DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and trn

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	156/824 - (18%)
Similarity:	264/824 - (32%)	Gaps:	272/824 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLVVLMAL-PPPTAGTTDWMQSCGT-CHCQWNS-----GKKSADCKNKALTKIPQDM- 71
            |::..:|:..:|.:: ..|.||    :.:|.. |.|..|:     |:...|....||....|.:
  Fly     5 MMIAFVGIWCILASIGVEPAAG----LANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLV 65

  Fly    72 --SNEMQVLD--------------------------FA-----------HNQIPELRREEFLLAG 97
              ||:::.:|                          ||           ||:|.::..:.|:  |
  Fly    66 IKSNKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFI--G 128

  Fly    98 LPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVL 162
            |..|..:.||...|.|:|:..|..|..:.||:|..|||..|.|..|.||.:||.:.:::|.:..:
  Fly   129 LSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTV 193

  Fly   163 PNHL-------------------------FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISL 202
            |:.:                         |.:|..|:|:|.:...||.:....|.|...|..:.|
  Fly   194 PDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDL 258

  Fly   203 EQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCE-----LQDFRDFAIS-----KRLYTPP---- 253
            ..|||..:.......|.:|..|||..|.:....|     |:..:...::     ||:.|..
  Fly   259 SDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDN 323

  Fly   254 --------------TDCQEPPQLRGKLWSEVPSENFACRPRILGSVR---------SFIEANHDN 295
                          .:.||     |.|......::...:...|.|:.         ..::.:.:.
  Fly   324 GNLEYLNLSSNKMLLEVQE-----GALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENP 383

  Fly   296 ISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVL---TSELRIVGVRASDK 357
            :|..||::        |::|            :|.:.....:..|::|   ...||...:|..:.
  Fly   384 LSCDCRVM--------WLHN------------LLVAKNASQDDVSELLCEFPERLRGESLRHLNP 428

  Fly   358 GAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLL 422
            ....|.      .|:...|.|:.....|:.:.                           ||.|.|
  Fly   429 AMMGCT------HADPRKQALIGALLVGSAAT---------------------------ITALAL 460

  Fly   423 LLLVAVLTLFWYC-------------------RRIKTYQK---DTTMMS---------GDGLISS 456
            :|        :.|                   |:.:.|||   |...||         |   |.|
  Fly   461 VL--------YRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLG---IHS 514

  Fly   457 KMDKTHNGSMLEGSV----IMEMQKSLLNEVNPVEK-----PPRRTDIESV-------------- 498
            ....|:......|:.    :..|..:.|..::|.:|     .|..|.|...
  Fly   515 TFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMISEKKLNNNKALVSQGAI 579

  Fly   499 -DGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSRHTYVDDAYANSLPPDLLAFP 562
             |....||.:|...:...|:..|...:.......:|.|.|...|.::|.|....:..|..
  Fly   580 DDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATATVGDSCYSYADVPMVHGAPLG----- 639

  Fly   563 ARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYG--------TKTMTAPHNGF 619
               .|..|.::.:|.:...:.:|.......:....|.:...|  |.        :||.|.|
  Fly   640 ---GPNQPQLRLTQEHFKQRELYDQEMGSEILDHNYIYSNTH--YSMPLEQLGRSKTPTPP---- 695

  Fly   620 MTLQHPKSRNLAL---IATTNSSRQHQHHHQLQQQQQHHHHHQQ 660
                 |....|.|   :..|...|..|.....|:|||:::..:|
  Fly   696 -----PMPPALPLRNGLCATTGRRSFQQKSASQKQQQNNNTLRQ 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	31/120 (26%)
		leucine-rich repeat	76..100	CDD:275380	9/60 (15%)
		LRR_8	99..159	CDD:290566	22/59 (37%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR	122..145	CDD:197688	10/22 (45%)
		leucine-rich repeat	125..148	CDD:275380	11/22 (50%)
		LRR_8	148..207	CDD:290566	16/83 (19%)
		leucine-rich repeat	149..172	CDD:275380	6/47 (13%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	10/75 (13%)
		Ig	296..376	CDD:143165	13/82 (16%)
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/17 (24%)
		LRR_8	83..142	CDD:290566	11/60 (18%)
		leucine-rich repeat	84..107	CDD:275380	2/22 (9%)
		leucine-rich repeat	108..131	CDD:275380	6/24 (25%)
		LRR_RI	129..421	CDD:238064	65/316 (21%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	11/22 (50%)
		leucine-rich repeat	180..204	CDD:275380	4/23 (17%)
		LRR_8	203..263	CDD:290566	12/59 (20%)
		leucine-rich repeat	205..228	CDD:275380	2/22 (9%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	13/55 (24%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	6/63 (10%)
		leucine-rich repeat	326..350	CDD:275380	4/28 (14%)
		leucine-rich repeat	351..373	CDD:275380	2/21 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840