DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and caps

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	189/927 - (20%)
Similarity:	287/927 - (30%)	Gaps:	336/927 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRRLGMILLLLGVLVVLMALPPPTAGTTDWMQSC-GTCHC-----QWNSGKKSAD---------- 58
            |:...:.|.|  .|.:::|..|...|    :.:| ..|.|     ..|.|:.:.|
  Fly    16 GQAFSLCLCL--CLCLVLATLPVALG----LANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAI 74

  Fly    59 ----CKNKALTKIPQDMS------------NEM--------------QVLDFAHNQIPELRREEF 93
                .||..|..|...|.            |:|              |.|...||:|.::..:.|
  Fly    75 QRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTF 139

  Fly    94 LLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNE 158
            |  ||..:..:.||...|.|:....|..:..|.||:|..|||..:.|....||:.||.:.:::|.
  Fly   140 L--GLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNT 202

  Fly   159 IEVLPNHL-------------------------FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALS 198
            :..:|..|                         |.:|..|:|::.|...|..:......|.::|.
  Fly   203 LTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR 267

  Fly   199 AISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCE-----LQDFRDFAI--SKRL------- 249
            .:.|..|||..:....|:.|.:|..|::..|.:.....     |::.|...:  ::||
  Fly   268 FLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGA 332

  Fly   250 YTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVY 314
            ::..|:.:.......|..:|:.|......|.:...|   ::||        ::.......|.|.
  Fly   333 FSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVV---LKAN--------QLSSLDEGLVPWA- 385

  Fly   315 NKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLV 379
               .||..|           :.|.|.:   .:.|::.:|      :..|:.|            .
  Fly   386 ---DLQTLD-----------LSENPFE---CDCRLLWLR------HLLVSRN------------A 415

  Fly   380 SGDYAGAVSASD----------------GMGMGAIGAPTIDPQTNMFLIIC-LIITTLLLLLLVA 427
            ||.||..:.|..                |...||.....|   ..:.::.| .:||||.|:|
  Fly   416 SGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAI---IGILVVACAALITTLALVL--- 474

  Fly   428 VLTLFWYCR-RIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKPPR 491
                 :.|| ||:      .|:.|...:..|.              .|.||:..:|......||.
  Fly   475 -----YTCRHRIR------EMLKGHSALGRKE--------------REYQKTFSDEEYMSRPPPG 514

  Fly   492 RTDIESVDGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPP 556
            ...:....||             ..|:|.:||                             .:|.
  Fly   515 GGGVHPAAGG-------------YPYIAGNSR-----------------------------MIPV 537

  Fly   557 DLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAPHNGFMT 621
            ..|...|  ||                      ||.|          .|..|....:........
  Fly   538 TELXLEA--PP----------------------PPQL----------RGRGGGGGASTASGAVQQ 568

  Fly   622 LQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHHHQQQQQQQQQ--------QQ--------- 669
            ||.|.    |:...:||..|..|.|.:.      ::.||||.||||        ||
  Fly   569 LQVPS----AVDQASNSFAQLSHIHYMT------NNGQQQQAQQQQSTSKMHHSQQDMRLLACNG 623

  Fly   670 -HPL-ATTSPFLPAPVV-------YSP--ATGVVM-------------KQGYMTIPRKPRAPSWA 710
             .|| ||:.|....|||       ||.  |.|:.:             .|.|..:..||......
  Fly   624 GKPLNATSLPRHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQNQSHNQHYGGVYAKPCDAMSE 688

  Fly   711 PSTSGAAGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGN----------- 764
            |.......|.|:.| :...|.||.|       |....|.|:.:.:|:....|..
  Fly   689 PGYIHNNSHYSLPL-DHDLPPSPTP-------TPPPPALPLRNGVGMALIHGNTTGRRSFNNNNN 745

  Fly   765 -STLNLTKIAGSQGGAG 780
             |||:.....|..||.|
  Fly   746 VSTLSNNNHHGIGGGVG 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	27/83 (33%)
		leucine-rich repeat	76..100	CDD:275380	9/23 (39%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	15/83 (18%)
		leucine-rich repeat	149..172	CDD:275380	7/47 (15%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	9/31 (29%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	9/61 (15%)
		Ig	296..376	CDD:143165	11/79 (14%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/20 (25%)
		LRR_8	96..155	CDD:290566	13/60 (22%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	9/24 (38%)
		LRR_8	143..201	CDD:290566	17/57 (30%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	55/275 (20%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	5/23 (22%)
		LRR_8	217..276	CDD:290566	10/58 (17%)
		leucine-rich repeat	218..241	CDD:275380	2/22 (9%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		LRR_8	265..321	CDD:290566	12/55 (22%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		LRR_8	312..374	CDD:290566	11/72 (15%)
		leucine-rich repeat	314..335	CDD:275380	3/20 (15%)
		leucine-rich repeat	339..363	CDD:275380	3/23 (13%)
		LRRCT	395..445	CDD:214507	10/70 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840