DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and CG7896

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	202/992 - (20%)
Similarity:	338/992 - (34%)	Gaps:	313/992 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIREL 138
            |::.||.:.|.:.||  ...:...|.||..:.|....:..:....||.|..|..:||||..||::
  Fly   499 ELRSLDLSGNTLTEL--PSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQI 561

  Fly   139 HPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLE 203
            .....|||:.|:::.:|:|:::.|.:..||||..:|.|:..|||:..::...|...|.|..:.|.
  Fly   562 SGDLLAGLQDLKHIYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGSIRSGAFVNVMKLQKLDLH 626

  Fly   204 QNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWS 268
            .|:||                :.:|..:|....:::. |.:.::..|..|:..:..|:||
  Fly   627 GNQLS----------------AFKGEYFNTGTGIEEL-DISDNQLSYLFPSSFRIHPRLR----- 669

  Fly   269 EVPSEN--FACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNK-RPLQQYD----PRV 326
            |:.:.|  |:..|..|.|...::|  |.::|                :|: :.:::.|    ||:
  Fly   670 EIRAANNKFSFFPAELISTLQYLE--HIDLS----------------HNQLKTIEELDFARLPRL 716

  Fly   327 RVLTSVEQMPEQPSQVL---TSELRIVGVRASDKGAYTCVADNRG-----GRAEAEFQLLVSGDY 383
            |||.......:..|::.   :::|:|:.:..::       .|..|     |....| ||.:.|:.
  Fly   717 RVLLVANNQLDMVSEMAFHNSTQLQILDLAHNN-------LDRIGERTFEGLVRLE-QLNLEGNR 773

  Fly   384 AGAVSASDGMGMGAIGAPTIDPQTNMFLI--ICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTT 446
            ...:  |||          :..:|.:.::  |.|.........|.|:...|::...:........
  Fly   774 LSEL--SDG----------VFERTKLQMLENINLAHNRFEYAPLNALQRQFFFVSSVDLSHNKIK 826

  Fly   447 MMSGDGLI--------------SSKMDKTHN--------------GSMLEGSVIME--------M 475
            .:.||..|              |||  ..||              |:.:|...::|        :
  Fly   827 ELPGDDSIMVNIKRIDLSFNPLSSK--AVHNVLNEPKTVRELSLAGTGIENLELLETPFLQFLNL 889

  Fly   476 QKSLLNEVNPVEKPPRRTDIESVDGGDDVLEIKKTL------------LD------DTVYVANHS 522
            ..:.|..|.| |...|.|.:|::|...:.||..:.|            ||      :.|..:|..
  Fly   890 SHNKLKNVKP-EVFQRVTLLETLDLSSNQLESLEDLSMAWPQLQVLQSLDVSNNSFEIVSQSNFG 953

  Fly   523 RDEEAVSVAMSDTTTTPRSRHT--------------------YVDDAYANSLPPDLLAFPARVPP 567
            :.|...|:.:|......|....                    |:|......|.|.|......|..
  Fly   954 KLEMLRSLRLSHLPQCTRIEKNAFKQLPNLVSLEAYDLPLLGYLDLQGILELLPGLEVLDIEVKD 1018

  Fly   568 TSPSMQSSQ-----------------SNIPDQVIYGIRS---------------PPSLTSPVYTH 600
            :|...:..|                 .:|....:.|::|               ||:|..||
  Fly  1019 SSIGSEQIQPLKHPRLKSLGIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPV--- 1080

  Fly   601 MTPHGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQ 665
                          |.:..::|....|:...|:.        |..:.|:.:       :...|.|
  Fly  1081 --------------PRSSHLSLNVEGSKITVLVP--------QFLNALEDR-------RASLQLQ 1116

  Fly   666 QQQQHPLA-----------TTSPFLPAPVVYSPATGVVMK---------------------QGYM 698
            ....:|:.           ..|..:|.....|||..:..|                     :...
  Fly  1117 GLASNPIVCDCNARALRRWLPSSGMPDVTCASPAYLLNRKLIEVGDDELTCDARRMTSSTSRPTA 1181

