DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and lingo1b

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001004576.1	Gene:	lingo1b / 447837	ZFINID:	ZDB-GENE-040912-136	Length:	622	Species:	Danio rerio

Alignment Length:	587	Identity:	117/587 - (19%)
Similarity:	193/587 - (32%)	Gaps:	198/587 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLD 79
            :::|:||.::...|...|:             .|:.::.::|..|..:.|..:|:.:..:.::||
Zfish    28 ILILMLGTVLSGSATGCPS-------------RCECSAQERSVVCHRRKLITLPEGIPIDTRLLD 79

  Fly    80 FAHNQIPELRREEFL----------------------LAGLPNVHKIFLRNCTIQEVHREAFKGL 122
            .:.|::..:..||||                      .:.|..:..:.|||..::.:....|.||
Zfish    80 LSKNRLKAINPEEFLNYPQLEDLQLNENIISVIEPGAFSNLLGLRTLGLRNNNLKLIQLGVFTGL 144

  Fly   123 HILIELDLSGNRI--------------RELHPG----------TFAGLE---------------- 147
            ..|..||:|.|:|              :||..|          .|.||.
Zfish   145 SNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRAFHGLSSLEQLTMERCNLTSVP 209

  Fly   148 -------------KLR----NVI---------------------------------------INN 156
                         |||    |||                                       |.|
Zfish   210 TEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESLTAKSLHGLNITTLSITN 274

  Fly   157 NEIEVLP----NHL----FVNLSF----------------LSRIEFRNNRLRQVQLHVFAGTMAL 197
            ..:..:|    .||    |.||||                |........||..::.:.|.|...|
Zfish   275 CNLTAVPYVAIQHLVYLRFFNLSFNPIEVVEGNKMHNLLRLQAFHLVGGRLVSIEPYSFKGLNYL 339

  Fly   198 SAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDF--RDFAISKRLYTPPTDCQEPP 260
            ..:::..|.||.|.:..|..:..|..|:|..|...|.|.|...  |.:.::.....|  .|:.|.
Zfish   340 RVLNVSSNSLSTLEESAFHSVGNLETLALHDNPLACDCRLLWVFRRRWRLNFNRQQP--SCETPE 402

  Fly   261 QLRGKLWSE----VPSENFACRP---RILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRP 318
            .|:||.:.:    :|...|.|:.   |...::..|::.. ..:..||:..|.|.|.:.|
Zfish   403 FLQGKEFKDFPDVLPPNYFTCQKSKIRDHKAIHRFVDEG-TTVQFPCQADGDPTPMIMW------ 460

  Fly   319 LQQYDPRVRVLT--SVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSG 381
               ..|:.:.:|  |:.::    |..|...|.:...:..|.|.|||.|.|.||. :.....|...
Zfish   461 ---QSPKKQFITTKSIGRL----SVSLDGTLEVRYAQIQDNGTYTCFAVNAGGN-DTRLAHLHVH 517

  Fly   382 DYA---------------GAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVLTL 431
            .|:               ...|.:...|.||:.....|.:|.:.......|:.|.::|...||..
Zfish   518 SYSPNWPHQPNKTFAFILNQPSDNSANGTGAMDPFPFDMKTLIIATTMGFISFLGVVLFCLVLLF 582

  Fly   432 FW 433
            .|
Zfish   583 LW 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	34/201 (17%)
		leucine-rich repeat	76..100	CDD:275380	8/45 (18%)
		LRR_8	99..159	CDD:290566	26/155 (17%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	11/46 (24%)
		leucine-rich repeat	125..148	CDD:275380	12/75 (16%)
		LRR_8	148..207	CDD:290566	23/125 (18%)
		leucine-rich repeat	149..172	CDD:275380	13/73 (18%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	13/53 (25%)
		Ig	296..376	CDD:143165	21/81 (26%)
lingo1b	NP_001004576.1	LRRNT	43..77	CDD:214470	6/46 (13%)
		LRR 1	74..95		6/20 (30%)
		leucine-rich repeat	75..98	CDD:275380	7/22 (32%)
		LRR_8	76..133	CDD:290566	11/56 (20%)
		LRR_RI	78..>315	CDD:238064	42/236 (18%)
		LRR 2	98..119		0/20 (0%)
		leucine-rich repeat	99..146	CDD:275380	7/46 (15%)
		LRR 3	122..143		4/20 (20%)
		LRR_8	130..181	CDD:290566	13/50 (26%)
		LRR 4	146..167		6/20 (30%)
		leucine-rich repeat	147..170	CDD:275380	6/22 (27%)
		LRR_8	170..226	CDD:290566	8/55 (15%)
		LRR 5	170..191		4/20 (20%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		LRR 6	194..215		0/20 (0%)
		leucine-rich repeat	195..218	CDD:275380	0/22 (0%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	6/22 (27%)
		leucine-rich repeat	243..290	CDD:275380	5/46 (11%)
		LRR_8	266..325	CDD:290566	11/58 (19%)
		LRR 8	266..287		3/20 (15%)
		LRR 9	290..311		5/20 (25%)
		leucine-rich repeat	291..338	CDD:275380	10/46 (22%)
		LRR_8	314..373	CDD:290566	15/58 (26%)
		LRR 10	314..335		4/20 (20%)
		LRR 11	338..359		6/20 (30%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		TPKR_C2	371..424	CDD:301599	13/54 (24%)
		IG_like	438..516	CDD:214653	22/92 (24%)
		Ig	441..516	CDD:299845	22/89 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000