DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lingo2b

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001139054.1	Gene:	lingo2b / 564052	ZFINID:	ZDB-GENE-080723-57	Length:	607	Species:	Danio rerio

Alignment Length:	557	Identity:	124/557 - (22%)
Similarity:	201/557 - (36%)	Gaps:	169/557 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KSADCKNKALTKIPQDM---SNEMQVLDFAHNQI--------PELRREEFL-------------- 94
            :|...::..||.:|:..   .:|:.:||.:.|::        .|.||...|
Zfish   107 RSLRLRSNQLTLLPRGALAGLSELTLLDVSQNRLVILLDYGFEEQRRLRVLELSDNELVFIAPRA 171

  Fly    95 LAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVII----- 154
            .:||.::..:.|:.|.:..|...|...||.|..|.|....|.||...||.||.:|:::.:
Zfish   172 FSGLASLRSLTLQRCNLSTVPTHALAHLHGLTSLRLRDLGIAELQAHTFKGLPRLKHLEVDRWPL 236

  Fly   155 ----------------------NNNEIEVLPNHLF---VNLSF-------------LSRIE---F 178
                                  |...:.|:.|.|:   :|||:             :.|:|   .
Zfish   237 LEGFPTSALQGLNLSTLSITHTNLTSVPVVTNLLYLTHLNLSYSRIRVLPAGWLRGMDRLEVLRV 301

  Fly   179 RNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDF 243
            |...|..|:...|.|..:|..:.|..|||:.|.:..|...:.|..|.:..|...|.|.|:    :
Zfish   302 RQANLLSVEPQAFQGASSLRILDLCYNRLATLERSVFPVTEALQTLLIGQNPLVCDCRLR----W 362

  Fly   244 AISKRLYTPP-------TDCQEPPQLRGK-----LWSEVPSENFACRPRILGSVRSFIEANHDNI 296
            .:.:   |||       .:|..|..|.||     :.:::.......:||::.......:|.....
Zfish   363 LLER---TPPLLYGDVQPECSAPAPLAGKPLRDLVEAQISRYVICTKPRVISMASYPAQAEEGQR 424

  Fly   297 S-LPCRIVGSPRPNVTWVYNKRPLQQY-----DPRVRVLT--SVEQMPEQPSQVLTSELRIVGVR 353
            : |.|...|:|.|:|:|:   .||:::     ..||.|.|  |:|....:|
Zfish   425 AWLYCSADGAPPPSVSWL---TPLRRHITTKSTGRVVVHTNGSLEFRMAEP-------------- 472

  Fly   354 ASDKGAYTCVADNRGGRAEAEFQLLV--SGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLI---- 412
             .|.|.|.|||.|..|.|.....|.|  ||....|:.|:...        ..||..|..||
Zfish   473 -QDSGMYVCVASNPAGNATLSVTLAVKTSGIRDRALYANRSF--------LFDPDYNSSLINGTE 528

  Fly   413 -----ICLIITTLLL-----------LLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKT 461
                 :.|..||:|:           ::|...|.||.:.|             |.|        .
Zfish   529 EYTIRVVLDFTTILVSTAMGCLSFLGVVLFCFLLLFAWSR-------------GKG--------K 572

  Fly   462 HNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRTDIESV 498
            |.|| ::...:...:|...:|:... ..|||.:::.:
Zfish   573 HRGS-VDIQYVPRKRKGANSELTET-SGPRRVNMKMI 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	27/132 (20%)
		leucine-rich repeat	76..100	CDD:275380	9/45 (20%)
		LRR_8	99..159	CDD:290566	18/86 (21%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	10/22 (45%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	18/104 (17%)
		leucine-rich repeat	149..172	CDD:275380	7/52 (13%)
		leucine-rich repeat	173..196	CDD:275380	7/25 (28%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	12/59 (20%)
		Ig	296..376	CDD:143165	25/87 (29%)
lingo2b	NP_001139054.1	LRRNT	26..58	CDD:214470
		leucine-rich repeat	37..60	CDD:275380
		LRR_8	59..116	CDD:290566	1/8 (13%)
		leucine-rich repeat	61..81	CDD:275380
		LRR_RI	<103..214	CDD:238064	24/106 (23%)
		LRR_8	104..188	CDD:290566	16/80 (20%)
		leucine-rich repeat	106..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..177	CDD:275380	3/22 (14%)
		leucine-rich repeat	178..201	CDD:275380	5/22 (23%)
		LRR_8	201..260	CDD:290566	11/58 (19%)
		leucine-rich repeat	202..225	CDD:275380	10/22 (45%)
		leucine-rich repeat	226..271	CDD:275380	4/44 (9%)
		LRR_8	272..330	CDD:290566	13/57 (23%)
		leucine-rich repeat	272..295	CDD:275380	3/22 (14%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		leucine-rich repeat	320..338	CDD:275380	6/17 (35%)
		leucine-rich repeat	344..356	CDD:275378	3/11 (27%)
		LRRCT	352..394	CDD:214507	12/48 (25%)
		IG_like	419..497	CDD:214653	27/95 (28%)
		Ig	422..497	CDD:299845	26/92 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910