DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and CG32055

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	74/382 - (19%)
Similarity:	122/382 - (31%)	Gaps:	155/382 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QWNSGKKSADCKNKALTKIPQ-----------DMS-----NEMQVLDFAHNQIPELRREEFLLAG 97
            ||        |..:.|.|:.:           ||.     ..::||:.::|.:.|::|..|:..|
  Fly   207 QW--------CHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPG 263

  Fly    98 ----------LPNVHKIF----------LRNCT-----IQEVHREAFKGLHILIELDLSGNRIRE 137
                      ..|:.|:.          ||...     |..:|..||.||..|..|.|.||:|..
  Fly   264 EIAPLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISI 328

  Fly   138 LHPGTFAGLEKLRNVIINNNEIE----------VLPNHLFVNLS----------------FLSRI 176
            |....||.|..|..:.::.|.|:          :|...::::||                |:..:
  Fly   329 LPDDVFANLTALEKLDLSKNNIQKLGLRVFGERILRKLIYLDLSNNYIADLHPLALSSMPFIKEL 393

  Fly   177 EFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHL----------------- 224
            ..|.|||..:.|.:||....|..:::.:|||..:..|....|.:|.||
  Fly   394 RLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQ 458

  Fly   225 --------SLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRI 281
                    :|:||.|.|.|
  Fly   459 NLLQLRNITLEGNPWQCLC---------------------------------------------- 477

  Fly   282 LGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQ 338
            |..:.|::...|         |...||:..:...::||....|..:.|..:::...|
  Fly   478 LDEITSWLNGRH---------VSYARPSSAYFSGRKPLCVVTPMDKCLRDLQETKAQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	29/108 (27%)
		leucine-rich repeat	76..100	CDD:275380	7/33 (21%)
		LRR_8	99..159	CDD:290566	22/74 (30%)
		leucine-rich repeat	101..124	CDD:275380	9/37 (24%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	16/84 (19%)
		leucine-rich repeat	149..172	CDD:275380	6/48 (13%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	197..>229	CDD:290566	10/56 (18%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	4/47 (9%)
		Ig	296..376	CDD:143165	8/43 (19%)
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380
		LRR_8	128..180	CDD:290566
		leucine-rich repeat	128..147	CDD:275380
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..192	CDD:275380
		LRR_RI	<187..400	CDD:238064	43/200 (22%)
		LRR_8	192..251	CDD:290566	10/51 (20%)
		leucine-rich repeat	193..216	CDD:275380	4/16 (25%)
		leucine-rich repeat	217..240	CDD:275380	2/22 (9%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	2/22 (9%)
		LRR_8	290..350	CDD:290566	20/59 (34%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		leucine-rich repeat	316..339	CDD:275380	10/22 (45%)
		LRR_8	340..400	CDD:290566	9/59 (15%)
		leucine-rich repeat	340..365	CDD:275380	4/24 (17%)
		leucine-rich repeat	366..389	CDD:275380	2/22 (9%)
		leucine-rich repeat	390..413	CDD:275380	7/22 (32%)
		LRR_8	391..448	CDD:290566	16/56 (29%)
		leucine-rich repeat	414..437	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930