DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek5 and CD180

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_005573.2 Gene:CD180 / 4064 HGNCID:6726 Length:661 Species:Homo sapiens


Alignment Length:391 Identity:78/391 - (19%)
Similarity:148/391 - (37%) Gaps:97/391 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 TDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNV 101
            |.|.|.|..     ....|:.:|:|..|::||..:.|..:.|:|:.|.:|.:....|  :.|.|:
Human    22 TSWDQMCIE-----KEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTF--SRLMNL 79

  Fly   102 HKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVII---NNNEIEVLP 163
            ..:.|..|.|..:|.:.|:..|.|..|.|:||.:..:...:..|.:.|:::.:   ..:.:|.:|
Human    80 TFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIP 144

  Fly   164 NHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQG 228
            .|   ||..|..:...:|.:..::.........|..:..:.|.:.::.:|..:.|::.::|||..
Human   145 VH---NLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNF 206

  Fly   229 NAWNC-------------------------------------SCELQDFRDF-------AISKRL 249
            |..|.                                     |..|..|.|.       |:.|.|
Human   207 NGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGL 271

  Fly   250 YTPPTDCQ---EPPQLRGKLWSEVPSENFACRPRI-------------------LGSVRSFI-EA 291
                  |:   |...|:...:|::.|..|.|..::                   |..::..: ..
Human   272 ------CEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSV 330

  Fly   292 NH-DNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRAS 355
            || |.:   |:|..:..|::|.:|.:..:::....|..|       |:...:.|.:|....:.||
Human   331 NHFDQL---CQISAANFPSLTHLYIRGNVKKLHLGVGCL-------EKLGNLQTLDLSHNDIEAS 385

  Fly   356 D 356
            |
Human   386 D 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 20/86 (23%)
leucine-rich repeat 76..100 CDD:275380 6/23 (26%)
LRR_8 99..159 CDD:290566 14/62 (23%)
leucine-rich repeat 101..124 CDD:275380 5/22 (23%)
LRR 122..145 CDD:197688 6/22 (27%)
leucine-rich repeat 125..148 CDD:275380 6/22 (27%)
LRR_8 148..207 CDD:290566 10/61 (16%)
leucine-rich repeat 149..172 CDD:275380 6/25 (24%)
leucine-rich repeat 173..196 CDD:275380 2/22 (9%)
LRR_8 197..>229 CDD:290566 7/31 (23%)
leucine-rich repeat 197..220 CDD:275380 4/22 (18%)
LRRCT 229..277 CDD:214507 15/94 (16%)
Ig 296..376 CDD:143165 13/61 (21%)
CD180NP_005573.2 leucine-rich repeat 38..57 CDD:275380 6/18 (33%)
LRR 1 54..75 5/22 (23%)
leucine-rich repeat 58..78 CDD:275380 6/21 (29%)
LRR 2 78..99 6/20 (30%)
leucine-rich repeat 79..102 CDD:275380 5/22 (23%)
LRR_8 102..161 CDD:290566 14/61 (23%)
LRR 3 102..123 5/20 (25%)
leucine-rich repeat 103..126 CDD:275380 6/22 (27%)
LRR 4 126..147 4/23 (17%)
leucine-rich repeat 127..150 CDD:275380 6/25 (24%)
LRR 5 150..171 2/20 (10%)
leucine-rich repeat 151..174 CDD:275380 2/22 (9%)
LRR 6 174..195 3/20 (15%)
leucine-rich repeat 175..195 CDD:275380 3/19 (16%)
leucine-rich repeat 196..234 CDD:275380 6/37 (16%)
LRR 7 201..221 5/19 (26%)
leucine-rich repeat 235..275 CDD:275380 8/45 (18%)
LRR 8 275..296 5/20 (25%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
LRR 9 299..320 0/20 (0%)
leucine-rich repeat 300..322 CDD:275380 1/21 (5%)
LRR 10 322..343 5/23 (22%)
LRR_8 323..382 CDD:290566 13/68 (19%)
leucine-rich repeat 323..371 CDD:275380 11/57 (19%)
LRR_RI 327..541 CDD:238064 16/70 (23%)
LRR 11 346..366 3/19 (16%)
LRR_8 371..432 CDD:290566 5/16 (31%)
LRR 12 371..391 5/16 (31%)
leucine-rich repeat 372..397 CDD:275380 5/15 (33%)
LRR 13 397..418
leucine-rich repeat 398..421 CDD:275380
LRR_8 420..481 CDD:290566
LRR 14 421..442
leucine-rich repeat 422..446 CDD:275380
LRR 15 446..466
leucine-rich repeat 447..470 CDD:275380
LRR 16 470..493
leucine-rich repeat 471..497 CDD:275380
LRR_8 497..555 CDD:290566
LRR 17 497..518
leucine-rich repeat 498..521 CDD:275380
LRR 18 521..544
leucine-rich repeat 522..543 CDD:275380
LRR 19 546..564
TPKR_C2 577..626 CDD:301599
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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