DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrrc24

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_932787.1	Gene:	Lrrc24 / 378937	MGIID:	3605040	Length:	521	Species:	Mus musculus

Alignment Length:	540	Identity:	137/540 - (25%)
Similarity:	211/540 - (39%)	Gaps:	115/540 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MILLLLGVLV--VLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQ 76
            ::|||||:|:  :|..|||...|       | ..|.|.    ..:.:|....|..:|..:....|
Mouse     8 LLLLLLGLLLLPLLPGLPPRATG-------CPAACRCY----SATVECGALRLRVVPPGIPPGTQ 61

  Fly    77 VLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPG 141
            .|....|.|..|  |:..||.|..:..::|.|.|::.:...||:....|:||.|:|||:|.|..|
Mouse    62 TLFLQDNSIAHL--EQGSLAPLAALRHLYLHNNTLRALESGAFRAQPRLLELALTGNRLRGLRGG 124

  Fly   142 TFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNR 206
            .|.||.:||.:.:..|::..|.:..|::|..|..:..:.|.:..::....||..:|:.:.|.:|:
Mouse   125 AFVGLVQLRVLYLAGNQLAKLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQ 189

  Fly   207 LSHLHKETFKDLQKLMHLSLQGNAWNCSCELQ--------------DFRDFAISKRLYTPPTDCQ 257
            |..:.||..:.|..|..|.|..|.|.|.|.|.              ..||..|:         |.
Mouse   190 LGTISKEALQPLSSLQVLRLTENPWRCDCALHWLGSWIKEGGRRLLSSRDKKIT---------CA 245

  Fly   258 EPPQLRGKLWSEVPSENFACRPRILGSVRSFIEAN-HDNISLPCRIVGSPRPNVTWVYNKRPLQQ 321
            |||:|..:...||...:..|.|..:........|| .:::.:.|:..|.|:|.|.|  .|.|
Mouse   246 EPPRLALQSLLEVSGGSLICIPPSVNVEPPEFTANLGEDLQVACQASGYPQPLVVW--RKVP--- 305

  Fly   322 YDPRVRVLTSVEQMPEQPSQVL---------------TSELRIVGVRASDKGAYTCVADNRGGRA 371
             .||       :..|:..:|:.               :..|.:..:..:..|.|.|.|.|.||:|
Mouse   306 -QPR-------DGKPQAQAQLEGGAPGLGGHGTRDTGSGMLFLTNITLAHAGKYECEAANAGGKA 362

  Fly   372 EAEFQLLVSGDYAGAVSASD------------------GMGMGAIGAPTIDPQTNMFLIICLIIT 418
            ...|.|||:.....:....|                  .|...|:|..|   ||       .|..
Mouse   363 RVPFHLLVNASRQQSQQLPDPQAPATRPVGHEPQHEAGSMAFRALGLAT---QT-------AITA 417

  Fly   419 TLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLI--------------SSKMDKTHNGSMLEG 469
            .:.||.|.|:|.....||| :..:|.....||:|.:              ..::...|...|.
Mouse   418 AIALLALTALLLAAMICRR-RRRRKKVPAPSGEGTLFVNDYSDGPCTFAQLEELRDDHGHEMF-- 479

  Fly   470 SVIMEMQKSLLNEVNPVEKP 489
              :::..|.|..||.|.|.|
Mouse   480 --VIDRSKPLFPEVLPEEAP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	30/83 (36%)
		leucine-rich repeat	76..100	CDD:275380	9/23 (39%)
		LRR_8	99..159	CDD:290566	21/59 (36%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	11/22 (50%)
		leucine-rich repeat	125..148	CDD:275380	13/22 (59%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	4/22 (18%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	15/61 (25%)
		Ig	296..376	CDD:143165	21/94 (22%)
Lrrc24	NP_932787.1	LRR_8	48..92	CDD:290566	12/45 (27%)
		LRR 1	59..80		7/22 (32%)
		LRR_RI	<60..>166	CDD:238064	35/107 (33%)
		leucine-rich repeat	61..83	CDD:275380	9/23 (39%)
		LRR 2	83..104		5/20 (25%)
		LRR_8	84..142	CDD:290566	21/57 (37%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		LRR 3	107..128		11/20 (55%)
		leucine-rich repeat	108..131	CDD:275380	13/22 (59%)
		LRR_8	131..213	CDD:290566	20/81 (25%)
		LRR_4	131..171	CDD:289563	8/39 (21%)
		LRR 4	131..152		5/20 (25%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR 5	155..176		2/20 (10%)
		leucine-rich repeat	156..179	CDD:275380	4/22 (18%)
		LRR 6	179..200		6/20 (30%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		LRRCT	212..265	CDD:214507	15/61 (25%)
		Ig	267..361	CDD:299845	22/106 (21%)
		IG_like	274..370	CDD:214653	25/108 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..330		4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..395		1/20 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4579
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.920