DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lrfn5b

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_683575.2	Gene:	lrfn5b / 555839	ZFINID:	ZDB-GENE-080327-20	Length:	765	Species:	Danio rerio

Alignment Length:	750	Identity:	175/750 - (23%)
Similarity:	272/750 - (36%)	Gaps:	178/750 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVL 78
            |.:||:.::||:|||      ....:|.| ..|.||......:..|..|.|..:|.::......|
Zfish     1 MEMLLVYLMVVVMAL------KAQKIQVCPKRCICQVLPPNLATLCDKKGLLFVPPNIDRRTVEL 59

  Fly    79 DFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTF 143
            ....|.|..::|::|  |.:..:..:.|...||..|...||..|..|..|.|..||:..:...||
Zfish    60 RLGDNFITGIKRKDF--ANMTKLVDLTLSRNTIGSVAPHAFNDLENLRALHLDSNRLTHITNDTF 122

  Fly   144 AGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLR-----QVQLHVFAGTMALSAISLE 203
            :|:.||.::|:|||::..:....|.:|..|..::...|.|.     .:||.:     :|..::|:
Zfish   123 SGMSKLHHLILNNNQLTYIHIGAFNDLLALEELDLSYNNLEGAPWIAIQLMI-----SLHTLNLD 182

  Fly   204 QNRLSHLHKETFKDLQKL---------MH--------------------------LSLQGNAWNC 233
            .|.::::.:.||..||||         :|                          ||..||..:|
Zfish   183 HNMINYIPEGTFSGLQKLKRLDVTSNKLHKLPPDPVFQRAGVLATSGVLGASTFALSFGGNPLHC 247

  Fly   234 SCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEA-NHDNIS 297
            :|||...|.......|.|    |..|..|.|:.:..|..|.|.|.|.::......:.| ....:|
Zfish   248 NCELLWLRRLRREDDLET----CAAPQHLAGRYFWTVSEEEFLCEPPLITRHSQEMRALEGQQVS 308

  Fly   298 LPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTC 362
            |.|:..|.|.|.:.||.....|.....|..|.|..           |.|:.|..|:  |.|::||
Zfish   309 LRCKARGDPDPIIHWVAPDGKLVFNSSRTVVHTDG-----------TLEILISTVK--DSGSFTC 360

  Fly   363 VADNRGGRAEAEFQLLV-------------------SGDYAGAVSASDGMGMGAIGAPTIDPQTN 408
            ||.|..|.|:....||:                   |.|.|.:...:||   |.....|...|..
Zfish   361 VASNPSGEAQQTVDLLITKLPHFTNDTSLAPEPDPGSSDIATSAKTADG---GPSIGNTKGGQEK 422

  Fly   409 MFLIICLIITTLLLLLLVAVLTLFWYCRR---IKTYQKDTTMMSGDGLI------SSKMDKTHN- 463
            ..||..:..:        :.|..|.:.|.   |:.:|........|.|:      :||....:|
Zfish   423 RVLISEITAS--------SALVRFNFQRNIPGIRMFQVQYNGTYDDSLVYRMIPPTSKSITVNNL 479

  Fly   464 --GSMLEGSVIMEMQKSL--LNEVNPVEKPPRRTDIESVD---------GGDDVLEIKKTLLDDT 515
              |:|.:..|:.....:|  |.....|......||.:.:.         ||..|:.|...::...
Zfish   480 AAGTMYDLCVLAIYDDALTTLTATRVVGCVHFSTDPQYMRCHFMQSQFLGGTIVVIIGGVIVASV 544

  Fly   516 V----------YVANHSRDEEAVSVAMSDTTTTPRSR-HTYVDDAYANSLPPDLLAFP----ARV 565
            :          .|......|:||.:.:.      ||: .|........|:...:|...    .:|
Zfish   545 LAFIIFLIVRYRVCQPDGSEKAVELGVI------RSQSETLQVCGVIKSMSKQVLGLERDACRKV 603

  Fly   566 PPTSPSMQSSQSNIPDQVI---YGIRS-PPSLTSPVYTHMTPHGIYGTKTMTAPHN--------- 617
            .|.:.|.::|:...||..:   .|..| .|:..||:  ..||    .|:....|.|
Zfish   604 SPQNESARASKPAFPDCTVSTSAGTHSWHPASPSPL--RHTP----DTQINVEPENTNKNNSAKA 662

  Fly   618 -----GFMTLQHPKSRNLALIATTNSSRQHQHHHQ 647
                 .:.|:..|.||...|        |..||:|
Zfish   663 RPAVRAYSTMVTPVSRRAQL--------QSLHHYQ 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	27/83 (33%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	21/59 (36%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	16/63 (25%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	5/27 (19%)
		LRR_8	197..>229	CDD:290566	12/66 (18%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	15/47 (32%)
		Ig	296..376	CDD:143165	25/79 (32%)
lrfn5b	XP_683575.2	LRR_RI	44..>245	CDD:238064	50/207 (24%)
		leucine-rich repeat	56..79	CDD:275380	6/24 (25%)
		LRR_8	78..138	CDD:290566	21/59 (36%)
		leucine-rich repeat	80..103	CDD:275380	7/22 (32%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	5/27 (19%)
		LRR_8	158..210	CDD:290566	13/56 (23%)
		LRR_4	175..215	CDD:289563	10/39 (26%)
		leucine-rich repeat	176..199	CDD:275380	6/22 (27%)
		I-set	290..377	CDD:254352	27/99 (27%)
		Ig	304..377	CDD:299845	26/85 (31%)
		fn3	426..495	CDD:278470	14/76 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910