DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and Lrt

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	123/593 - (20%)
Similarity:	207/593 - (34%)	Gaps:	181/593 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ALTKIPQDMSNEMQV---LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHI 124
            ||..:|.:..:.:..   ||.|:|:|..|...:|:  ||.::..:.|.|..|..:.:..|..|..
  Fly   234 ALMSVPWNALSTLSALERLDLANNKIKALGTADFV--GLTSLVYLELSNNQISSISQRTFVNLRK 296

  Fly   125 LIELDLSGNRIRE---------------------------LHPGTFAGLEKLRNVIINNNEIEVL 162
            |..|.|.|||:.:                           |...|..|:..|.::.:|.|.|:.:
  Fly   297 LEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQTLPGMRNLESLNLNRNLIKSI 361

  Fly   163 PNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQN--------RLSHLHKETFKDL- 218
            .|....|.|.|..:..|:|::..:|.|.|.|..||.::.|..|        .|.||.:.|..||
  Fly   362 QNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAISSASLQHLSRLTVLDLT 426

  Fly   219 ---------------------------------------QKLMHLSLQGNAWNCSCELQDFRDFA 244
                                                   ::|..|.:|.|..:|.|.::.|.::.
  Fly   427 HNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESLQMQENPLSCDCSIRPFAEWL 491

  Fly   245 ISKRLYTP-PTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRP 308
            ...:|::. ...|..||:|.|....:||.|..:|         .......||.::...:....:|
  Fly   492 QESQLHSSLSASCVTPPRLEGAPLLQVPVETLSC---------DMDNVEKDNANIMQHLETLAKP 547

  Fly   309 NVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVA--------- 364
            |.|     .|::.....: :|..:....:. ..:||..|.:      .|..|.|.|
  Fly   548 NQT-----SPIKDLSEEI-ILHELHFSTDY-GLILTWLLNL------SKKDYMCDAIFVYKEEHI 599

  Fly   365 -----DNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTLLLLL 424
                 ||.....|::   :|:|....:|...|...: .||      ::..|   ||::
  Fly   600 NEILIDNSPIHCESK---VVNGQNTVSVIVPDSSSL-EIG------ESYRF---CLVM------- 644

  Fly   425 LVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIMEMQKSLLNEVNPVEKP 489
                         |:..:.|:.:..|...| ::::::..|::   .|..:.|:......|.: ||
  Fly   645 -------------IQEQKPDSELNIGCSNI-TRLERSSPGAV---PVSRQYQRRPYYNANEL-KP 691

  Fly   490 PRRTDIESV-DGGDDVLEIKKTLLDDTVYVANHSRDEEAVSVAMSDTTTTPRSR--HTY-VDDAY 550
                  |.| |.|:|             |..|..|..   ||..|....|.:|.  |:| |.|:.
  Fly   692 ------EVVHDAGED-------------YQVNQRRFN---SVVGSQPQQTQQSTLLHSYTVIDSL 734

  Fly   551 ANSLPPDL 558
            ..|..|.|
  Fly   735 NKSFLPGL 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	26/113 (23%)
		leucine-rich repeat	76..100	CDD:275380	9/26 (35%)
		LRR_8	99..159	CDD:290566	17/86 (20%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	9/49 (18%)
		leucine-rich repeat	125..148	CDD:275380	9/49 (18%)
		LRR_8	148..207	CDD:290566	18/66 (27%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	197..>229	CDD:290566	12/79 (15%)
		leucine-rich repeat	197..220	CDD:275380	9/70 (13%)
		LRRCT	229..277	CDD:214507	13/48 (27%)
		Ig	296..376	CDD:143165	15/93 (16%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	23/101 (23%)
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380	3/13 (23%)
		LRR_8	249..307	CDD:290566	19/59 (32%)
		leucine-rich repeat	249..272	CDD:275380	9/24 (38%)
		LRR_RI	<270..479	CDD:238064	43/208 (21%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..322	CDD:275380	6/24 (25%)
		LRR_8	322..382	CDD:290566	13/59 (22%)
		leucine-rich repeat	323..347	CDD:275380	3/23 (13%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		LRR_8	370..428	CDD:290566	18/57 (32%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		LRR_8	418..478	CDD:290566	7/59 (12%)
		leucine-rich repeat	420..443	CDD:275380	3/22 (14%)
		leucine-rich repeat	444..467	CDD:275380	0/22 (0%)
		LRRCT	476..526	CDD:214507	14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910