DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and pxdn

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001076815.1	Gene:	pxdn / 493201	XenbaseID:	XB-GENE-923300	Length:	1460	Species:	Xenopus tropicalis

Alignment Length:	1047	Identity:	218/1047 - (20%)
Similarity:	352/1047 - (33%)	Gaps:	310/1047 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLD 79
            :.|..|:|||  |||       ....|| ..|.|    .:.:..|.:..|..:|. :.....:||
Frog    11 LYLTAGLLVV--ALP-------QLSHSCPSRCLC----FRTTVRCMHLMLESVPA-VPPHTTILD 61

  Fly    80 FAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFA 144
            ...|:|.:::...|  ..|.|::.:.|.|..|:.:..||||.|..|..|.|..|.|:.:....|.
Frog    62 LRFNRIKDIQTGAF--KHLKNLNTLLLNNNQIKRIPSEAFKDLENLKYLYLYKNEIQSIDRQAFK 124

  Fly   145 GLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSH 209
            ||..|..:.::.|:||.|....|   ::|.::|                     .:.|..||::|
Frog   125 GLASLEQLYLHFNQIETLEPESF---NYLPKLE---------------------RLFLHNNRITH 165

  Fly   210 LHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYT------PPTDCQEPPQLRGKLWS 268
            |...||..|:.:..|.|..||.:|.||:....|..   ::|:      ....|:.|.:|:|:..|
Frog   166 LVPGTFSQLESMKRLRLDSNALHCDCEILWLADLL---KIYSESGNAQAAATCEYPRRLQGRSVS 227

  Fly   269 EV-PSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPL-QQYDPRVRVLTS 331
            .: |||....||||....:.......:.:...||..|:|:|.:.|:.|...| .:.|.|:.:|..
Frog   228 TITPSELNCERPRITSEPQDVDVTFGNTVYFTCRAEGNPKPEIIWLRNNNELSMKDDSRLNLLND 292

  Fly   332 VEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEA-EFQLLVSGDYAGAVSASDGMGM 395
                         ..|.|...:.:|:|.|.|:|.|..|..:. |..|...|..|
Frog   293 -------------GTLMIQNTKETDQGIYQCMAKNVAGEVKTHEVTLRYYGTPA----------- 333

  Fly   396 GAIGAPT--IDPQTNMFLIICLIITTLLLLLLVAVLTLFWYCR-------RIKTYQKDTTMMSGD 451
                .||  |.||...             :|:...:||  .|.       |:...:.|.|.:..|
Frog   334 ----TPTFVIQPQNTE-------------VLVGESVTL--ECSATGQPHPRVTWTRGDRTPLPSD 379

  Fly   452 GLISSKMDKTHNGSMLEGSVIMEMQKSLLNE-----VNPVEK------------------PPRRT 493
                .:::.|.:|    |..|..:.:....|     .|.||.                  |..|.
Frog   380 ----PRINITPSG----GLYIQNVNQDDAGEYTCFATNSVETIHSTAYIIVQAVPQFTVVPQDRN 436

  Fly   494 DIE--SVD-----------------GGDDV-LEIKKTLLDD----TVYVANHSRDE---EAVSVA 531
            ..|  :||                 ||:.: ::.:..:|..    .:.||.|.:.:   :||::.
Frog   437 VFEGHTVDFHCEAQGNPKPVIAWTKGGNQLSVDRRHQVLSSGTLRILRVALHDQGQYECQAVNIV 501

  Fly   532 MSDTTTTPRSRHTYVDDAYANSLPPDL---LAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSL 593
            .|.:|.......|.|...:| ::|.|:   :....::|      .|||.: |..:|...:....:
Frog   502 GSKSTAAQLIVQTRVTPVFA-TVPNDMTVEVGTDVQIP------CSSQGD-PLPIITWNKDGIQV 558

  Fly   594 TSPVYTHMTPHGIYGTKTMTAPHNG-----------------FMTLQHPK-SRN---------LA 631
            |.....|::|||....:.......|                 .:::..|: ||.         :.
Frog   559 TESGKFHISPHGYLAIRDAGLADQGRYECVARNPIGYSSVSMVLSVLVPEVSRTGDPFVATSIIE 623

  Fly   632 LIATT----NSSRQH-------------------QHHHQLQQQQQHHHHHQQQQQQQQQQQHPLA 673
            .|||.    ||:|.|                   :..:.::|.:......:..|..|...|..|.
Frog   624 AIATVDRAINSTRTHLFDSRPRSPGDLLALFRYPRDPYTVEQARAAEIFERTLQLIQDHVQSGLM 688

  Fly   674 TTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRAPSWAPSTSGAAGHGSI---------QLSEFQS 729
            .            ...|.......:.   .|:..:...:.||.|.|..|         |......
Frog   689 V------------DLNGTSYHYNDLV---SPQYLNMIANLSGCATHRRINNCSNMCFHQKYRTHD 738

  Fly   730 PTSPN---PSETGTATTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQGGAGQQYSMRDRPLP 791
            .|..|   |....:.|..|...:.||:|           ..||.:     |.:|:.|:....|||
Frog   739 GTCNNLQHPMWGASLTAFERLLKSVYEN-----------GFNLPR-----GISGRIYNGFPLPLP 787

  Fly   792 ATPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQQQQQQRLG-SMDTEPLYGVRQQGITILPGS 855
            ...|.|.:.:.|            |...:|......|..|.|. .:|:           |::..|
Frog   788 RLVSTTLIGTHT------------ITPDEQFTHMLMQWGQFLDHDLDS-----------TVVALS 829

  Fly   856 SISGAGLGHAAYLSPGSGAAVSPSHASSSGDSP-KAAKIPPRPPPKPKKKMSVTTTRS----GQG 915
            .         |..|.|...:|     ..:.|:| ....:||..|........::..||    |.|
Frog   830 Q---------ARFSDGQDCSV-----VCTNDAPCFPIMVPPNDPRVRNNARCMSMVRSSPVCGSG 880

  Fly   916 STSQLFD 922
            .||.|.:
Frog   881 MTSLLMN 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR	122..145	CDD:197688	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	10/58 (17%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	2/22 (9%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	15/54 (28%)
		Ig	296..376	CDD:143165	21/81 (26%)
pxdn	NP_001076815.1	leucine-rich repeat	38..56	CDD:275380	3/18 (17%)
		LRR	<54..235	CDD:227223	56/209 (27%)
		leucine-rich repeat	57..80	CDD:275380	6/24 (25%)
		LRR_8	104..163	CDD:338972	18/82 (22%)
		leucine-rich repeat	105..128	CDD:275378	8/22 (36%)
		leucine-rich repeat	129..152	CDD:275378	7/25 (28%)
		leucine-rich repeat	153..176	CDD:275378	9/43 (21%)
		leucine-rich repeat	177..189	CDD:275378	4/11 (36%)
		I-set	239..326	CDD:369462	24/99 (24%)
		I-set	335..422	CDD:369462	21/109 (19%)
		Ig3_Peroxidasin	439..512	CDD:143222	13/72 (18%)
		Ig4_Peroxidasin	535..603	CDD:143223	12/74 (16%)
		peroxidasin_like	856..1295	CDD:188658	9/32 (28%)
		VWC	1402..1452	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910