DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and cDIP

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	278	Identity:	75/278 - (26%)
Similarity:	117/278 - (42%)	Gaps:	55/278 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 MQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKI 104
            |:.||.....|.:....||               ::.:|..:.|.|..|..:.|..||  |:..|
  Fly   123 MRGCGIRFIYWENFSIGAD---------------KLVILLLSDNHIEVLPTKTFRGAG--NLEFI 170

  Fly   105 FLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVN 169
            ||....:.::...||..|..|..|||:.||:..|....||||:.||:|.:..|::..:.:.||.:
  Fly   171 FLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAH 235

  Fly   170 LSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQ---KLMHLSLQGNAW 231
            ...|..:..:|||||:|..:.|            ::|..| |:..:.||.   :|:.|.|..||.
  Fly   236 NPDLLSVAMQNNRLREVGEYAF------------RSRGRH-HQMQYVDLSNNPELVVLLLNINAT 287

  Fly   232 NC---SCELQ-----------DFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRIL 282
            |.   :|.|.           |..|..: :.||.|.::..|...||..  |.|...:.:..||:
  Fly   288 NLTARNCSLDRVNLYGSVTNVDLSDNRV-RELYFPASEALEHLVLRNN--SLVQLASLSRVPRL- 348

  Fly   283 GSVRSFIEANHDNI-SLP 299
               |....|::.|: .||
  Fly   349 ---RHLDVADNPNLGQLP 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	29/83 (35%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		LRR_8	99..159	CDD:290566	22/59 (37%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	11/22 (50%)
		LRR_8	148..207	CDD:290566	14/58 (24%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	197..>229	CDD:290566	8/34 (24%)
		leucine-rich repeat	197..220	CDD:275380	5/25 (20%)
		LRRCT	229..277	CDD:214507	15/61 (25%)
		Ig	296..376	CDD:143165	2/5 (40%)
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/33 (18%)
		LRR_RI	143..407	CDD:238064	69/243 (28%)
		leucine-rich repeat	143..166	CDD:275380	7/24 (29%)
		LRR_8	166..225	CDD:290566	22/58 (38%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		leucine-rich repeat	191..214	CDD:275380	11/22 (50%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..265	CDD:275380	10/38 (26%)
		leucine-rich repeat	266..325	CDD:275380	15/59 (25%)
		LRR_8	304..357	CDD:290566	14/59 (24%)
		leucine-rich repeat	326..347	CDD:275380	5/22 (23%)
		leucine-rich repeat	348..394	CDD:275380	5/20 (25%)
		LRR_8	369..428	CDD:290566
		LRR_4	393..433	CDD:289563
		leucine-rich repeat	395..418	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930