DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and AgaP_AGAP007059

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_001688062.1	Gene:	AgaP_AGAP007059 / 5666869	VectorBaseID:	AGAP007059	Length:	1098	Species:	Anopheles gambiae

Alignment Length:	235	Identity:	72/235 - (30%)
Similarity:	110/235 - (46%)	Gaps:	35/235 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 KNKALTKIPQDMS--NEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGL 122
            ||:..|..||...  :.:|.:||:.|.:..|  .:...|..|.:.|:.|.:..:||:.:|.|..:
Mosquito    84 KNQLETIDPQTFRGISYVQEIDFSGNLLRTL--PDLFFAEKPKLKKLSLADNFLQELKKETFGEM 146

  Fly   123 HILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQ 187
            ..|.|||||||.:|.|..|||.|..:|..:::.||.:||:....|.||..|..:...||.|:.:.
Mosquito   147 TALQELDLSGNMLRALVAGTFDGPWQLEQLLLQNNRLEVIEATAFENLVKLRGLNLSNNNLKVLP 211

  Fly   188 LHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNA---------WNCSCELQDFRDF 243
            ..||.....|..:.|:||.||||...||::..:|:.::|..|.         .|    |.|.:.|
Mosquito   212 ATVFNSMGVLRELELQQNYLSHLDSATFEENLRLVMINLDNNTIATLQPALIQN----LTDLQRF 272

  Fly   244 AI--------SKRLYTPPTDCQEPPQLRGKLWSEVPSENF 275
            :|        ..:|:...||.:       :||.   |.||
Mosquito   273 SIEYNQLQELDVQLFAHSTDLK-------RLWL---SGNF 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/83 (36%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	24/59 (41%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	13/22 (59%)
		leucine-rich repeat	125..148	CDD:275380	14/22 (64%)
		LRR_8	148..207	CDD:290566	18/58 (31%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	12/31 (39%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		LRRCT	229..277	CDD:214507	14/64 (22%)
		Ig	296..376	CDD:143165
AgaP_AGAP007059	XP_001688062.1	leucine-rich repeat	29..52	CDD:275380
		LRR_8	53..111	CDD:290566	9/26 (35%)
		leucine-rich repeat	53..76	CDD:275380
		leucine-rich repeat	77..100	CDD:275380	5/15 (33%)
		LRR_RI	80..377	CDD:238064	72/235 (31%)
		leucine-rich repeat	101..124	CDD:275380	6/24 (25%)
		LRR_8	123..183	CDD:290566	24/59 (41%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		leucine-rich repeat	149..172	CDD:275380	14/22 (64%)
		LRR_8	172..231	CDD:290566	18/58 (31%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRR_8	221..279	CDD:290566	18/61 (30%)
		leucine-rich repeat	221..244	CDD:275380	10/22 (45%)
		leucine-rich repeat	245..268	CDD:275380	5/26 (19%)
		leucine-rich repeat	269..292	CDD:275380	3/22 (14%)
		LRR_8	293..351	CDD:290566	5/20 (25%)
		leucine-rich repeat	293..316	CDD:275380	5/20 (25%)
		leucine-rich repeat	317..340	CDD:275380
		leucine-rich repeat	341..361	CDD:275380
		LRR_RI	365..>542	CDD:238064
		leucine-rich repeat	365..412	CDD:275380
		LRR_8	396..447	CDD:290566
		leucine-rich repeat	413..434	CDD:275380
		leucine-rich repeat	437..459	CDD:275380
		LRR_8	439..494	CDD:290566
		leucine-rich repeat	460..480	CDD:275380
		leucine-rich repeat	484..506	CDD:275380
		LRR_8	506..558	CDD:290566
		leucine-rich repeat	507..530	CDD:275380
		leucine-rich repeat	531..554	CDD:275380
		leucine-rich repeat	555..578	CDD:275380
		leucine-rich repeat	579..602	CDD:275380
		leucine-rich repeat	603..626	CDD:275380
		leucine-rich repeat	650..673	CDD:275380
		leucine-rich repeat	674..697	CDD:275380
		leucine-rich repeat	698..719	CDD:275380
		leucine-rich repeat	720..743	CDD:275380
		LRR_8	742..803	CDD:290566
		leucine-rich repeat	746..768	CDD:275380
		LRR_RI	<755..912	CDD:238064
		leucine-rich repeat	769..792	CDD:275380
		LRR_8	791..851	CDD:290566
		leucine-rich repeat	793..816	CDD:275380
		leucine-rich repeat	817..840	CDD:275380
		LRR_8	840..899	CDD:290566
		leucine-rich repeat	841..864	CDD:275380
		LRR	<856..>1095	CDD:227223
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..912	CDD:275380
		leucine-rich repeat	913..936	CDD:275380
		leucine-rich repeat	979..1000	CDD:275380
		leucine-rich repeat	1051..1074	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910