  Fly   699 TIPRKPRAPSWAPSTSGAAGHGSIQLSEFQSPTSPNPSETGTATTAELQ--AEPVYDN-----LG 756
            ::|...:..|...:.|.:.....:.:...: ||.| ||.....|.|.|.  ..|:..|     :|
  Fly  1182 SVPHLLKTSSQLVTRSSSTTEEPLIIWSLE-PTQP-PSLKKMKTKAPLMKAQSPIISNDDTLIIG 1244

  Fly   757 LRTTAGG--------------------NSTL--NLTKI---AGSQGGA-GQQYSMRD---RPLPA 792
            :   .||                    |:..  |.|.|   ||.|.|| ...|:.::   ..|.|
  Fly  1245 I---VGGVVAFIAILIIIICIIRLRMSNAEYQQNATMIGIPAGMQMGAHNAAYNYKNGAGAALYA 1306

  Fly   793 TPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQQQQQQRLGSMDTEPLYGVRQQGITILPGSSI 857
            .|...:......||     ||:..|...|.|||||||||...:   ...|.      |:...|..
  Fly  1307 VPPYHATLPHKAAS-----IHQSSQNLSQRQQQQQQQQQVAAA---AAAYS------TMSRMSYF 1357

  Fly   858 SGAGLGHAAYLSPGSGA 874
            ||||.|:      |.||
  Fly  1358 SGAGGGN------GDGA 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	18/58 (31%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	5/31 (16%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		LRRCT	229..277	CDD:214507	10/49 (20%)
		Ig	296..376	CDD:143165	15/92 (16%)
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064	10/37 (27%)
		LRR_8	281..338	CDD:290566
		leucine-rich repeat	282..329	CDD:275380
		LRR_8	328..388	CDD:290566
		leucine-rich repeat	330..353	CDD:275380
		leucine-rich repeat	354..377	CDD:275380
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	428..451	CDD:275380
		LRR_8	429..487	CDD:290566
		leucine-rich repeat	452..473	CDD:275380
		leucine-rich repeat	477..497	CDD:275378
		LRR_8	498..558	CDD:290566	18/60 (30%)
		leucine-rich repeat	500..523	CDD:275380	6/24 (25%)
		LRR_RI	502..769	CDD:238064	75/316 (24%)
		leucine-rich repeat	524..547	CDD:275380	5/22 (23%)
		leucine-rich repeat	548..571	CDD:275380	10/22 (45%)
		LRR_8	572..630	CDD:290566	18/57 (32%)
		leucine-rich repeat	572..595	CDD:275380	8/22 (36%)
		leucine-rich repeat	596..619	CDD:275380	6/22 (27%)
		LRR_8	619..678	CDD:290566	15/80 (19%)
		leucine-rich repeat	620..643	CDD:275380	7/38 (18%)
		leucine-rich repeat	644..667	CDD:275380	3/23 (13%)
		LRR_8	666..726	CDD:290566	19/82 (23%)
		leucine-rich repeat	668..691	CDD:275380	8/27 (30%)
		leucine-rich repeat	692..715	CDD:275380	5/40 (13%)
		LRR_8	714..774	CDD:290566	15/67 (22%)
		leucine-rich repeat	716..739	CDD:275380	4/22 (18%)
		leucine-rich repeat	740..761	CDD:275380	4/27 (15%)
		leucine-rich repeat	764..789	CDD:275380	8/37 (22%)
		leucine-rich repeat	790..810	CDD:275380	4/19 (21%)
		leucine-rich repeat	818..850	CDD:275380	3/31 (10%)
		leucine-rich repeat	863..883	CDD:275378	3/19 (16%)
		LRR_RI	<878..1070	CDD:238064	31/192 (16%)
		LRR_8	884..944	CDD:290566	13/60 (22%)
		LRR_4	884..925	CDD:289563	10/41 (24%)
		leucine-rich repeat	884..907	CDD:275380	5/23 (22%)
		leucine-rich repeat	908..933	CDD:275380	5/24 (21%)
		leucine-rich repeat	934..955	CDD:275380	4/20 (20%)
		leucine-rich repeat	958..982	CDD:275380	3/23 (13%)
		leucine-rich repeat	983..1055	CDD:275380	9/71 (13%)
		leucine-rich repeat	1009..1033	CDD:275380	4/23 (17%)
		leucine-rich repeat	1058..1085	CDD:275380	6/43 (14%)
		TPKR_C2	1121..1168	CDD:301599	7/46 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840