DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRFN1

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_065913.1	Gene:	LRFN1 / 57622	HGNCID:	29290	Length:	771	Species:	Homo sapiens

Alignment Length:	399	Identity:	108/399 - (27%)
Similarity:	155/399 - (38%)	Gaps:	73/399 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PPPT---------AGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQI 85
            |||.         ||.:......|.|.||..:...:..|....|..:|..:...:..|....|.|
Human    13 PPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFI 77

  Fly    86 PELRREEFLLAGLPN-VHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKL 149
            ..:||.:|  |.:.: ||....|| ||.:|...||..|..|..|.|..||:.|:......||..|
Human    78 AAVRRRDF--ANMTSLVHLTLSRN-TIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNL 139

  Fly   150 RNVIINNNEIEVLPNHLFVNLSFLSRIE---FRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLH 211
            |::|:.||:|..:.:..|.  :|||.:|   ...|.|..:........:.|:.::|:.|.:.|:.
Human   140 RHLILGNNQIRRVESAAFD--AFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIA 202

  Fly   212 KETFKDLQKLMHL--------------------------------SLQGNAWNCSCELQDFRDFA 244
            :.||..|.||:.|                                |..||..:|:|||...|...
Human   203 EGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLT 267

  Fly   245 ISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRIL----GSVRSFIEANHDNISLPCRIVGS 305
            ....|.|    |..|..|..:.:..:|.|.|.|.|.::    |.....:|.  ..:||.||.||.
Human   268 REDDLET----CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEG--QAVSLRCRAVGD 326

  Fly   306 PRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGR 370
            |.|.|.||.....|.....|.||....           |.::.|..:|  |.|.:||:|.|..|.
Human   327 PEPVVHWVAPDGRLLGNSSRTRVRGDG-----------TLDVTITTLR--DSGTFTCIASNAAGE 378

  Fly   371 AEAEFQLLV 379
            |.|..::.|
Human   379 ATAPVEVCV 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/84 (36%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		LRR_8	99..159	CDD:290566	23/60 (38%)
		leucine-rich repeat	101..124	CDD:275380	10/22 (45%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	16/61 (26%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	5/25 (20%)
		LRR_8	197..>229	CDD:290566	11/63 (17%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	14/47 (30%)
		Ig	296..376	CDD:143165	27/79 (34%)
LRFN1	NP_065913.1	LRR_RI	<65..174	CDD:238064	37/113 (33%)
		LRR_8	65..125	CDD:290566	21/62 (34%)
		LRR 1	66..87		6/22 (27%)
		leucine-rich repeat	67..90	CDD:275380	7/24 (29%)
		LRR 2	90..111		9/21 (43%)
		leucine-rich repeat	91..114	CDD:275380	10/23 (43%)
		LRR_8	113..174	CDD:290566	20/62 (32%)
		LRR 3	114..135		6/20 (30%)
		leucine-rich repeat	115..138	CDD:275380	8/22 (36%)
		LRR 4	138..159		7/22 (32%)
		leucine-rich repeat	139..163	CDD:275380	9/25 (36%)
		LRR_8	162..222	CDD:290566	14/59 (24%)
		LRR 5	163..184		3/20 (15%)
		leucine-rich repeat	164..187	CDD:275380	3/22 (14%)
		LRR_4	165..203	CDD:289563	7/37 (19%)
		LRR 6	187..208		6/20 (30%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 7	211..232		3/20 (15%)
		leucine-rich repeat	212..230	CDD:275380	2/17 (12%)
		LRRCT	252..>284	CDD:214507	11/35 (31%)
		IG_like	310..385	CDD:214653	28/89 (31%)
		Ig	314..387	CDD:299845	27/87 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422
		fn3	426..500	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..743
		PDZ-binding	768..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910