DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Tollo

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	155/783 - (19%)
Similarity:	258/783 - (32%)	Gaps:	257/783 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DCKNKALTKIPQDMSNEMQVLDF-------------AHNQIPELRREEFLLAGLPNVHKIFLRNC 109
            ||....|.|:.::...:.|::|.             :|..:.|.:.::||.....  |...|.:|
  Fly   683 DCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYAS--HCFALCHC 745

  Fly   110 --------------------------TIQEVHREAFKGL---HILI---ELDLSGNRIRELHPGT 142
                                      .:.:..|.:::..   ||.:   :|.|.||..|||....
  Fly   746 CDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHA 810

  Fly   143 FAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRL 207
            |.|.::|:.:.:|::.||||.|..|..|..|..::.::|:|:.:..:.|.|...|..:.|:.|.:
  Fly   811 FIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAI 875

  Fly   208 SHLHKETFKDLQKLMHLSLQGNA-----------------------WNCSCELQD-FRDFAISKR 248
            :.:...||..|..|..|.|..||                       |.||||..| .||: |::.
  Fly   876 ATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKLRDY-INRH 939

  Fly   249 LYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWV 313
            .|..                                         |.:.:.|.::..
  Fly   940 EYVV-----------------------------------------DKLKMKCDVISG-------- 955

  Fly   314 YNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCV------ADNRGGRAE 372
                            .|.:||...|.....:.|.:|          .|.      .||....||
  Fly   956 ----------------NSTQQMVIYPGSGEPASLPVV----------QCSQTLPLGLDNNFNYAE 994

  Fly   373 AEFQLLVSGDYAGAVSASDGMGMGAI--GAPTIDPQTNMFLIICLIITTLLLLLLVAVLTLFWYC 435
                      .||..:||:......|  ..|.:|     ::.|.:.|.|..:.:::.:..:|.:.
  Fly   995 ----------QAGGENASNATSTKMILNQPPKLD-----YIPILVAILTAFIFVMICISLVFIFR 1044

  Fly   436 RRIKTY-------------QKDTTMMSGDGLISSKMDKTHNGSML---EGSVIMEM----QKSLL 480
            :.::.:             |||......:.|..:.:..:....:.   |.:.::||    .|..|
  Fly  1045 QEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCL 1109

  Fly   481 NEVN-PVEKPPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDE----EAVSVAMSDTTTTPR 540
            ::.: ||......|.::::|..      ::|::   |...|..:.|    |..|...|  ....|
  Fly  1110 HQRDFPVGGYLPETIVQAIDSS------RRTIM---VVSENFIKSEWCRFEFKSAHQS--VLRDR 1163

  Fly   541 SRHTYV---DDAYANSLPPDL--------------LAFPARVPPTSPSMQSSQ-SNIPDQVIYGI 587
            .|...|   .:.....|.|||              ..|..::....|.:.||| ||:..|
  Fly  1164 RRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQ----- 1223

  Fly   588 RSPPSLTSPV----YTHMTPHGIYGTKTMTAPHN------GFMTLQHPKSRNLALIATTNSSRQH 642
                |...|:    |.|   |.....:.|..||:      .||....|:.        ..|.|:.
  Fly  1224 ----SCHVPINHASYHH---HHHVHQQAMPLPHSVHHHQQQFMLPPPPQQ--------PGSFRRQ 1273

  Fly   643 QHHHQLQQQQQHHHHHQQQQQQQQQQQHPLATTSPFL--PAPVVYSPATGVVMKQGYMTIPRKPR 705
            ...||.|||||....:....|||||||..|......:  |||.:. |..|.:.:|.....|.:..
  Fly  1274 PSLHQQQQQQQQIRGNNNTTQQQQQQQAALLMGGGSVGGPAPQMI-PLAGGIQQQSLPLPPNQQP 1337

  Fly   706 APS 708
            .|:
  Fly  1338 TPA 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	23/128 (18%)
		leucine-rich repeat	76..100	CDD:275380	6/36 (17%)
		LRR_8	99..159	CDD:290566	17/91 (19%)
		leucine-rich repeat	101..124	CDD:275380	4/51 (8%)
		LRR	122..145	CDD:197688	10/28 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/25 (36%)
		LRR_8	148..207	CDD:290566	17/58 (29%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	12/71 (17%)
		Ig	296..376	CDD:143165	12/85 (14%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..452	CDD:275380
		leucine-rich repeat	453..500	CDD:275380
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380	2/4 (50%)
		leucine-rich repeat	689..816	CDD:275380	23/128 (18%)
		LRR_8	815..875	CDD:290566	17/59 (29%)
		leucine-rich repeat	817..864	CDD:275380	14/46 (30%)
		LRR_8	864..921	CDD:290566	11/56 (20%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	5/20 (25%)
		TIR	1076..1211	CDD:214587	24/145 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930