DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek5 and Lrrc24

DIOPT Version :9

Sequence 1:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster
Sequence 2:NP_001129368.1 Gene:Lrrc24 / 362945 RGDID:1308720 Length:521 Species:Rattus norvegicus


Alignment Length:542 Identity:139/542 - (25%)
Similarity:220/542 - (40%) Gaps:96/542 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 MILLLLGVLV--VLMALPPPTAGTTDWMQSC-GTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQ 76
            ::|||||:|:  :|..|||...|       | ..|.|.    ..:.:|....|..:|..:....|
  Rat     8 LLLLLLGLLLLPLLPGLPPRATG-------CPAACRCY----SATVECGALRLRVVPPGIPPGTQ 61

  Fly    77 VLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPG 141
            .|....|.|..|  |:..||.|..:..::|.|.|::.:...||:....|:||.|:|||:|.|..|
  Rat    62 TLFLQDNSIAHL--EQGALAPLAALRHLYLHNNTLRALESGAFRAQPRLLELALTGNRLRGLRGG 124

  Fly   142 TFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNR 206
            .|.||.:||.:.:..|::..|.:..|::|..|..:..:.|.:..::....||..:|:.:.|.:|:
  Rat   125 AFVGLVQLRVLYLAGNQLAKLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQ 189

  Fly   207 LSHLHKETFKDLQKLMHLSLQGNAWNCSCELQ--------------DFRDFAISKRLYTPPTDCQ 257
            |..:.||..:.|..|..|.|..|.|.|.|.|.              ..||..|:         |.
  Rat   190 LGTISKEALQPLSSLQVLRLTENPWRCDCALHWLGSWIKEGGRRLLSSRDKKIT---------CA 245

  Fly   258 EPPQLRGKLWSEVPSENFACRPRILGSVRSFIEAN-HDNISLPCRIVGSPRPNVTWVYNKRPLQQ 321
            |||:|..:...||...:..|.|..:.:....:.|| .:::.:.|:..|.|:|.|.|   ::.||.
  Rat   246 EPPRLALQSLLEVSGGSLICIPPSVNAEPPELTANLGEDLQVACQASGYPQPLVVW---RKMLQP 307

  Fly   322 YDPRVRVLTSVEQMPEQPSQVLTSE-----LRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSG 381
            .|.:.:....:|..........|.:     |.:..:..:..|.|.|.|.|.||:|...|.|||:.
  Rat   308 RDGKPQAQVQLEGGAPGLGGHATRDTGSGMLFLTNITLAHAGKYECEATNAGGKARVLFHLLVNA 372

  Fly   382 DY----------------AGAVSASDG--MGMGAIGAPTIDPQTNMFLIICLIITTLLLLLLVAV 428
            ..                .|.....:|  |...|:|..|   ||       .|...:.||.|.|:
  Rat   373 SRQQSQQLPAPQAPATRPVGQEPQHEGGSMAFRALGLAT---QT-------AITAAIALLALTAL 427

  Fly   429 LTLFWYCRRIKTYQKDTTMMSGDGLI--------------SSKMDKTHNGSMLEGSVIMEMQKSL 479
            |.....||| :..:|...:.||:|.:              ..::...|...|.    :::..|.|
  Rat   428 LLAAMICRR-RRRRKKMPVPSGEGTLFVNDYSDGPCTFAQLEELRDDHGHEMF----VIDRSKPL 487

  Fly   480 LNEVNPVEKPPRRTDIESVDGG 501
            ..|: |.|:||.....|.:..|
  Rat   488 FTEI-PPEEPPEHNPPEGLRSG 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 30/83 (36%)
leucine-rich repeat 76..100 CDD:275380 9/23 (39%)
LRR_8 99..159 CDD:290566 21/59 (36%)
leucine-rich repeat 101..124 CDD:275380 5/22 (23%)
LRR 122..145 CDD:197688 11/22 (50%)
leucine-rich repeat 125..148 CDD:275380 13/22 (59%)
LRR_8 148..207 CDD:290566 13/58 (22%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
leucine-rich repeat 173..196 CDD:275380 4/22 (18%)
LRR_8 197..>229 CDD:290566 10/31 (32%)
leucine-rich repeat 197..220 CDD:275380 7/22 (32%)
LRRCT 229..277 CDD:214507 15/61 (25%)
Ig 296..376 CDD:143165 20/84 (24%)
Lrrc24NP_001129368.1 leucine-rich repeat 61..83 CDD:275380 9/23 (39%)
PPP1R42 63..>212 CDD:411060 46/150 (31%)
LRR_8 84..142 CDD:404697 21/57 (37%)
leucine-rich repeat 84..107 CDD:275380 5/22 (23%)
leucine-rich repeat 108..131 CDD:275380 13/22 (59%)
leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
leucine-rich repeat 156..179 CDD:275380 4/22 (18%)
leucine-rich repeat 180..203 CDD:275380 7/22 (32%)
PCC 188..>259 CDD:188093 22/79 (28%)
Ig_3 267..357 CDD:404760 19/92 (21%)
Ig strand A 267..271 CDD:409353 1/3 (33%)
Ig strand A' 276..280 CDD:409353 0/3 (0%)
Ig strand B 283..292 CDD:409353 1/8 (13%)
Ig strand C 298..304 CDD:409353 2/8 (25%)
Ig strand D 330..333 CDD:409353 1/2 (50%)
Ig strand E 336..342 CDD:409353 1/5 (20%)
Ig strand F 349..357 CDD:409353 4/7 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 141 1.000 Inparanoid score I4399
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45224
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.920

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