...||.||..|..|:|..|.:..:..|
Human    79 YLNLMENNIQMIQADTF--RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSG 141

  Fly   142 TFAGLEKLRNVIINNNEIEVLP------------------------------------------- 163
            .|..|.|||.:.:.||.||.:|
Human   142 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMC 206

  Fly   164 ---------------------NHL-------FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAI 200
                                 ||.       |..||.|.::...|:::..::.:.|.|..:|..:
Human   207 NIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVEL 271

  Fly   201 SLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTD-----CQEPP 260
            :|..|.||.|..:.|..|:.|:.|.|..|.|||.|   |....|...|.|.|...     |..|.
Human   272 NLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDC---DILWLAWWLREYIPTNSTCCGRCHAPM 333

  Fly   261 QLRGKLWSEVPSENFAC-RPRILGSVRSFIEANHDNIS------LPCRIVGSPRPNVTWVYNKRP 318
            .:||:...||...:|.| .|.|:.:.|..      |||      |.||.  .|..:|.|:.
Human   334 HMRGRYLVEVDQASFQCSAPFIMDAPRDL------NISEGRMAELKCRT--PPMSSVKWLL---- 386

  Fly   319 LQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVS--- 380
                 |...||:...:.| :.|.:....|....|..||.|.|||:..|..|.:.|...|.||
Human   387 -----PNGTVLSHASRHP-RISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAE 445

  Fly   381 -------------------------GDYAGAVSASDGMGMG----------------AIGAPTID 404
                                     ..|....:.|.|....                .:..|..|
Human   446 LNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATD 510

  Fly   405 P------------QTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSK 457
            .            :|...:|.|.:..|   ||..|:|.:|:..|  |.:|:.:|:.:...:...:
Human   511 TTDKMQTSLDEVMKTTKIIIGCFVAVT---LLAAAMLIVFYKLR--KRHQQRSTVTAARTVEIIQ 570

  Fly   458 MDK------------THNGSMLEGSVIME-------------------MQKSLLNEVNPVEKPPR 491
            :|:            ..:|...||:|::.                   .:.||.|.::|.
Human   571 VDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPT----- 630

  Fly   492 RTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDE 525
                             .|.:.:...:..|::|:
Human   631 -----------------VTTISEPYIIQTHTKDK 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/83 (28%)
		leucine-rich repeat	76..100	CDD:275380	5/23 (22%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	20/129 (16%)
		leucine-rich repeat	149..172	CDD:275380	11/93 (12%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	17/52 (33%)
		Ig	296..376	CDD:143165	24/85 (28%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	9/34 (26%)
		LRR	<74..291	CDD:227223	43/218 (20%)
		LRR 1	76..97		4/22 (18%)
		leucine-rich repeat	77..100	CDD:275380	5/24 (21%)
		LRR 2	100..121		4/20 (20%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR 3	124..145		6/20 (30%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR 4	148..169		8/20 (40%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		LRR 5	172..194		0/21 (0%)
		leucine-rich repeat	173..197	CDD:275380	0/23 (0%)
		LRR 6	197..218		0/20 (0%)
		leucine-rich repeat	198..219	CDD:275380	0/20 (0%)
		LRR 7	219..240		3/20 (15%)
		leucine-rich repeat	220..243	CDD:275380	4/22 (18%)
		LRR 8	243..264		3/20 (15%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..289	CDD:275380	7/20 (35%)
		LRRCT	300..351	CDD:214507	17/53 (32%)
		IG	359..441	CDD:214652	27/99 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910