DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrit3

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	XP_006232069.1	Gene:	Lrit3 / 502596	RGDID:	1559637	Length:	702	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	153/793 - (19%)
Similarity:	243/793 - (30%)	Gaps:	269/793 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WMQSC----------------GTCHCQWN-----SGKKSADCKNKALTKIPQDMSNEMQVLDFAH 82
            |:.:|                ..|.|:::     ||.:|..|.:..:.::|.::.     :|.|
  Rat     2 WLFACLCLVLSFLGGVNCTCPSQCSCEYHGRHEGSGSRSVLCNDLDMNEVPTNLP-----VDTA- 60

  Fly    83 NQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELD---LSGNRIRELHPGTFA 144
                                |:.:....::.:..|||   :.|:||.   |:.|.:..:...:|.
  Rat    61 --------------------KLRIEKTVVRRIPAEAF---YYLVELQYLWLTYNSVASIETRSFY 102

  Fly   145 GLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRL-- 207
            .|::|..:.::.|.:...|....:::..|..::..|||:..|..........|:.:.|..|||
  Rat   103 NLKQLHELRLDGNSLTEFPWASLLDMPHLRTLDLHNNRITSVTNEAVRYLRNLTCLDLSSNRLTT 167

  Fly   208 ---------SHLHKETFK--DL-QKLMHLSLQGNAWNCSC------ELQDFRDFAISKRLYTPPT 254
                     |||.....:  || .|.:.|.||.|.|.|.|      ||....|.|..  |..|..
  Rat   168 LPPDFLDSWSHLAMTPSRSPDLPPKRIILGLQDNPWFCDCHISKVIELSKVADHAAV--LLDPLM 230

  Fly   255 DCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWV-YNKRP 318
            .|.||..|:|..:..|..|. ..:|.::.|......|...|:.|.|...|.|.|.:.|. .:..|
  Rat   231 VCSEPEYLQGIAFQRVELEK-CLKPSVMMSATKITSALGSNVLLRCDAKGYPTPQLMWTRSDSSP 294

  Fly   319 LQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDY 383
            :.        .|.:::.|.:  .|..|.|.:.|:...|.|.|:|.|.|..|.:||...:.|.|
  Rat   295 VN--------ATVIQESPGE--GVRWSILSLTGITYRDAGDYSCKAKNLAGTSEAVVTVTVVG-- 347

  Fly   384 AGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMM 448
                          :...|:.|.|
  Rat   348 --------------VATTTLSPDT----------------------------------------- 357

  Fly   449 SGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPRRTDIESVDGGDDVLEIKKTLLD 513
                                            :|.:|.|.|.:......:  |....:.|..|..
  Rat   358 --------------------------------SERSPGEHPEQNHPQPGL--GRSTPQSKSWLWP 388

  Fly   514 DTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSN 578
            ...|.::|.....|   |:|.:|.:|.          .:||||...|..|..        |.:::
  Rat   389 GLSYTSSHPTSSAA---ALSTSTLSPP----------PSSLPPIFSAASATT--------SVRTS 432

  Fly   579 IPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAPHNG--FMTLQHPKSRNLALIATTNSSRQ 641
            |....:.....||.|      |  |.|....|   ...||  |..|...|...|||:
  Rat   433 ISGSTVRTSHRPPLL------H--PGGKSNAK---IEKNGRKFPPLSASKKEELALM-------- 478

  Fly   642 HQHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRA 706
                                     .|..|:.|........|.......|.:
  Rat   479 -------------------------DQAAPMETNITIKDLRVARETGASVTL------------- 505

  Fly   707 PSWAPSTSGAAGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGN-STLNLT 770
             :|:.|:|.::...|...|...|.:|.:..|:..........|.  |.|.:....|.| :|:|
  Rat   506 -TWSSSSSSSSSSSSSSSSSSSSSSSSSIQESAVTVLYSKYGEK--DLLLVDADYGKNQATIN-- 565

  Fly   771 KIAGSQGGAGQQY 783
               |.:  .|.||
  Rat   566 ---GLE--PGSQY 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	15/86 (17%)
		leucine-rich repeat	76..100	CDD:275380	2/23 (9%)
		LRR_8	99..159	CDD:290566	13/62 (21%)
		leucine-rich repeat	101..124	CDD:275380	4/22 (18%)
		LRR	122..145	CDD:197688	6/25 (24%)
		leucine-rich repeat	125..148	CDD:275380	7/25 (28%)
		LRR_8	148..207	CDD:290566	11/58 (19%)
		leucine-rich repeat	149..172	CDD:275380	3/22 (14%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	14/45 (31%)
		leucine-rich repeat	197..220	CDD:275380	10/36 (28%)
		LRRCT	229..277	CDD:214507	17/53 (32%)
		Ig	296..376	CDD:143165	22/80 (28%)
Lrit3	XP_006232069.1	LRR_8	61..117	CDD:290566	13/58 (22%)
		LRR_4	83..121	CDD:289563	7/37 (19%)
		leucine-rich repeat	83..106	CDD:275378	5/22 (23%)
		LRR_8	105..165	CDD:290566	11/59 (19%)
		LRR_4	105..146	CDD:289563	8/40 (20%)
		leucine-rich repeat	107..130	CDD:275378	3/22 (14%)
		LRR_4	129..170	CDD:289563	10/40 (25%)
		leucine-rich repeat	131..154	CDD:275378	5/22 (23%)
		leucine-rich repeat	155..168	CDD:275378	5/12 (42%)
		IGc2	268..335	CDD:197706	20/76 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910