DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek5 and IGFALS

DIOPT Version :9

Sequence 1:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster
Sequence 2:	NP_001139478.1	Gene:	IGFALS / 3483	HGNCID:	5468	Length:	643	Species:	Homo sapiens

Alignment Length:	341	Identity:	80/341 - (23%)
Similarity:	133/341 - (39%)	Gaps:	83/341 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLGVLVV------LMALPPPTAGTTDWMQSCGTCHCQWNSGKKSADCKNKALTKIPQDMSNEMQV 77
            |||:.|:      :.:|.|.|.....:::.....|   |..::.|:...:.|        .:::|
Human   327 LLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH---NRIRQLAERSFEGL--------GQLEV 380

  Fly    78 LDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGT 142
            |...|||:.|::...||  ||.||..:.|....::.:..:.|:||..|..|.|.|:.:..:.|.|
Human   381 LTLDHNQLQEVKAGAFL--GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 443

  Fly   143 FAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRL 207
            |.||..||.:.:.:|.:..:.......|:.|..::..:|:|..:...:|.|...|..:.|.:|||
Human   444 FTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508

  Fly   208 SHLHKETFKDLQ------------------------KLMHLS--------------------LQG 228
            :.|..:....||                        :|.:||                    |:|
Human   509 AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEG 573

  Fly   229 NAWNCSCELQDFRDFAISKRLYTP--------PTDCQEPPQLRGKLWSEVPSENFACRPRILG-S 284
            |.|:|.|.|:..||||:......|        ..|||.|......:....|       |.::| .
Human   574 NPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP-------PEVVGLD 631

  Fly   285 VRSFIEANHDNISLPC 300
            :|...||:.    .||
Human   632 LRDLSEAHF----APC 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	28/83 (34%)
		leucine-rich repeat	76..100	CDD:275380	10/23 (43%)
		LRR_8	99..159	CDD:290566	18/59 (31%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	12/75 (16%)
		leucine-rich repeat	197..220	CDD:275380	8/46 (17%)
		LRRCT	229..277	CDD:214507	15/55 (27%)
		Ig	296..376	CDD:143165	2/5 (40%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470
		leucine-rich repeat	95..113	CDD:275380
		leucine-rich repeat	114..137	CDD:275380
		leucine-rich repeat	138..161	CDD:275380
		LRR_8	141..196	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		LRR_8	184..244	CDD:290566
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		leucine-rich repeat	234..257	CDD:275380
		LRR_8	257..316	CDD:290566
		leucine-rich repeat	258..281	CDD:275380
		leucine-rich repeat	282..305	CDD:275380
		leucine-rich repeat	306..324	CDD:275380
		LRR_8	336..388	CDD:290566	11/62 (18%)
		leucine-rich repeat	354..377	CDD:275380	4/33 (12%)
		LRR_8	377..433	CDD:290566	19/57 (33%)
		leucine-rich repeat	378..401	CDD:275380	10/24 (42%)
		leucine-rich repeat	402..423	CDD:275380	3/20 (15%)
		LRR_8	425..484	CDD:290566	15/58 (26%)
		leucine-rich repeat	426..447	CDD:275380	7/20 (35%)
		leucine-rich repeat	450..473	CDD:275380	4/22 (18%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		LRR_8	476..532	CDD:290566	12/55 (22%)
		leucine-rich repeat	498..519	CDD:275380	6/20 (30%)
		leucine-rich repeat	522..543	CDD:275380	0/20 (0%)
		LRR_8	524..575	CDD:290566	5/50 (10%)
		leucine-rich repeat	546..565	CDD:275380	3/18 (17%)
		TPKR_C2	574..618	CDD:301599	14/43 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12231
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910