DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and LRRC24

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001019849.2	Gene:	LRRC24 / 441381	HGNCID:	28947	Length:	513	Species:	Homo sapiens

Alignment Length:	525	Identity:	135/525 - (25%)
Similarity:	209/525 - (39%)	Gaps:	106/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VVLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPE 87
            ::|:.||...||       | ..|.|.    ..:.:|....|..:|..:....|.|....|.|..
Human    11 LLLLLLPLRAAG-------CPAACRCY----SATVECGALRLRVVPLGIPPGTQTLFLQDNNIAR 64

  Fly    88 LRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNV 152
            |  |...||.|..:.:::|.|.:::.:...||:....|:||.|:.||:|.|..|.|.||.:||.:
Human    65 L--EPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVL 127

  Fly   153 IINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKD 217
            .:..|::..|.:..|::|..|..:..:.|.:..::....||..:|:.:.|.:|:|..:.:|..:.
Human   128 YLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQP 192

  Fly   218 LQKLMHLSLQGNAWNCSCELQ--------------DFRDFAISKRLYTPPTDCQEPPQLRGKLWS 268
            |..|..|.|..|.|.|.|.|.              ..||..|.         |.|||:|..:...
Human   193 LASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIM---------CAEPPRLALQSLL 248

  Fly   269 EVPSENFACRPRILGSVRSFIEAN-HDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSV 332
            :|...:..|.|..:......:.|| .:::.:.|:..|.|:|.|||  .|.|    .||
Human   249 DVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTW--RKVP----QPR------- 300

  Fly   333 EQMPEQPSQVLTSELRIVGVRASDKGA---------------YTCVADNRGGRAEAEFQLLVSGD 382
            |..|...:|:....|.:.|..|||.|:               |.|.|.|.||.|...|:|||:..
Human   301 EGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNAS 365

  Fly   383 Y----------------AGAVSASD--GMGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAVL 429
            .                ||:....:  .|...|:|..|   ||.:...|.|:  .|..|||||::
Human   366 RQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVAT---QTAIAAAIALL--ALTALLLVAMI 425

  Fly   430 TLFWYCRRIKTYQKDTTMMSGDG--LISSKMDKTHNGSMLE--------GSVIMEMQKSLLNEVN 484
                 ||| :..:|......|:|  .::..:|.....:.||        ...::...|.|..| .
Human   426 -----CRR-RRRRKKARGPPGEGALFVNDYLDGPCTFAQLEELRDERGHEMFVINRSKPLFAE-G 483

  Fly   485 PVEKP 489
            |.|.|
Human   484 PAEAP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	28/83 (34%)
		leucine-rich repeat	76..100	CDD:275380	9/23 (39%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	4/22 (18%)
		LRR	122..145	CDD:197688	10/22 (45%)
		leucine-rich repeat	125..148	CDD:275380	12/22 (55%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	14/61 (23%)
		Ig	296..376	CDD:143165	27/94 (29%)
LRRC24	NP_001019849.2	LRR_RI	49..>158	CDD:238064	33/110 (30%)
		LRR_8	<50..86	CDD:290566	11/37 (30%)
		LRR 1	51..72		7/22 (32%)
		leucine-rich repeat	53..75	CDD:275380	9/23 (39%)
		LRR 2	75..96		4/20 (20%)
		LRR_8	76..134	CDD:290566	19/57 (33%)
		leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		LRR 3	99..120		10/20 (50%)
		leucine-rich repeat	100..123	CDD:275380	12/22 (55%)
		LRR_8	123..205	CDD:290566	19/81 (23%)
		LRR 4	123..144		5/20 (25%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR 5	147..168		2/20 (10%)
		leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		LRR 6	171..192		5/20 (25%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		LRRCT	204..257	CDD:214507	14/61 (23%)
		Ig	259..364	CDD:299845	34/117 (29%)
		IG_like	266..362	CDD:214653	31/108 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..391		2/25 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870