DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek5 and rdo

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	677	Identity:	137/677 - (20%)
Similarity:	244/677 - (36%)	Gaps:	166/677 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 MSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRI 135
            |.:.::.||.:.|.:.:|:.:.|  ..:|.:..:..|||.:::::.:.:..|.:|.||||..|..
  Fly   176 MLSRLKYLDLSGNPLQDLQPDVF--RDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEF 238

  Fly   136 RELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAI 200
            :.|....|..:::|..|:::.|::.|:.:.||.....|:.::...|||.:|....|.....|:.:
  Fly   239 KFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFL 303

  Fly   201 SLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRD------------FAISKRLYTPP 253
            .|..|:|..|..::.:.|..|:.|::.||.      |.|.|:            |....:|:
  Fly   304 DLSYNKLVRLEPQSIRSLSNLLTLNISGNV------LMDLREMRETFEPLIYYFFLTCSKLF--- 359

  Fly   254 TDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNIS------------LPCR----- 301
              .|..|||     :.:...:....|  :|.:..|.:..:.|||            .|||
  Fly   360 --FQLIPQL-----THLAIADMGTMP--VGLLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFL 415

  Fly   302 ------IVGSPRPNVTWVYNKRPLQ-QYDPRV-------RVLTSVEQM----PEQPSQVLTSELR 348
                  :.|.....|..:...|.:: ..:|.:       :::..|.|:    ...|...|...||
  Fly   416 DLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQWKWDTYPICFLPKSLR 480

  Fly   349 IVGVRASD-KGAYTC---VADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNM 409
            ...:...| .|.:||   :.|.....|...:..|..|          |:...||....|
  Fly   481 GAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHG----------GLNTLAILGGII------ 529

  Fly   410 FLIICLIITTLLLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTHNGSMLEGSVIME 474
            |::|.:||     |.|||..:.    .|.:.|.::..:               |||
  Fly   530 FVLIAVII-----LSLVACFSK----NRARYYTREDHL---------------NGS--------- 561

  Fly   475 MQKSLLNEVNPVEKPPRRTDIESVDGGDDVLEIKKTLLDDTVYVANHSR-DEEAVSVAMSDTTTT 538
                   |...:||....|.|.::..|..........|..:....|..: :.:.:|::.::.:|.
  Fly   562 -------ESKCLEKNLEATTITTLGNGSSPTTTTTLTLATSPAAPNGPKTNGQGLSLSPANGSTP 619

  Fly   539 PRSRHTYVDDAYAN---SLPPD--------LLAFPARVPPTSPSMQSSQSNIPDQVIYGI-RSPP 591
            .   |...||....   :.|.|        |:..|   ||  |..|....|: ..::|.: .||.
  Fly   620 V---HGISDDKGKEINFTFPVDDRVCTIDELMPSP---PP--PPQQHPHPNM-GSLMYSVSHSPN 675

  Fly   592 SLTSPVYTHMTPHGIYGTKTMTAP----HNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQ 652
            |.|       |...:....|:..|    |:...|.....:..:.::.........|||||:....
  Fly   676 SAT-------TLAAVAAAATVIPPGAPSHSSMPTPTPTPAEAVVVVLPPPPLPPQQHHHQMDGSL 733

  Fly   653 QHHHHHQQQQQQQQQQQHPLATTSPFL 679
                  ...::.|||..|..:|..|.:
  Fly   734 ------ASLREVQQQLVHLSSTLEPLV 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	21/83 (25%)
		leucine-rich repeat	76..100	CDD:275380	5/23 (22%)
		LRR_8	99..159	CDD:290566	16/59 (27%)
		leucine-rich repeat	101..124	CDD:275380	4/22 (18%)
		LRR	122..145	CDD:197688	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	15/58 (26%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	8/31 (26%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	10/59 (17%)
		Ig	296..376	CDD:143165	21/118 (18%)
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		LRR_8	131..190	CDD:290566	4/13 (31%)
		leucine-rich repeat	132..155	CDD:275380
		LRR_RI	151..422	CDD:238064	59/265 (22%)
		leucine-rich repeat	156..179	CDD:275380	1/2 (50%)
		LRR_8	178..262	CDD:290566	21/85 (25%)
		leucine-rich repeat	180..203	CDD:275380	5/24 (21%)
		leucine-rich repeat	204..251	CDD:275380	12/46 (26%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	16/65 (25%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR_4	298..342	CDD:289563	13/49 (27%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930