DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRFN2

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_065788.1	Gene:	LRFN2 / 57497	HGNCID:	21226	Length:	789	Species:	Homo sapiens

Alignment Length:	827	Identity:	184/827 - (22%)
Similarity:	272/827 - (32%)	Gaps:	218/827 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSCGT-CHCQWNSGKKSADCKNKALTKIPQDMSNEMQVL 78
            |..||.|:|...||...        :.:|.. |.||..|......|.:|.|..:|.|:......|
Human     1 METLLGGLLAFGMAFAV--------VDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVEL 57

  Fly    79 DFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTF 143
            ....|.|..:.|::|  |.:..:..:.|...||..:...:|..|..|..|.|..||:..|...|.
Human    58 RLGGNFIIHISRQDF--ANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTL 120

  Fly   144 AGLEKLRNVIINNNEIEVLPNHLFVN-LSFLSRIEFRNNRL---------RQVQLHVFAGTMALS 198
            .||..|:::|:|||::..:.:..|.: |..|..::...|.|         |.|.||
Human   121 RGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH--------- 176

  Fly   199 AISLEQNRLSHLHKETFKDLQKLMHLSLQ-----------------------------------G 228
            .:||:.|.|.|:.:.||.|||||..|.|.                                   |
Human   177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGG 241

  Fly   229 NAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGS-VRSFIEAN 292
            |..:|:|||...|.......|.|    |..|..|:|:.:..|..|.|.|.|.::.. ....:...
Human   242 NPLHCNCELLWLRRLERDDDLET----CGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLE 302

  Fly   293 HDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDK 357
            ....:|.|:.:|.|.|.:.||.....|.....|..|..:             ..|.|....:.|.
Human   303 GQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDN-------------GTLDIFITTSQDS 354

  Fly   358 GAYTCVADNRGGRAEAEFQLLV-------------------SGDYAGAVSASDGMGMGAIGAPTI 403
            ||:||:|.|..|.|.|..::.:                   ..|..|:...|.|.|....|.|..
Human   355 GAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPK 419

  Fly   404 DPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLE 468
            .|.....|:..:..|:.|:...|:.     ...|:|.||.... .|.|.::..:|....|.:.:.
Human   420 SPPERAVLVSEVTTTSALVKWSVSK-----SAPRVKMYQLQYN-CSDDEVLIYRMIPASNKAFVV 478

  Fly   469 GSVI------------MEMQKSLLNEVNPV---------EKPPRRTDIESVDGGDDVLE----IK 508
            .:::            .:...:.|...|.|         :.|..::....:.||..:|.    |.
Human   479 NNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIV 543

  Fly   509 KTLLDDTVY------VANH---SRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPAR 564
            .|||...|.      |.||   |:...|||...|.|.               .:.||...:.||.
Human   544 ATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTN---------------GAQPPPPSSAPAG 593

  Fly   565 VPPTSP-------------------SMQSSQSNIPDQVIYGI-----RSPPSLTSPVYTHMTPHG 605
            .||..|                   |..||.|::......|:     |.|||...|
Human   594 APPQGPPKVVVRNELLDFTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRP--------- 649

  Fly   606 IYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQH 670
               ..::......|.:|.....|...|:    .||...........:.||      ..::.....
Human   650 ---KPSLDRLMGAFASLDLKSQRKEELL----DSRTPAGRGAGTSARGHH------SDREPLLGP 701

  Fly   671 PLATTSPFLPAPV--------------VYSPATGVVMKQGYMTIPRK 703
            |.|.....||.|:              ..:.|.|.|:..|| :.|||
Human   702 PAARARSLLPLPLEGKAKRSHSFDMGDFAAAAAGGVVPGGY-SPPRK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	17/68 (25%)
		leucine-rich repeat	149..172	CDD:275380	7/23 (30%)
		leucine-rich repeat	173..196	CDD:275380	7/31 (23%)
		LRR_8	197..>229	CDD:290566	14/66 (21%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		LRRCT	229..277	CDD:214507	15/47 (32%)
		Ig	296..376	CDD:143165	22/79 (28%)
LRFN2	NP_065788.1	LRR 1	53..74		5/22 (23%)
		leucine-rich repeat	54..77	CDD:275380	6/24 (25%)
		LRR_8	76..136	CDD:316378	19/59 (32%)
		LRR 2	77..98		4/20 (20%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		LRR 3	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		LRR_8	125..185	CDD:316378	17/68 (25%)
		LRR 4	125..146		6/20 (30%)
		leucine-rich repeat	126..150	CDD:275380	7/23 (30%)
		LRR 5	150..171		3/20 (15%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		LRR_8	174..>215	CDD:316378	16/49 (33%)
		LRR 6	174..195		9/29 (31%)
		leucine-rich repeat	175..198	CDD:275380	11/31 (35%)
		LRR 7	198..219		4/20 (20%)
		LRRCT	242..286	CDD:214507	15/47 (32%)
		Ig	303..376	CDD:325142	22/85 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..424		8/40 (20%)
		fn3	420..493	CDD:306538	13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..602		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..654		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..702		6/43 (14%)
		PDZ-binding	786..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910