DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and 2mit

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	178/923 - (19%)
Similarity:	289/923 - (31%)	Gaps:	299/923 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 FKG-LHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHL--------FVNL---- 170
            :|| ..::..:|||.|::..|....|   .:||.:.:.||.:||:|..|        ||.|
  Fly   116 WKGDFQVITAMDLSSNQLESLSLDNF---NQLRQLDLGNNSLEVIPLSLADTNMSLPFVTLDLSC 177

  Fly   171 --------SF-------LSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQK 220
                    ||       |..:...:|.|..:....|...:.|..:.|..|.:|.:..|||..|..
  Fly   178 NKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPN 242

  Fly   221 LMHLSLQGNAWNCSC--ELQDFRDFAISKRLYTPPTD----------------------CQEPPQ 261
            |.:|.|..|..:.|.  .||...|.......|.|...                      ||.|..
  Fly   243 LQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAA 307

  Fly   262 LRGKLWSEVPSENFA----CRPRILGSVRSFIEANHDNI---------------------SLPCR 301
            |...:.:...|:|:.    |.......:..:::.:|..|                     :|..|
  Fly   308 LAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLLMR 372

  Fly   302 IVGSPRPNVTWVY-NKRPLQQYDPRVRV-LTSVEQM-----------PEQPSQVLTSELRIVGVR 353
            :..|..|::..:: ....:.:..|:..| |.:::.:           |....::||..|...||.
  Fly   373 VPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPLSLPKLLTLNLESSGVE 437

  Fly   354 ASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIIT 418
            :..:.....:...|        .||:..:   .:..||.:|:....:|
  Fly   438 SVSQSIVHTLPQLR--------DLLLEDN---PIKCSDLLGIAEWASP----------------- 474

  Fly   419 TLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEV 483
                            ||.:...|.:...:||...:.::..:.||  ..|.   ...::..:.:.
  Fly   475 ----------------CRSVDAGQSNGASVSGRVDLKTEYLQFHN--FYEN---FSSRECGIRKP 518

  Fly   484 NPVEKPPR----------RTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDE----EAVSVAMSD 534
            ....|||.          .|...|:...:...|.:.|.....|..|..:..|    :|.|.|.|.
  Fly   519 ENDTKPPSCSLTRASATLTTTPRSMSKVEKSQEAQATATSVEVAAATAATSEKTGIQATSAAQST 583

  Fly   535 TTTTPRSRHTYVDDAYANSLPPDLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTS---- 595
            ...|...|     :|.|.:...|..|.|...  .:.::||: .|||.|:......|...||
  Fly   584 AAATTAER-----EAIATATSSDTTATPTLA--AAAAIQSA-GNIPAQLTTKTLRPTETTSLAQL 640

  Fly   596 ---------PVYTHMTP----HGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQ 647
                     |..|..||    ..:..||..||               |.::||.:::
  Fly   641 QRRQQMPGMPAKTTETPAKNLPSLAQTKATTA---------------LPILATRDAA-------- 682

  Fly   648 LQQQQQHHHHHQQQQQQQQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRAPSWAPS 712
                                    .|||......|...|.||..|                 |.|
  Fly   683 ------------------------TATTEINSDKPTNISGATKTV-----------------ATS 706

  Fly   713 TSGAAGHGSIQLSEFQSPTSPNPSETGTATTAE--LQAEPVYDNLG-LRTTAGGNSTLNLTKIAG 774
            .:..|...:|::.  |:..:...|:...|..|.  |...|..|..| :.||...::||
  Fly   707 AAEIATPPAIEVP--QTILAGKKSDKMPADKAHETLLKYPTRDTSGQVATTPHKHATL------- 762

  Fly   775 SQGGAGQQYSMRDRPLPATP--------------SLTSVSSATNA---SKIYEPIHELIQQQQQL 822
                   |..::||.|..||              .|....:||.|   |::.:|    .||.|..
  Fly   763 -------QLHVKDRHLIGTPLLMHKGDVLLVDAEQLLLPGTATVADADSEVLDP----SQQHQSA 816

  Fly   823 QQQQQQ------QQQRLGSMDTEPLYGVRQQGITILPGSSISGA--GLGHAA-YLSPGSGAAVSP 878
            :|::.|      |...:......|..|.:::     |..||...  ...||| .:...:..:.:|
  Fly   817 EQEKHQSATDKRQADAINGDTKSPAKGHKKK-----PSLSIKKMTYSTKHAAKTVEDMAATSKTP 876

  Fly   879 SHASSSGDSPKAA 891
            .|..||.::||.|
  Fly   877 QHQHSSVNTPKEA 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	12/41 (29%)
		leucine-rich repeat	76..100	CDD:275380
		LRR_8	99..159	CDD:290566	12/40 (30%)
		leucine-rich repeat	101..124	CDD:275380	2/5 (40%)
		LRR	122..145	CDD:197688	6/22 (27%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	148..207	CDD:290566	20/85 (24%)
		leucine-rich repeat	149..172	CDD:275380	11/42 (26%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	11/31 (35%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	13/75 (17%)
		Ig	296..376	CDD:143165	15/113 (13%)
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	50/233 (21%)
		leucine-rich repeat	124..143	CDD:275380	6/21 (29%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..194	CDD:275380	3/21 (14%)
		LRR_8	193..253	CDD:290566	16/59 (27%)
		leucine-rich repeat	195..218	CDD:275380	4/22 (18%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR_8	241..301	CDD:290566	10/59 (17%)
		leucine-rich repeat	243..311	CDD:275380	14/67 (21%)
		leucine-rich repeat	312..335	CDD:275380	3/22 (14%)
		LRR_8	334..415	CDD:290566	9/80 (11%)
		leucine-rich repeat	336..359	CDD:275380	2/22 (9%)
		leucine-rich repeat	360..380	CDD:275380	3/19 (16%)
		LRR_8	379..460	CDD:290566	13/91 (14%)
		LRR_4	379..>415	CDD:289563	4/35 (11%)
		leucine-rich repeat	381..404	CDD:275380	3/22 (14%)
		leucine-rich repeat	405..449	CDD:275380	6/43 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930